The Nature of Nanodisc Lipids Influences Fragment‐Based Drug Discovery Results
Chemical Biology and Drug Design
MARCH 14, 2025
Fragment-based drug discovery (FBDD) was applied to cytochrome P450 3A4 reconstituted in Nanodiscs (NDs) with various lipid compositions. The choice of ND lipid influenced drug membrane interactions and fragment hit rates, demonstrating the critical role of the membrane environment in fragment screening for membrane proteins.
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