Sun.May 18, 2025

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Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of the mitophagy regulator USP30

Covalent Modifiers

Nafizul Haque Kazi, Nikolas Klink, Kai Gallant, Gian-Marvin Kipka & Malte Gersch Nat Struct Mol Biol , 2025 [link] The mitochondrial deubiquitinase ubiquitin-specific protease (USP) 30 negatively regulates PINK1parkin-driven mitophagy. Whether enhanced mitochondrial quality control through inhibition of USP30 can protect dopaminergic neurons is currently being explored in a clinical trial for Parkinsons disease.

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Gene Therapy Studies and Germline Integration Assessment in Nonhuman Primates

Alta Sciences

Gene Therapy Studies and Germline Integration Assessment in Nonhuman Primates iianiro Sun, 05/18/2025 - 09:00 Publication Poster_Altasciences_ASGCT_2025Gene Therapy Studies and Germline Integration Assessment in Nonhuman Primates.

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Got Pruney Fingers? Here's The Scientific Skinny To Explain It

Drugs.com

SUNDAY, May 18, 2025 As swimming season heats up, you might notice your fingers wrinkle after spending time in the water turns out, those wrinkles are the same with every dip you take.And that, researchers from Binghamton University, State Uni.

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Digadoglucitol

New Drug Approvals

Digadoglucitol DA-52534 CAS 2098944-37-5 -[2,2′,2”,2”’,2””,2””’-({[(2S,3R,4R,5R)-2,3,4,5,6- pentahydroxyhexyl]azanediyl}bis{[2-(hydroxy-O)propane3,1-diyl]-1,4,7,10-tetraazacyclododecane-10,1,4,7-tetrayl4 N1 ,N4 ,N7 ,N10})hexa(acetato-O)]digadolinium diagnostic agent C40H69Gd2N9O19 MW 1,294.536 F2Q2ZU6CAU Digadoglucitol free acid USL2PB6YFS 1-[Bis[2-hydroxy-3-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]propyl]amino]-1-deoxy-D-

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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It’s a Bird, It’s a Plane, It’s an UPDATE on Operation Stork Speed

FDA Law Blog: Biosimilars

By Charles D. Snow Operation Stork Speed is a go! On March 18, 2025, the U.S. Department of Health and Human Services (HHS) and the Food and Drug Administration (FDA) launched a significant initiative called Operation Stork Speed to bolster the availability and safety of infant formula in the United States (see our previous blog post here ). The March announcement outlined six key actions underlying Operation Stork Speed, including the launch of the first comprehensive review of infant formula

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