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2013) 56, 2059-2073. Capivasertib (orange) bound to the kinase domain of AKT (blue). The figure was generated with CCP4MG (McNicholas et al. Acta Cryst. 2011) D67, 386-394) using PDB ID 4GV1 which was published as part of Addie et al.
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Drug Discovery Today , 18(13-14):659666, 2013. Journal of Medicinal Chemistry , 59(6):23122327, 2016. Yusof I, Segall MD. Considering the impact drug-like properties have on the chance of success. Bhardwaj G, OConnor J, Rettie S, et al. Accurate de novo design of membrane-traversing macrocycles. Cell , 185(19):35203532, 2022.
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