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Advancements in hit identification for membrane protein drug discovery

Drug Target Review

GPCRs are critical targets for drug development due to their involvement in numerous disease pathologies, with many medications working by either activating or inhibiting these receptors. 2022) Why 90% of clinical drug development fails and how to improve it?, References Sun D, et al. doi:10.1016/j.apsb.2022.02.002.

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Target-directed cancer: protein-ligand interactions  

Drug Target Review

We are part of the ICR’s PhD-student programme, which is exciting, because with PhD-student projects we have the ability to probe the more academic questions related to our drug discovery science. I think as a researcher you have to be honest and transparent about your data, and always do the best science that you possibly can do.

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Obstacles and innovations of macrocyclic drug development

Drug Target Review

As computational chemists, medicinal chemists, biophysicists and biologists collaborate closely and combine biophysical data with computational methods, macrocyclic therapeutic development is becoming increasingly feasible and efficient. He has a PhD in Computer Science from Carnegie Mellon University.