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Advancements in hit identification for membrane protein drug discovery

Drug Target Review

PoLiPa detergent-free stabilisation of membrane proteins enables the application of fragment-based screening to GPCRs, expanding the methods possible targets and opening the potential to develop novel therapeutics agents as a result. 2023) Biochemistry, G protein coupled receptors , StatPearls [Internet]. Jones EM, et al.

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Silly Things Large Language Models Do With Molecules

Practical Cheminformatics

Testing Claude’s Molecule Generation Ability To test the molecule generation ability of Claude, a general-purpose LLM from Anthropic, I prompted it to generate analogs for hits from fragment screens. These fragment hits are small molecules with between 11 and 21 heavy atoms. However, there were also plenty of silly analogs.

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Biophysical Technologies

Sygnature Discovery

Our in-house SPR equipment comprises: 2x Biacore TM 8K+ 3x Biacore TM 8K 1x Biacore TM T200 This covers mM binders, such as fragments, through to sub pM interactions (such as late stage small molecules or very high affinity biological interactions, Tollenaere et al 2023 [link] ).