Cell Based Assays Information Small Molecule 
Broad Institute
JUNE 30, 2023
It then extracts features from images of stained cells and creates cellular profiles, categorizing cells based on patterns (often imperceptible to the human eye) that they share with other cells, which directly inform disease biology. Credit: Phil Kubitz, Claussnitzer lab Fat cells stained blue to show nuclei.
PerkinElmer
SEPTEMBER 8, 2019
Following the announcement that PerkinElmer has acquired Cisbio Bioassays , here is a little more information about the exciting opportunities this brings to life sciences researchers. The structure of HTRF reagents also makes assays highly resistant to most experimental conditions, and particularly well suited for cell-based assays.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
PerkinElmer
JANUARY 7, 2020
Here are two predictions for the future: Alpha CETSA ® for target engagement While traditional assay methods detect either the displacement of a radioligand binding to the target by a competitor molecule, or the modulation of some function of the target, a new method is making headway: Cellular Thermo Shift Assay (CETSA) from Pelago Bioscience.
Broad Institute
JUNE 21, 2023
The researchers also looked at the tool’s ability to detect changes in cell morphology after exposure to drugs and small molecule compounds. With high-resolution, cell-based profiling techniques, extracting large numbers of data can be done cheaply and efficiently.
Molecular Design
DECEMBER 31, 2023
The effects of curcumin, EGCG (epigallocatechin gallate), genistein and resveratrol on four membrane proteins were reported in Ref9 and these effects would raise doubts about activity for any of these compounds (or their close structural analogs) that had been observed in a cell-based assay.
Expert insights. Personalized for you.
106 
Let's personalize your content