Broad Institute

MAY 21, 2025

In the 1990s, Michel Sadelain then at Memorial Sloan Kettering Cancer Center (MSKCC) designed CARs by combining fragments of tumor-recognizing antibodies with the molecular machinery found in T-cell receptors. Sadelain and Rivire also developed safe and reliable ways to produce these cells for use in patients.

Therapies 119

Therapies FDA Approval Engineering Immune Response 119

Drug Target Review

NOVEMBER 17, 2023

NK cells are among the front line of protection from infected and abnormal cells as part of the ‘innate immune response’. They recognise ‘cell stress molecules’ on the surface of infected, old, injured and cancerous cells without the need for complex pre-stimulation signals of the adaptive immune system (eg, T cells).

Therapies 118

Therapies Clinical Trials Cell Biology Trials 118

The Pharma Data

DECEMBER 31, 2020

“Antibody responses are not likely to be the sole determinant of someone’s outcome,” said Scott Boyd, associate professor of pathology at Stanford. Some of these patients mount a vigorous immune response, and others have a more moderate response. There are also other branches of the immune system involved.

Research 52

Research Virus Immune Response Cell Biology 52