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Biophysics

Sygnature Discovery

Comprehensive Assay Development for Diverse Applications Our team here at Sygnature Discovery, comprised of expert biophysicists, is highly experienced in a variety of target classes and drug modalities. Sygnature Discovery’s Biophysical Assay Development Capabilities: 1.

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Advancements in hit identification for membrane protein drug discovery

Drug Target Review

PoLiPa technology Domainex’s Polymer Lipid Particle (PoLiPa) technology offers a versatile, detergent-free platform for the rapid, high-purity preparation of membrane proteins like GPCRs, ion channels and solute carriers, enabling assay development for these challenging targets.

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Target-directed cancer: protein-ligand interactions  

Drug Target Review

We support the drug discovery projects of the CCDD with assay development and screening, biophysics, structural biology and recombinant protein production. Although we are an academic centre we work very much like industry. The team that I lead within the CCDD is called the Hit Discovery and Structural Design Team.