Metabolic Stability Pharmacokinetics Research 
Chemical Biology and Drug Design
SEPTEMBER 20, 2023
Magnoflorine increased the systemic exposure and metabolic stability and suppressed the transport of luteolin. The pharmacokinetic study was performed on male Sprague–Dawley rats randomly grouped as the single administration of luteolin and the co-administration of luteolin and magnoflorine with six rats of each.
Chemical Biology and Drug Design
JUNE 8, 2023
The co-administration of cryptotanshinone with ophiopogonin D induced pharmacokinetic interaction prolonging the systemic exposure and improving metabolic stability of cryptotanshinone. Abstract Cryptotanshinone and ophiopogonin D are sourced from herbs with similar indications. to 8.58 ± 0.71 μg/mL μg/mL and from 15.99 ± 1.81
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DrugBank
OCTOBER 17, 2024
Computational chemistry and molecular modeling techniques can predict potential drug candidates' binding affinity and pharmacokinetic properties, enabling the selection of the most promising compounds for further development. These complex molecules require precise engineering to ensure optimal efficacy and safety.
Drug Target Review
JUNE 12, 2023
Leveraging AI-guided structure-based drug design, Insilico’s research and development team generated an impressive portfolio of over 6,000 molecules and identified three highly promising hit series. He is an adjunct professor of artificial intelligence at the Buck Institute for Research on Aging.
Metabolite Tales Blog
DECEMBER 13, 2023
To curb glucuronidation at that position a gem-dimethyl group was incorporated which not only boosted metabolic stability, but also resulted in increased potency of the final lead compound. 8(2):3640-3648; [link] [11] Pharmacokinetics of the Multi-kinase Inhibitor Pexidartinib: Mass Balance and Dose Proportionality. Oncotarget.
Molecular Design
MAY 11, 2019
The heavy citation and wide acceptance of Ro5 provided incentives for researchers to publish their own respective analyses of large (usually proprietary) data sets and this has been expressed more succinctly as “Ro5 envy”. So let's take a look at YL2018 and the trajectories.
Metabolite Tales Blog
MARCH 1, 2023
Bicyclic structures containing five membered rings such as indoles, consisting of a six-membered benzene ring fused to a five-membered pyrrole ring, are also increasingly relevant as growing research fields such as psychedelics make use of these scaffolds, often found in natural products. 2010, 75, 9, 3141–3143 [link] 22 Clin Pharmacokinet.
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