April, 2024

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Will Biopharma Companies Shun Vaccine R&D In A New Pandemic?

Forbes: Drug Truths

Only biopharma could have combated Covid-19; no other industry has the capacity to do so. When the world was in crisis, this industry responded. If need be, it will again, despite the financial consequences.

Vaccine 214
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Parkinson's Disease: New theory on the disease's origins and spread

Science Daily: Pharmacology News

New hypothesis paper builds on a growing scientific consensus that Parkinson's disease route to the brain starts in either the nose or the gut and proposes that environmental toxicants are the likely source.

Disease 145
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Scientists link certain gut bacteria to lower heart disease risk

Broad Institute

Scientists link certain gut bacteria to lower heart disease risk By Allessandra DiCorato April 2, 2024 Breadcrumb Home Scientists link certain gut bacteria to lower heart disease risk Study finds several species of cholesterol-metabolizing bacteria in people with lower cholesterol levels. By Allessandra DiCorato April 2, 2024 Credit: Ahmed Mohamed Rod-shaped Oscillibacter sp. bacteria take up fluorescently labeled cholesterol (here shown in green).

Disease 145
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Vancomycin May Be Losing Strength Against Common Deadly Infection

Drugs.com

FRIDAY, April 26, 2024 -- Clostridioides difficile (C. difficile) is a leading cause of illness and death, especially for frail and hospitalized Americans. Now, a new study suggests that the leading antibiotic used to fight it, vancomycin, may be.

Hospitals 137
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Psychiatry drugs finally have pharma’s attention. Can they keep it?

BioPharma Drive: Drug Pricing

Recent biotech company acquisitions have put emerging schizophrenia treatments in focus. But many development hurdles still stand in the way of new medicines for the brain.

Treatment 136
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Discovering an Antimalarial Drug in Mao’s China

Codon

Wendi Yan writes about the discovery of artemisinin, a medicine that has saved millions of lives, for Issue 01. Drawing on recently published Chinese texts, Wendi’s reporting provides a more comprehensive telling of this discovery than has previously been described. When her father gave Tu the name “Youyou,” he started with characters from the Chinese classic Book of Odes: “The deer bleat: ‘yōu yōu’ while eating wild ‘hāo’” (&#

Drugs 129

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One third of China's urban population at risk of city sinking, new satellite data shows

Science Daily: Pharmacology News

Land subsidence is overlooked as a hazard in cities, according to new research. Scientists used satellite data that accurately and consistently maps land movement across China.

Research 142
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A new viral surveillance system in West Africa is showing the world how to prevent the next pandemic

Broad Institute

A new viral surveillance system in West Africa is showing the world how to prevent the next pandemic By Allessandra DiCorato April 25, 2024 Breadcrumb Home A new viral surveillance system in West Africa is showing the world how to prevent the next pandemic Scientists from the US and West Africa have teamed up to build a better public health network that can quickly detect and respond to emerging viral threats.

Virus 132
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Antipsychotics May Do Great Harm to People With Dementia: Report

Drugs.com

THURSDAY, April 18, 2024 -- Antipsychotics can substantially increase dementia patients’ risk of many serious health problems, a new study warns.

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Cerevel, in ‘major surprise,’ finds success in late-stage Parkinson’s study

BioPharma Drive: Drug Pricing

Analysts had low expectations for Cerevel’s drug tavapadon, which was something of an afterthought in AbbVie’s proposed buyout of the biotech.

Drugs 126
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Using Internal Traffic Control Plans to Prevent Construction Worker Injuries and Fatalities in Work Zones

NIOSH Science Blog: Drugs

Struck-by injuries are the leading cause of nonfatal injuries and second most common cause of fatalities among construction workers. From 2011 to 2022, there were 1,462 fatal occupational injuries that occurred at road construction sites.[1] Of these, 68% (n=1,000) were among workers in the construction industry (See figure) followed by workers in transportation and warehousing (11%; n=168) and professional and business services (9%; n=132) industries.

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What is health literacy? Definition and resources

Antidote

Equitable access to medical care is valuable for everyone, and an important part of this equation is health literacy. Health literacy encompasses not just access to medical care, but also the ability to understand and use medical guidance. This can include anything from a doctor’s suggestions, to medication dosage information, and aftercare guidance.

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Cells may possess hidden communication system

Science Daily: Pharmacology News

Cells constantly navigate a dynamic environment, facing ever-changing conditions and challenges. But how do cells swiftly adapt to these environmental fluctuations? A new study is answering that question by challenging our understanding of how cells function. A team of researchers suggests that cells possess a previously unknown information processing system that allows them to make rapid decisions independent of their genes.

Research 142
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5 Obtrusive Blockers to Avoid as a Servant Leader

Perficient: Drug Development

We’ve all heard of servant leadership. The concept of “being a servant” to your teams and treating employees as critical individuals to be cultivated and empowered, has strong merit. However, many organizations fall short, with those at the top of the hierarchy viewing employees as interchangeable cogs in the corporate machine. Instead of diving deep into the theories, practices, and benefits of servant leadership, I will focus on a specific, related principle or mind-set: being unobtrusive.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Science Reveals How Aspirin Prevents Colon Cancer

Drugs.com

WEDNESDAY, April 24, 2024 -- Long-term daily use of aspirin has been known to prevent colon cancer, but up to now it’s been unclear why that is.Now, researchers think they understand how aspirin acts against colon cancer, a new study says.Aspirin.

Science 124
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Metsera, a well-funded obesity drug startup, sees chance to challenge Lilly, Novo

BioPharma Drive: Drug Pricing

It’s “early innings” in the obesity drug race, said Metsera CEO Clive Meanwell, whose company has acquired a portfolio of medicines it aims to test in combination.

Drugs 126
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Innovative Strategies in Drug Repurposing

Drug Patent Watch

Drug repurposing, or identifying new therapeutic uses for existing drugs, is gaining significant momentum as a promising approach to accelerate drug development and reduce costs.

Drugs 111
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Workers’ Memorial Day 2024: Statement by NIOSH Director

NIOSH Science Blog: Drugs

Each year, on April 28, we pause to recognize Workers’ Memorial Day and honor those whose death or suffering resulted from exposure to hazards at work. Words are not enough when it comes to change. Research has shown that the health and safety of workers relies on active and intentional involvement in ways that take into consideration workplace hazards, work arrangements and environment, employer-worker relationships, the workers themselves, and their families.

Research 111
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Paleontologists unearth what may be the largest known marine reptile

Science Daily: Pharmacology News

The fossilized remains of a second gigantic jawbone measuring more than two meters long has been found on a beach in Somerset, UK.

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#ScienceSaturday: April 13, 2024

KIF1A

#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. KIF1A-Related Research Clinical exome sequencing uncovers genetic disorders in neonates with suspected hypoxic–ischemic encephalopathy: A retrospective analysis Brain injuries and developmental disorders can be difficu

Disease 111
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Few Young Adults Could Administer Naloxone to Reverse Fentanyl Overdose

Drugs.com

MONDAY, April 22, 2024 -- Even though fentanyl-linked fatal overdoses are soaring among young adults, a new survey of American college students found that just 1 in 7 knew how to administer the overdose antidote drug naloxone.Many who took the.

Drugs 122
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New postpartum depression drugs are here. Diagnosis, treatment hurdles still stand in the way.

BioPharma Drive: Drug Pricing

The first medicine approved for PPD, Sage’s Zulresso, never gained traction. The company is in the midst of launching its second, but long-standing challenges could slow uptake.

Treatment 126
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AI-Driven Drug Discovery: Transforming the Landscape of Pharmaceutical Research

Drug Patent Watch

The pharmaceutical industry in China is undergoing a significant transformation with the adoption of artificial intelligence (AI) technology.

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Deconstructing the Diligence Process: An Approach to Vetting New Product Theses

LifeSciVC

By Aimee Raleigh, Principal at Atlas Venture, as part of the From The Trenches feature of LifeSciVC Ever wondered what goes into diligencing a new idea, program, company, or platform? While each diligence is unique and every investor will have their own approach, below are some considerations that may be more “typical” in a diligence. I will emphasize the obvious disclaimer before diving in – this framework is merely meant to be exemplary and there are always nuances and exceptions unique to eac

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New research shows 'profound' link between dietary choices and brain health

Science Daily: Pharmacology News

New research has highlighted the profound link between dietary choices and brain health.

Research 141
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Women in Stem with Lidia Pieri

Drug Target Review

Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? In the STEM area, I was born as a physicist, which was – among many other things – the inception of looking at the world from many different points of view to get the big picture without losing the fascination with mystery. This eventually translated into looking at my life from many points of view, without fear of change, which opened many opportunities.

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New Rules Mean 3.6 Million Americans Could Get Wegovy Via Medicare, Costing Billions

Drugs.com

WEDNESDAY, April 24, 2024 -- A budget-busting 3.6 million Medicare recipients could now be eligible for coverage of the weight-loss drug Wegovy, a new KFF analysis says.That’s because the U.S. Food and Drug Administration has approved the use of.

Drugs 119
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Ultragenyx says Angelman therapy is working, but safety questions remain

BioPharma Drive: Drug Pricing

Treatment appeared to result in functional and cognitive gains in people with the neurological disorder. Three participants experienced lower extremity weakness, however.

Therapies 122
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#ScienceSaturday: April 6, 2024

KIF1A

#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. KIF1A-Related Research Genetic Alterations in a Large Population of Italian Patients Affected by Neurodevelopmental Disorders We often talk about genetic disorders in the context of mutations that change a protein̵

DNA 111
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Three Principles for Writing Effective Analytics Documentation

Perficient: Drug Development

Documentation is a crucial part of your analytics implementation. From your Solution Design Reference document to your internal wiki for all resources, making sure that you can write and edit your documentation is key to ensuring a cohesive and thorough understanding of your implementation. With effective documentation, you can: Prevent knowledge gaps among team members and assist in onboarding efforts.

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With hybrid brains, these mice smell like a rat

Science Daily: Pharmacology News

Mice lacking an olfactory system have had their sense of smell restored with neurons from rats, the first time scientists have successfully integrated the sensory apparatus of one species into another.

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ChEMBL 34 is out!

The ChEMBL-og

We are delighted to announce the release of ChEMBL 34, which includes a full update to drug and clinical candidate drug data. This version of the database, prepared on 28/03/2024 contains: 2,431,025 compounds (of which 2,409,270 have mol files) 3,106,257 compound records (non-unique compounds) 20,772,701 activities 1,644,390 assays 15,598 targets 89,892 documents Data can be downloaded from the ChEMBL FTP site: [link] Please see ChEMBL_34 release notes for full details of all changes in this rel

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Vaccines Have Saved 154 Million Lives, Mostly Babies, Over Past 50 Years

Drugs.com

MONDAY, April 29, 2024 -- Global vaccination efforts have saved an estimated 154 million lives, including 101 million infants, a new study led by the World Health Organization (WHO) shows.Immunization has contributed more to the health and survival.

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