New Drug Approvals

JULY 18, 2025

22] In the same month, China’s drug regulator (NMPA) decided to fast-track the approval process, labelling it a first-in-class medication. [14] In July 2022, China’s drug regulator granted conditional approval for it to be used to treat COVID-19, following a local phase III trial. [6] April 2011). 81 (7): 848–855.

RNA

Drug Target Review

MARCH 12, 2024

Bile acids are crucial signalling molecules that aid the regulation of the immune system and have essential metabolic functions, like controlling lipid and glucose metabolism. Biochemical Pharmacology. Also, they help to explain how microbes in the gut can influence distant organ systems. Gut Microbes.

Disease

Drug Target Review

JUNE 6, 2023

This suppressive mechanism involves a negative regulator – a protein called IL-18BP or IL-18 binding protein, that works as a “decoy receptor” by binding to IL-18 and preventing it from binding to its functional receptor. Clinical development of IL-18 therapies has been curtailed, however, by the protein’s lack of efficacy.

Engineering