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Advancements in hit identification for membrane protein drug discovery

Drug Target Review

GPCRs are critical targets for drug development due to their involvement in numerous disease pathologies, with many medications working by either activating or inhibiting these receptors. 2022) Why 90% of clinical drug development fails and how to improve it?, References Sun D, et al. doi:10.1016/j.apsb.2022.02.002.

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Obstacles and innovations of macrocyclic drug development

Drug Target Review

What are macrocycles and why are they interesting for drug discovery? Traditionally, drug discovery has focused on small-molecule therapeutics, typically with a molecular weight of less than 500 Daltons. 1 However, there has recently been an increased interest in so-called beyond rule-of-five compounds, such as macrocycles.