Drug Target Review

APRIL 7, 2025

PoLiPa detergent-free stabilisation of membrane proteins enables the application of fragment-based screening to GPCRs, expanding the methods possible targets and opening the potential to develop novel therapeutics agents as a result. 2023) Biochemistry, G protein coupled receptors , StatPearls [Internet]. Jones EM, et al.

Fragment Screening 52

Fragment Screening Drugs Biophysical Assays Small Molecule 52

Practical Cheminformatics

OCTOBER 8, 2024

Testing Claude’s Molecule Generation Ability To test the molecule generation ability of Claude, a general-purpose LLM from Anthropic, I prompted it to generate analogs for hits from fragment screens. These fragment hits are small molecules with between 11 and 21 heavy atoms. However, there were also plenty of silly analogs.

Fragment Screening 125

Fragment Screening Packaging Organic Chemistry Small Molecule 125

Sygnature Discovery

JUNE 17, 2024

Our in-house SPR equipment comprises: 2x Biacore TM 8K+ 3x Biacore TM 8K 1x Biacore TM T200 This covers mM binders, such as fragments, through to sub pM interactions (such as late stage small molecules or very high affinity biological interactions, Tollenaere et al 2023 [link] ).

Small Molecule 52

Small Molecule Fragment Screening DNA Science 52