Sun.Apr 27, 2025

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Head Injuries Are a Growing Risk for Anesthesiologists, Experts Warn

Drugs.com

SUNDAY, April 27, 2025 One moment, Dr. Cornelius Sullivan was standing over a patient during surgery. The next, he woke up in an ambulance on the way to the emergency room.The anesthesiologist had hit his head on a monitor that had been moved b.

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Discovery and Optimization of a Covalent AKR1C3 Inhibitor

Covalent Modifiers

R. Justin Grams, Wesley J. Wolfe, Robert J. Seal, James Veccia, and Ku-Lung Hsu Journal of Medicinal Chemistry 2025 DOI: 10.1021/acs.jmedchem.5c00050 Aldo-keto reductase family 1 member C3 (AKR1C3) is a member of the AKR superfamily of enzymes that metabolize androgen, estrogen, and prostaglandin substrates that drive proliferation in hormone-dependent cancers.

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Don’t Forget to Register for HPM’s May 1 Webinar on Enforcement Under the New FDA!

FDA Law Blog: Biosimilars

By Hyman, Phelps & McNamara, P.C. As a reminder, Hyman, Phelps & McNamara, P.C. is hosting a free webinar on recent and forward-looking enforcement under the Federal Food, Drug & Cosmetic Act on Thursday, May 1, 2025, from 12:00 p.m. to 1:30 p.m. (ET). Registration is limited, so dont forget to register here to join us this Thursday. HPMs Anne Walsh will moderate a panel discussion with three former DOJ attorneys who all litigated extensively under the FDC Act.

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Trospium chloride

New Drug Approvals

Trospium chloride CAS 47608-32-2 10405-02-4 WeightAverage: 392.518 Monoisotopic: 392.22202025 Chemical FormulaC 25 H 30 NO 3 T4Y8ORK057 73954-17-3 8-Benziloyloxy-6,10-ethano-5-azoniaspiro(4.5)decane chloride 3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-8lambda5-azaspiro[bicyclo[3.2.1]octane-8,1′-pyrrolidin]-8-yliumchloride spiro[8-azoniabicyclo[3.2.1]octane-8,1′-azolidin-1-ium]-3-yl 2-hydroxy-2,2-diphenylacetate;chloride SMR002533165 spiro[8-azoniabicyclo[3.2.1]octane-8,1′-azolidin-1-

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Drug Channels News Roundup, April 2025: Amazon Rx Update, Express Scripts’ Spend Trends, Gold Cards, and CMS Acronym Absurdity

Drug Channels

Spring has officially arrived at Drug Channels' worldwide headquarters in beautiful downtown Philadelphia. (Photo proof at right.) So, scurry over to this months curated crop of noteworthy news: Amazon Pharmacy is still coming for retail pharmacy Express Scripts revives its long-lost drug trend report Prior authorization gold cards: Progress or peril?

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Is ABC Classification a thing of the past?

Perficient: Drug Development

When it comes to cycle counting, the first thing that comes to mind is ABC classifications of the items and then a cycle count program to count items throughout the year on a continuous basis. There is nothing wrong with the ABC classifications if the organization is mature enough with its items and the classification criteria is going to be somewhat stable during the year.

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