2013 - Drug Discovery Digest

Actithera draws new investors to radiopharma drug pitch

BioPharma Drive: Drug Pricing

JULY 9, 2025

in 2013 — the field has taken off since the success of Novartis’ prostate cancer treatment Pluvicto. The technology works by attaching a radioisotope to a targeting compound via a specially engineered “linker” molecule. While radiopharmaceuticals have been around for years — Bayer’s Xofigo was approved in the U.S.

Drugs

Drugs Clinical Development Therapies Clinical Trials

David Liu receives Breakthrough Prize in Life Sciences

Broad Institute

APRIL 5, 2025

In 2013, Broad founding director Eric S. Since its founding in 2013 by Sergey Brin, Priscilla Chan and Mark Zuckerberg, Yuri and Julia Milner, and Anne Wojcicki, the Breakthrough Prize has been given to standout individuals in life sciences, mathematics, and fundamental physics. Lander was among the inaugural recipients of the prize.

Science

Science Clinical Trials DNA Disease

Designing antibodies to think before they bind

Drug Target Review

JULY 24, 2025

Meet Jhong-Jhe (JJ) You JJ joined AP Biosciences in 2013 as the company’s first employee, leading the development of the Omni-Mab human antibody phage display library and building a robust cell-based assay platform for screening and isolating functional antibodies for immunotherapy.

Immune Response

Immune Response Engineering Cell Based Assays Therapies

Protein degraders: chasing undruggable targets

BioPharma Drive: Drug Pricing

JULY 8, 2025

Since Crews launched Arvinas in 2013, various biotechs have set out with their own spins on the idea, chasing different degrader pathways to the lysosome or proteasome. Cacace, of Arvinas, said those discoveries were “key pieces” that helped companies “bridge to greater tools” and led to oral drug-like molecules. "It

Targeted Protein Degradation

Targeted Protein Degradation Small Molecule Disease Therapies

Labuxtinib

New Drug Approvals

JUNE 14, 2025

Compound 1 can be prepared according to example Fl 10 of WO 2013/033070 Al, which is incorporated by reference herein, as summarized in the Scheme 1 provided below: Scheme 1. 2013-03-07. Compound 1 [0022] As defined above, a pharmaceutical composition of the present invention is a micronized powder comprising Compound 1.

Clinical Development

Clinical Development Pharmaceuticals International

Vamorolone

New Drug Approvals

JULY 25, 2025

The synthesis is disclosed in Bioorganic & Medicinal Chemistry, Volume 21 , Issue 8, 15 April 2013, Pages 2241-2249. 21 (2013) 2241–2249. 2013, 21, 2241− 2249. 2013, 21, 2241−2249. 21 (2013) 2241–2249 Nat. Reeves EK, Hoffman EP, Nagaraju K, Damsker JM, McCall JM (April 2013). October 2013).

FDA

FDA FDA Approval Treatment Clinical Trials

Gene editing extends lifespan in mouse model of prion disease

Broad Institute

JANUARY 14, 2025

Not long after the development of CRISPR-Cas9 gene editing in 2013, Vallabh and Minikel began thinking about whether CRISPR could be used to disrupt the gene encoding the prion protein. The wife-and-husband team started a lab at the Broad with a singular focus: preventing and treating prion disease within their lifetime.

Disease

Disease DNA Protein Production Treatment

Navigating Regulatory Hurdles in Drug Development

DrugBank

JUNE 18, 2025

The FDA restricted its use in 2010, requiring additional studies before partially lifting restrictions in 2013. Initially approved based on short-term efficacy studies, follow-up trials raised concerns about its long-term safety.

Drug Development

Drug Development Clinical Trials Compliance Drugs

Building better brain models for Parkinson’s disease and beyond

Drug Target Review

MARCH 3, 2025

Since 2013, Jens has been the head of the Developmental and Cellular Biology group at the Luxembourg Centre for Systems Biomedicine (LCSB) and a Professor at the University of Luxembourg. He worked as a postdoctoral researcher at the Institute for Molecular Biotechnology in Vienna, Austria.

Disease

Disease Treatment Cell Biology Therapies

The Eternal Life and Art of Maxwell Ardeen

Codon

JUNE 2, 2025

A decade passed before, in 2013 , scientist Mark Post would famously create and consume a burger grown from stem cells. They saw their mission as “a pioneering collaboration that explores how tissue engineering can be used as a medium for artistic expression.”

Engineering

Engineering Therapies DNA Trials

Elacestrant

New Drug Approvals

MAY 9, 2025

2] [4] Pharmacology Pharmacodynamics Elacestrant is an antiestrogen that acts as an antagonist of estrogen receptors , specifically targeting the estrogen receptor alpha (ER), which is the biological target of endogenous estrogens like estradiol. [1] 1] [8] Pharmacokinetics Elacestrant has an oral bioavailability of approximately 10%. [1]

FDA

FDA Pharmacokinetics Therapies Treatment

NERIGLIATIN

New Drug Approvals

JUNE 25, 2025

PAPER [link] PAPER Bioorganic & Medicinal Chemistry Letters (2013), 23(16), 4571-4578 [link] Figure 1. The resulting solid was dried in a vacuum oven overnight to afford the desired material (50.0g) in 81% yield. 1 H NMR (400MHz, CDCl3) δ 9.54 (d, J = 1.56 Hz, 1H), 8.50 (s, 2H), 8.37 (s, 1H), 8.14 (d, J = 0.78 Hz, 1H), 6.28 (t, J = 0.98

Small Molecule

Small Molecule Treatment Regulations Drugs

Syringe services for people who inject drugs are enormously effective, but remain underused

National Institute on Drug Abuse: Nora's Blog

NOVEMBER 25, 2024

Epub 2013 Dec 27. Are needle and syringe programmes associated with a reduction in HIV transmission among people who inject drugs: a systematic review and meta-analysis. Int J Epidemiol. 2014 Feb;43(1):235-48. doi: 10.1093/ije/dyt243. PMID: 24374889.

Drugs

Drugs Treatment Disease Science

Levers for Biological Progress

Codon

NOVEMBER 1, 2024

This technique " opens large windows into the cell’s interior ," according to a 2013 review, allowing visualization of hidden structures that can’t be easily extracted or crystallized. In short, culture is an oft-overlooked bottleneck. 7 Rice varieties from South and South-East Asia were grown next to plots of rice encoding Sub1.

DNA

DNA RNA Molecular Biology Laboratories

CI-CD Deployment On AWS EKS by GitHub Actions

Perficient: Drug Development

JANUARY 30, 2025

Kubernetes was invented by Google in 2013 and was handed over to CNCF (Cloud Native Computing Foundation), which is a part of the Linux Foundation. Kubernetes is an Open Source Container Orchestration tool that automates Containerized Applications’ deployment, scaling, and management.

PRITELIVIR MESYLATE

New Drug Approvals

JULY 8, 2025

WO 2013/045479 Al describes an improved and shortened synthesis process of N-[5- (ammosulfonyl)-4-methyl-l,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetaniide and the mesylate salt thereof by using boronic acid derivatives or borolane reagents while avoiding toxic organic tin compounds. References ^ Wilck, M.B.; Zuckerman, R.A.;

Virus

Virus DNA Clinical Trials Treatment

Incyte replaces CEO Hoppenot with dealmaker Meury

BioPharma Drive: Drug Pricing

JUNE 26, 2025

“During Hervé’s tenure, Incyte launched six novel medicines plus two new indications for Jakafi, expanded commercial operations into Europe, Japan and Canada and grew revenues from $355 million dollars in 2013 to $4.2 billion today.” However, Incyte’s other drugs don’t make it much money.

Therapies

Therapies Licensing Licensing Vaccine

Natural Intelligence?

Molecular Design

DECEMBER 31, 2024

Hampi, November 2013 Having made the disclaimers, Ill open my review of H2024 with some general observations.

Small Molecule

Small Molecule Drugs Production Science

Optical density and absorbance measurements | BMG LABTECH

BMG Labtech

DECEMBER 20, 2024

2013) Cell Viability Assays. Anal Biochem. 1976 72:248-254. doi: 10.1006/abio.1976.9999. Crowther, J.R. Chapter 2: Basic Principles of ELISA. ELISA: Theory and Practice. Humana Press. ISBN 0896032795. Assay Guidance Manual. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences.

DNA

DNA Science Laboratories RNA

When sea stars fall, sea otters rise: Sea otters benefit from prey boom triggered by loss of ochre sea stars

Science Daily: Pharmacology News

APRIL 30, 2025

In 2013, a sea star wasting syndrome decimated populations of Pisaster along the west coast of North America and along the Monterey Peninsula in California, where this study was conducted. The orange and purple stars have a hungry appetite for mussels in the rocky intertidal.

Research

The Great RIF(T): One FDA Division’s Destruction and What it Could Mean for Generic Drugs

FDA Law Blog: Biosimilars

APRIL 8, 2025

OGDP is one of several offices in OGD, and it was composed of three divisions: the Division of Legal and Regulatory Support, the Division of Orange Book Publication and Regulatory Assessment, and the Division of Policy Development (DPD).

FDA

FDA Drugs Production Drug Development

FDA Abandons Its Defense of the LDT Rule, But is It Signaling an Increase in RUO Scrutiny?

FDA Law Blog: Biosimilars

JUNE 2, 2025

The letter, which FDA issued on March 31, 2025 (but only posted on its website last week), was only one of two that FDA has sent in the last five years and only one of five that FDA has issued since finalizing its RUO Guidance in November 2013 (see guidance here ).

FDA

FDA Regulations Laboratories Government

Incyte Names Bill Meury as CEO as Hervé Hoppenot Announces Retirement

The Pharma Data

JUNE 26, 2025

Revenue growth from $355 million in 2013 to $4.2 Two new indications added to Jakafi , further extending its clinical utility. Geographic expansion into Europe, Japan, and Canada, establishing Incyte as a global player. billion in 2024 , reflecting consistent commercial execution and portfolio expansion.

Production

Production Science Government International

New Report on Patent Litigation Settlements Says that they are Critically Necessary to Ensure Prompt Generic and Biosimilar Market Entry

FDA Law Blog: Biosimilars

JUNE 26, 2025

Actavis decision in 2013 total $423 billion, and the average savings to the healthcare system per molecule are $5 billion.” We all know that time is money. The IQVIA Institute report shows just how much money: “Savings to the healthcare system from patent settlements since the FTC v.

Biosimilars

Biosimilars Marketing Production Drugs

Chiglitazar

New Drug Approvals

JULY 28, 2025

2013, 15, 347−352. .; Lemaire, M. Straightforward heterogeneous palladium catalyzed synthesis of aryl ethers and aryl amines via a solvent free aerobic and non-aerobic dehydrogenative arylation. Green Chem. 132) Lu, X.; Method for preparing phenylalanine compound. Patent US 10640465 B2, 2020. AS ON JUNE2025 4.45

Trials

Trials Regulations Clinical Trials Production

Patent box tax incentives pharmaceutical innovation

Drug Patent Watch

MAY 7, 2025

The Patent Box tax regime, introduced in the UK in 2013, has been hailed as a success in fostering a culture of R&D and entrepreneurship. As the pharmaceutical industry continues to drive groundbreaking research and development, a lesser-known tax incentive has emerged as a key catalyst for innovation.

Pharmaceuticals

Pharmaceuticals Production Research

Teen Lifestyles Were Less Healthy in 2023 Compared to 2013, CDC Report Shows

Drugs.com

JANUARY 16, 2025

THURSDAY, Jan. 16, 2025 -- U.S. teenagers still struggle to make healthy choices when it comes to diet, exercise and sleep, a new Centers for Disease Control and Prevention report says.Specifically, the percentage of students eating healthy.

Disease

Into the Ashtray: FDA’s Previous Proposal to Ban Menthol Cigarettes

FDA Law Blog: Biosimilars

FEBRUARY 12, 2025

44,484 (July 24, 2013). As an aside, TPSAC and its 2011 report were not without controversy; although later overturned by the D.C.

FDA

FDA Production Regulations

Substance Use Testing and State/Federal Benefits

Common Sense for Drug Policy Blog

JULY 21, 2025

9 Additionally, lawmakers in a majority of states reportedly proposed legislation in 2011, 2012, 2013, and/or 2014 that would require drug testing beneficiaries of governmental assistance under certain circumstances, while at least 12 state governments over that time have enacted such legislation.

Government

Government Drugs Research

Non-stop flight: 4,200 km transatlantic flight of the Painted Lady butterfly mapped

Science Daily: Pharmacology News

JUNE 25, 2024

In October 2013 a researcher made a surprising discovery of Painted Lady Butterflies on the Atlantic beaches of French Guiana -- a species not typically found in South America. This unusual sighting prompted an international study to investigate the origin of these butterflies.

International

International Research

In Every U.S. State, at Least 1 in 5 People Is Now Obese

Drugs.com

SEPTEMBER 12, 2024

2013, not one state had an adult obesity rate topping 35%, but 10. THURSDAY, Sept. 12, 2024 -- Statistics from 2023 on U.S. obesity rates bring no good news: In every state in the nation, 1 in every 5 people is now obese, the new tally shows.In

Overactive Bladder Diagnoses Tripled, but Treatment Is Still Rare

Drugs.com

JANUARY 22, 2025

22, 2025 -- A sudden need to urinate is more common than previously known, but treatment is less common.Diagnoses for overactive bladder more than tripled between 2013 and 2017, after the American Urological Association (AUA). WEDNESDAY, Jan.

Treatment

Americans Short on Sleep, Stressed Out About It: Poll

Drugs.com

APRIL 15, 2024

This is nearly a reversal of the figures last measured in 2013, MONDAY, April 15, 2024 -- While more than half of Americans say they would feel better with more sleep, only 42% say they are getting as much shut-eye as they need, a new poll finds."This

Direct RAS inhibitors turn 10

Covalent Modifiers

JULY 30, 2024

Here we provide a personal perspective on the effort leading to our initial report of KRASG12C inhibitors in 2013, and the decade of discoveries that followed. [link] RAS proteins, central drivers of cancer, appeared ‘undruggable’ for almost 30 years. Direct RAS inhibitors turn 10

Swift Use of Antiretrovirals in Infected Newborns Can Banish HIV

Drugs.com

DECEMBER 11, 2023

11, 2023 -- When an HIV-infected child known as the 'Mississippi baby' was given powerful antiretroviral drugs within hours of birth in 2013 and then appeared to be rid of HIV, people wondered if it might be replicated in other. MONDAY, Dec.

Drugs

Targeting KRAS Diversity: Covalent Modulation of G12X and Beyond in Cancer Therapy

Covalent Modifiers

APRIL 18, 2024

In 2013, Shokat and co-workers achieved a groundbreaking feat by covalently targeting a previously undiscovered allosteric pocket (switch II pocket (SWIIP)) of KRASG12C. This breakthrough led to the development and approval of sotorasib (AMG510) and adagrasib (MRTX849), revolutionizing the treatment of KRASG12C-dependent lung cancer.

Therapies

Therapies Treatment

Greenhouse gas emissions at 'an all-time high' -- and it is causing an unprecedented rate of global warming, say scientists

Science Daily: Pharmacology News

JUNE 8, 2023

C for the most recent decade (2013 to 2022) above pre-industrial levels. Human-induced warming, largely caused by the burning of fossil fuels, reached an average of 1.14°C This is up from 1.07°C C between 2010 and 2019. Human-induced warming is now increasing at a pace of over 0.2°C C per decade.

Early Treatment Can Push HIV Into Remission in Kids: Study

Drugs.com

MARCH 8, 2024

FRIDAY, March 8, 2024 -- Ever since one child, dubbed the 'Mississippi baby,' went into drug-free remission of HIV in 2013, experts have wondered if giving treatment within hours of birth might do the same for others.The results of a new trial.

Treatment

Treatment Trials Drugs

Prevalence of Depression Increased Over Last Decade

Drugs.com

APRIL 22, 2025

percent, a 60 percent increase from 2013-2014, according to an April data brief published by the. TUESDAY, April 22, 2025 -- The prevalence of depression among adolescents and adults aged 12 years and older during August 2021 to August 2023 was 13.1

Landscape of In Silico Tools for Modeling Covalent Modification of Proteins: A Review on Computational Covalent Drug Discovery

Covalent Modifiers

FEBRUARY 6, 2024

However, there has been a resurgence in covalent drug design following the success of several covalent drugs such as boceprevir (2011), ibrutinib (2013), neratinib (2017), dacomitinib (2018), zanubrutinib (2019), and many others.

Drugs

Drugs Research

Buprenorphine now replaces methadone as the most common medicine for opioid dependence’: 10-year trends in opioid agonist treatment medicines in Australia

National Drug & Alcohol Research Centre Blog

DECEMBER 4, 2023

We converted information on monthly sales of methadone, sublingual buprenorphine (+/- naloxone) and buprenorphine between 2013 and 2022 into an estimate of the number of clients receiving these medicines each month, based on average doses in Australia (“client-months”). Chidwick, K., Farrell, M., & Degenhardt, L. Vol 123, p.

Treatment

Treatment Community Pharmacies Pharmacy International

Women in Military More Likely to Suffer Chronic Pain During Wartime

Drugs.com

JULY 8, 2024

MONDAY, July 8, 2024 -- Wartime appears to increase the risk of chronic pain for military women, a new study suggests.Active-duty servicewomen who served between 2006 and 2013 – a period of heightened combat deployments – had a significantly inc.

C3G kidney disease: How is it diagnosed and how is it treated?

Antidote

OCTOBER 3, 2022

Complement 3 Glomerulopathy, most commonly shortened to C3G or C3G kidney disease, is a rare type of kidney disease that has only been diagnosed since 2013. “C3” C3” refers to a blood protein that has a vital role in the immune system, and “G” is for the damage to glomeruli in the kidneys.

Disease

Drug-induced long QT syndrome: Concept and non-clinical models for predicting the onset of drug-induced torsade de pointes in patients in compliance with ICH E14/S7B guidance [Minireview]

ASPET

AUGUST 21, 2024

In response, Comprehensive In Vitro Proarrhythmia Assay (CiPA) and Exposure-Response Modeling were proposed in 2013 to reinforce proarrhythmic risk assessment. However, those guidelines unfortunately hampered the development of some potentially valuable drug candidates despite not being proven to be proarrhythmic.

Compliance

Compliance Pharmacokinetics Drugs Engineering

Actithera draws new investors to radiopharma drug pitch

David Liu receives Breakthrough Prize in Life Sciences

Trending Sources

Designing antibodies to think before they bind

Protein degraders: chasing undruggable targets

Labuxtinib

Vamorolone

Gene editing extends lifespan in mouse model of prion disease

Navigating Regulatory Hurdles in Drug Development

Building better brain models for Parkinson’s disease and beyond

The Eternal Life and Art of Maxwell Ardeen

Elacestrant

NERIGLIATIN

Syringe services for people who inject drugs are enormously effective, but remain underused

Levers for Biological Progress

CI-CD Deployment On AWS EKS by GitHub Actions

PRITELIVIR MESYLATE

Incyte replaces CEO Hoppenot with dealmaker Meury

Natural Intelligence?

Optical density and absorbance measurements | BMG LABTECH

When sea stars fall, sea otters rise: Sea otters benefit from prey boom triggered by loss of ochre sea stars

The Great RIF(T): One FDA Division’s Destruction and What it Could Mean for Generic Drugs

FDA Abandons Its Defense of the LDT Rule, But is It Signaling an Increase in RUO Scrutiny?

Incyte Names Bill Meury as CEO as Hervé Hoppenot Announces Retirement

New Report on Patent Litigation Settlements Says that they are Critically Necessary to Ensure Prompt Generic and Biosimilar Market Entry

Chiglitazar

Patent box tax incentives pharmaceutical innovation

Teen Lifestyles Were Less Healthy in 2023 Compared to 2013, CDC Report Shows

Into the Ashtray: FDA’s Previous Proposal to Ban Menthol Cigarettes

Substance Use Testing and State/Federal Benefits

Non-stop flight: 4,200 km transatlantic flight of the Painted Lady butterfly mapped

In Every U.S. State, at Least 1 in 5 People Is Now Obese

Overactive Bladder Diagnoses Tripled, but Treatment Is Still Rare

Americans Short on Sleep, Stressed Out About It: Poll

Direct RAS inhibitors turn 10

Swift Use of Antiretrovirals in Infected Newborns Can Banish HIV

Targeting KRAS Diversity: Covalent Modulation of G12X and Beyond in Cancer Therapy

Greenhouse gas emissions at 'an all-time high' -- and it is causing an unprecedented rate of global warming, say scientists

Early Treatment Can Push HIV Into Remission in Kids: Study

Prevalence of Depression Increased Over Last Decade

Landscape of In Silico Tools for Modeling Covalent Modification of Proteins: A Review on Computational Covalent Drug Discovery

Buprenorphine now replaces methadone as the most common medicine for opioid dependence’: 10-year trends in opioid agonist treatment medicines in Australia

Women in Military More Likely to Suffer Chronic Pain During Wartime

C3G kidney disease: How is it diagnosed and how is it treated?

Drug-induced long QT syndrome: Concept and non-clinical models for predicting the onset of drug-induced torsade de pointes in patients in compliance with ICH E14/S7B guidance [Minireview]

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