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Advancements in hit identification for membrane protein drug discovery

Drug Target Review

PoLiPa technology Domainex’s Polymer Lipid Particle (PoLiPa) technology offers a versatile, detergent-free platform for the rapid, high-purity preparation of membrane proteins like GPCRs, ion channels and solute carriers, enabling assay development for these challenging targets. References Sun D, et al.

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High Throughput Screening (HTS)

Sygnature Discovery

Sygnature Discovery offers high throughput screening along with additional hit identification tools including virtual screening, knowledge-based design, and fragment screening. The process begins with assay development or transfer.

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Target-directed cancer: protein-ligand interactions  

Drug Target Review

We support the drug discovery projects of the CCDD with assay development and screening, biophysics, structural biology and recombinant protein production. In terms of compound libraries, we have a high-throughput screening library of about 200,000 ligands. We can screen with many different formats and modalities.

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Biophysics

Sygnature Discovery

Comprehensive Assay Development for Diverse Applications Our team here at Sygnature Discovery, comprised of expert biophysicists, is highly experienced in a variety of target classes and drug modalities. Sygnature Discovery’s Biophysical Assay Development Capabilities: 1.