Cell Based Assays Clinical Development Immune Response 
Drug Target Review
JULY 24, 2025
CD137 is a receptor on T cells that boosts their activity, but only when clustered. By designing the antibody to activate CD137 only in the presence of p95HER2, the team created a more controlled immune response and reduced the risk of off-target effects. This balance supports immune response while limiting potential toxicity.
Agency IQ
APRIL 12, 2024
As a product is refined during development and/or as additional properties about a product are discovered, more sophisticated tools are required to better understand its impact on cellular processes and systems within the body. morphological cell changes or alterations in protein production or expression).
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