Obstacles and innovations of macrocyclic drug development
Drug Target Review
JANUARY 16, 2025
Food and Drug Administration (FDA) approved drugs, macrocycles are used to combat a range of diseases, including cancer, viral, fungal and bacterial infections, neurodegenerative and autoimmune diseases. 3 Figure 1: Structure of Pep-01, a large macrocycle investigated as a cancer therapeutic targeting the PD1-PDL1 interface.
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