2023 - Drug Discovery Digest

Climate-change-triggered 2023 mega-landslide caused Earth to vibrate for nine days

Science Daily: Pharmacology News

SEPTEMBER 12, 2024

The study concluded that this movement of water was the cause of a mysterious, global seismic signal that lasted for nine days and puzzled seismologists in September 2023.

2023 was the hottest summer in two thousand years

Science Daily: Pharmacology News

MAY 14, 2024

Researchers have found that 2023 was the hottest summer in the Northern Hemisphere in the past two thousand years, almost four degrees warmer than the coldest summer during the same period.

Research

Record heat in 2023 worsened global droughts, floods and wildfires

Science Daily: Pharmacology News

JANUARY 11, 2024

Record heat across the world profoundly impacted the global water cycle in 2023, contributing to severe storms, floods, megadroughts and bushfires, new research shows.

Research

Climate change raised the odds of unprecedented wildfires in 2023-24

Science Daily: Pharmacology News

AUGUST 13, 2024

The State of Wildfires report takes stock of extreme wildfires of the 2023-2024 fire season (March 2023-February 2024), explains their causes, and assesses whether events could have been predicted. It also evaluates how the risk of similar events will change in future under different climate change scenarios.

NASA analysis confirms 2023 as warmest year on record

Science Daily: Pharmacology News

JANUARY 14, 2024

Earth's average surface temperature in 2023 was the warmest on record, according to an analysis by NASA. Global temperatures last year were around 2.1 degrees Fahrenheit (1.2 degrees Celsius) above the average for NASA's baseline period (1951-1980), scientists from NASA's Goddard Institute for Space Studies (GISS) in New York reported.

U.S. Gun Injury Rates in 2023 Topped Pre-Pandemic Levels

Drugs.com

JUNE 21, 2024

FRIDAY, June 21, 2024 -- For the fourth year in a row, rates of gun injuries stayed above levels seen before the pandemic, a new government report shows.Race played a key role in who saw those higher rates of gun violence in 2023, the researchers.

Government

Government Research

CDD Vault Update (September 2023)

Collaborative Drug

SEPTEMBER 28, 2023

Fun with Ketcher New keyboard shortcuts have been added to the structure editor. Cycle through menu options and easily lookup abbreviations while still being able to assign the same atom to multiple locations.

CDD Vault Update (November 2023)

Collaborative Drug

NOVEMBER 3, 2023

Handling Non-Numeric Values in a Data Import File Often, data files which are being imported into CDD Vault will contain certain text values in columns that are being mapped to numeric fields/readouts. Examples include “ND” for “Not Determined” or “N/A” for “Not Applicable”.

U.S. Births Declined in 2023, Marking End to Post-Pandemic Rise

Drugs.com

APRIL 25, 2024

births may be over, with 2023 numbers showing a decline in births.According to provisional data from the U.S. THURSDAY, April 25, 2024 -- The short post-pandemic uptick in U.S. Centers for Disease Control and Prevention, just under 3.6

Disease

CDD Vault Update (December 2023)

Collaborative Drug

DECEMBER 19, 2023

The Research Informatics and Development groups at CDD are continually developing computational tools within CDD Vault to help accelerate drug discovery. The newest addition to this suite of features is a novel Deep Learning model to aid medicinal chemists.

Research

Research Drugs

CDD Vault Update (October 2023)

Collaborative Drug

OCTOBER 16, 2023

Keyword Searching When using the Keywords search feature in the main Explore Data > Search tab, there is a new “exact” search option available when you select a specific, non-numeric Molecule or Batch field.

2023 CDD Holiday Poem (with ChatGPT)

Collaborative Drug

DECEMBER 1, 2023

Dear CDD community: As we’ve been publishing annual CDD holiday poems for years, there was sufficient content as a “training set” covering the meaning and voice for ChatGPT to capture the spirit. Our new deep learning algorithm securely identifies structures and public structures similar to your own private molecules.

Alzheimer’s Drug, Leqembi, Can Be Safely Administered In Memory Clinics, Study Says

Drugs.com

MAY 15, 2025

THURSDAY, May 15, 2025 — The 2023 approval of the first drug shown to slow the progression of Alzheimer’s disease came with no small amount of concern from skeptics. Lecanemab (Leqembi) modestly slows Alzheimer’s by helping the.

Drugs

Drugs Disease

Drug Discovery Industry Roundup with Barry Bunin — December 18, 2023

Collaborative Drug

DECEMBER 18, 2023

Discover the impact of 'junk DNA' on cancer, teen obesity treatments, Neanderthal genes on sleep patterns, and Nobel discoveries shaping medicine

DNA

DNA Treatment Drugs

Summer of 2023 Was Hottest in 2,000 Years

Drugs.com

MAY 14, 2024

TUESDAY, May 14, 2024 -- High temperatures across the Northern Hemisphere last summer were scorching and frequent enough to make it the hottest summer in two millennia, new research shows.Weather records based on scientific instruments only goes.

Research

Teen Lifestyles Were Less Healthy in 2023 Compared to 2013, CDC Report Shows

Drugs.com

JANUARY 16, 2025

THURSDAY, Jan. 16, 2025 -- U.S. teenagers still struggle to make healthy choices when it comes to diet, exercise and sleep, a new Centers for Disease Control and Prevention report says.Specifically, the percentage of students eating healthy.

Disease

U.S. Adult Obesity Rate Fell in 2023, as Use of GLP-1 Meds Rose

Drugs.com

DECEMBER 13, 2024

FRIDAY, Dec. 13, 2024 -- The U.S. obesity rate declined for the first time in a decade last year, coinciding with the rise of GLP-1 weight-loss meds, a new study finds. Data on almost 17 million adults nationwide showed the obesity rate -- which.

Ocean-surface warming four times faster now than late-1980s

Science Daily: Pharmacology News

JANUARY 28, 2025

The study helps explain why 2023 and early 2024 saw unprecedented ocean temperatures.

Unprecedented ocean heating shows risks of a world 3°C warmer

Science Daily: Pharmacology News

JANUARY 31, 2024

New research examines the causes of the record-breaking ocean temperatures witnessed in 2023.

Research

10 clinical trials to watch in the second half of 2024

BioPharma Drive: Drug Pricing

JULY 1, 2024

Study results are expected for a pair of closely watched obesity drugs, while key tests await for a high-priced AbbVie acquisition and one of 2023’s largest IPOs.

Clinical Trials

Clinical Trials Trials Drugs

NASA data shows July 22, 2024 was Earth's hottest day on record

Science Daily: Pharmacology News

JULY 29, 2024

July 21 and 23 of this year also exceeded the previous daily record, set in July 2023. July 22, 2024, was the hottest day on record, according to a NASA analysis of global daily temperature data. These record-breaking temperatures are part of a long-term warming trend driven by human activities, primarily the emission of greenhouse gases.

Long-Acting, Injected HIV Meds Can Help Tough-to-Treat Patients

Drugs.com

JULY 5, 2023

WEDNESDAY, July 5, 2023 -- For nearly three decades, daily antiretroviral pills have offered patients living with HIV a highly effective way to keep their infection under control. But some patients, particularly those beset by homelessness, drug.

Drugs

Common Stomach Bug Is Linked to Higher Alzheimer's Risk

Drugs.com

DECEMBER 28, 2023

28, 2023 -- A common stomach bug may play a part in Alzheimer's disease risk.New research found that older folks infected with Helicobacter pylori (H. THURSDAY, Dec. pylori) had greater odds for developing Alzheimer's, the most common type of.

Disease

Disease Research

JPM24: Pfizer’s tough sell, the next Karuna and building a biotech platform

BioPharma Drive: Drug Pricing

JANUARY 9, 2024

Albert Bourla acknowledged Pfizer’s difficult 2023, while a biotech CEO spoke with BioPharma Dive about building neuroscience startups.

Greenland mega-tsunami led to week-long oscillating fjord wave

Science Daily: Pharmacology News

AUGUST 9, 2024

In September 2023, a megatsunami in remote eastern Greenland sent seismic waves around the world, piquing the interest of the global research community. The event created a week-long oscillating wave in Dickson Fjord, according to a new report in The Seismic Record.

Research

Wildfire Smoke Flooded ERs With Asthma Cases

Drugs.com

MAY 5, 2025

MONDAY, May 5, 2025 -- Asthma attacks caused emergency room surges during the 2023 Canadian wildfires, with smoke-filled air sending hundreds to the hospital daily, a new study says.Daily asthma-related visits to Ontario hospitals increased nearly.

Hospitals

New A-Fib Ablation Therapy Benefits Women as Much as Men

Drugs.com

NOVEMBER 3, 2023

2, 2023 -- A procedure to treat the irregular heart rhythm condition known as atrial fibrillation (a-fib) works just as well for women as it does for men, new research shows. THURSDAY, Nov. The technology, called pulsed field ablation (PFA), can be.

Therapies

Therapies Research

Rheumatoid Arthritis Drug, Baricitinib (Olumiant), Could Put Brakes on Type 1 Diabetes

Drugs.com

DECEMBER 7, 2023

7, 2023 -- A drug long used to curb rheumatoid arthritis may be a potent foe against another immune disorder, type 1 diabetes. THURSDAY, Dec. Australian researchers report that baricitinib (Olumiant) appears to help patients newly diagnosed with.

Drugs

Drugs Research

Falling Vaccination Rates Brings Spikes in Measles Worldwide

Drugs.com

NOVEMBER 15, 2024

million people struck by the preventable illness in 2023, health officials reported Wednesday."Inadequate FRIDAY, Nov. 15, 2024 -- Waning vaccine coverage has fueled a 20% spike in measles cases worldwide, with 10.3 Inadequate immunization coverage globally.

Vaccine

New Antibiotic, Zoliflodacin, Seeking Approval, Tackles Drug-Resistant Gonorrhea in Trial

Drugs.com

NOVEMBER 3, 2023

3, 2023 -- The first new antibiotic for gonorrhea — the second most common sexually transmitted disease — has shown promise in a clinical trial. FRIDAY, Nov. That news should come as a relief to public health experts, because gonorrhea.

Trials

Trials Clinical Trials Disease Drugs

Record low Antarctic sea ice 'extremely unlikely' without climate change

Science Daily: Pharmacology News

MAY 20, 2024

Scientists have found that the record-low levels of sea ice around Antarctica in 2023 were extremely unlikely to happen without the influence of climate change. This low was a one-in-a-2000-year event without climate change and four times more likely under its effects.

Astronomers track bubbles on star's surface in most detailed video yet

Science Daily: Pharmacology News

SEPTEMBER 11, 2024

The images of the star, R Doradus, were obtained in July and August 2023. Astronomers have captured images of a star other than the Sun in enough detail to track the motion of bubbling gas on its surface.

FDA Approves Landmark Sickle Cell Gene Therapies, Casgevy and Lyfgenia

Drugs.com

DECEMBER 8, 2023

8, 2023 -- The U.S. FRIDAY, Dec. Food and Drug Administration on Friday approved two milestone gene therapies for sickle cell disease, including the first treatment ever approved that uses gene-editing technology. Casgevy, developed by Vertex.

FDA Approval

FDA Approval Therapies FDA Treatment

FDA Adds Warning to Ozempic Label About Risk for Blocked Intestines

Drugs.com

SEPTEMBER 27, 2023

27, 2023 -- Ozempic, a type 2 diabetes drug that has increasingly been used to help with weight loss, will now be labeled as having the potential to block intestines. WEDNESDAY, Sept. Food and Drug Administration recently made the label.

FDA

FDA Drugs

Eye Drop Recalls: What You Need to Know

Drugs.com

DECEMBER 21, 2023

21, 2023 -- Dozens of over-the-counter lubricating eyedrops and artificial tears faced recall in 2023, due to contamination and unsafe manufacturing practices.“This THURSDAY, Dec. This year, we've seen an especially large number of recalls in.

Learn the Differences Between Hepatitis A, B, C, D & E

Drugs.com

JULY 6, 2023

THURSDAY, July 6, 2023 -- Curious about what the differences are between hepatitis A, B, C, D and E? If so, you’ve come to the right place. Here, experts break down hepatitis infection by type to reveal what it is, the most common symptoms, how.

Bats Don't Get Cancer, and Scientists Are Closer to Understanding Why

Drugs.com

SEPTEMBER 20, 2023

20, 2023 -- Bats have an extraordinary ability to avoid cancer and handle infections, and researchers now think they might know why. WEDNESDAY, Sept. Specific genetic adaptations caused by rapid evolution have made bats extremely cancer-resistant,

Research

Marijuana Use Increasingly Linked to Addiction, Psychosis

Drugs.com

DECEMBER 27, 2023

27, 2023 (HealthDay news) -- A rising tide of cannabis-related mental health problems is resulting from the widespread legalization of recreational weed in the United States, warns a new evidence review.Nearly one in five Americans. WEDNESDAY, Dec.

Bagged, Precut Onions Tied to Salmonella Illnesses in 22 States

Drugs.com

OCTOBER 25, 2023

25, 2023 – Federal regulators are investigating a salmonella outbreak linked to packaged, diced onions that has sickened at least 73 people across 22 states. WEDNESDAY, Oct. Fifteen of the illnesses were so bad that people required.

Packaging

Packaging Regulations

Diabetes Meds Like Ozempic, Mounjaro Might Also Lower Risks for Colon Cancer

Drugs.com

DECEMBER 8, 2023

8, 2023 -- Could blockbuster diabetes and weight-loss meds such as Ozempic, Wegovy, Mounjaro and Zepbound also lower users' odds for colon cancer? FRIDAY, Dec. New research suggests they might.All of these medications (and more) fall into a class.

Research

Marijuana Should Be Moved to Lower-Risk Drug Category, U.S. Health Officials Say

Drugs.com

AUGUST 31, 2023

31, 2023 – The U.S. THURSDAY, Aug. Department of Health and Human Services has asked the U.S. Drug Enforcement Agency to reclassify marijuana as a less dangerous drug under the Controlled Substances Act, a move that could potentially expand.

Drugs

AHA News: Beat the Heat With Hydrating Foods This Summer

Drugs.com

JUNE 20, 2023

TUESDAY, June 20, 2023 (American Heart Association News) -- Staying hydrated can help you live a longer, healthier life. But drinking multiple glasses of water throughout the day isn't for everyone. Health experts say that's OK. While fluids are.

Opioid OD Rescue Drug Narcan Will Reach Drug Store Shelves Next Week

Drugs.com

AUGUST 30, 2023

30, 2023 -- Narcan, a lifesaving medication that reverses opioid overdose, will be available on U.S. WEDNESDAY, Aug. drugstore shelves and online starting next week. People who want to carry Narcan, the nasal spray version of naloxone, will be able.

Drugs

STD Specialists Warn of Shortage of Vital Syphilis Drug, Bicillin L-A

Drugs.com

DECEMBER 4, 2023

4, 2023 -- As syphilis cases surge across America, a group representing the nation's STD specialists says members are reporting shortages of a drug essential to fighting the disease. MONDAY, Dec. In a survey from the National Coalition of STD.

Drugs

Drugs Disease

Climate-change-triggered 2023 mega-landslide caused Earth to vibrate for nine days

2023 was the hottest summer in two thousand years

Trending Sources

Record heat in 2023 worsened global droughts, floods and wildfires

Climate change raised the odds of unprecedented wildfires in 2023-24

NASA analysis confirms 2023 as warmest year on record

U.S. Gun Injury Rates in 2023 Topped Pre-Pandemic Levels

CDD Vault Update (September 2023)

CDD Vault Update (November 2023)

U.S. Births Declined in 2023, Marking End to Post-Pandemic Rise

CDD Vault Update (December 2023)

CDD Vault Update (October 2023)

2023 CDD Holiday Poem (with ChatGPT)

Alzheimer’s Drug, Leqembi, Can Be Safely Administered In Memory Clinics, Study Says

Drug Discovery Industry Roundup with Barry Bunin — December 18, 2023

Summer of 2023 Was Hottest in 2,000 Years

Teen Lifestyles Were Less Healthy in 2023 Compared to 2013, CDC Report Shows

U.S. Adult Obesity Rate Fell in 2023, as Use of GLP-1 Meds Rose

Ocean-surface warming four times faster now than late-1980s

Unprecedented ocean heating shows risks of a world 3°C warmer

10 clinical trials to watch in the second half of 2024

NASA data shows July 22, 2024 was Earth's hottest day on record

Long-Acting, Injected HIV Meds Can Help Tough-to-Treat Patients

Common Stomach Bug Is Linked to Higher Alzheimer's Risk

JPM24: Pfizer’s tough sell, the next Karuna and building a biotech platform

Greenland mega-tsunami led to week-long oscillating fjord wave

Wildfire Smoke Flooded ERs With Asthma Cases

New A-Fib Ablation Therapy Benefits Women as Much as Men

Rheumatoid Arthritis Drug, Baricitinib (Olumiant), Could Put Brakes on Type 1 Diabetes

Falling Vaccination Rates Brings Spikes in Measles Worldwide

New Antibiotic, Zoliflodacin, Seeking Approval, Tackles Drug-Resistant Gonorrhea in Trial

Record low Antarctic sea ice 'extremely unlikely' without climate change

Astronomers track bubbles on star's surface in most detailed video yet

FDA Approves Landmark Sickle Cell Gene Therapies, Casgevy and Lyfgenia

FDA Adds Warning to Ozempic Label About Risk for Blocked Intestines

Eye Drop Recalls: What You Need to Know

Learn the Differences Between Hepatitis A, B, C, D & E

Bats Don't Get Cancer, and Scientists Are Closer to Understanding Why

Marijuana Use Increasingly Linked to Addiction, Psychosis

Bagged, Precut Onions Tied to Salmonella Illnesses in 22 States

Diabetes Meds Like Ozempic, Mounjaro Might Also Lower Risks for Colon Cancer

Marijuana Should Be Moved to Lower-Risk Drug Category, U.S. Health Officials Say

AHA News: Beat the Heat With Hydrating Foods This Summer

Opioid OD Rescue Drug Narcan Will Reach Drug Store Shelves Next Week

STD Specialists Warn of Shortage of Vital Syphilis Drug, Bicillin L-A

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