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How GPCR-targeting therapies are advancing the fight against inflammatory disease

Drug Target Review

All these features make GPCRs central to regulating many vital biological processes in the body, including immune responses and inflammation, and thus especially attractive for therapeutic intervention. GPCR-targeting therapies such as DT-9046 represent a compelling opportunity in that respect, with major clinical and commercial potential.

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Addressing increasingly resistant drugs by infectious agents

Drug Target Review

7,9 Dihydrofolate reductase-thymidylate synthase (DHFR) have been successfully exploited for the therapy of bacterial infections and other parasitic diseases such as malaria. 2018): Silent Information Regulator 2 from Trypanosoma cruzi is a potential target to infection control, IntechOpen. 12(11): e0006980. Nilmar, S. and Anabela, C.

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