Broad Institute

MAY 21, 2025

In the 1990s, Michel Sadelain then at Memorial Sloan Kettering Cancer Center (MSKCC) designed CARs by combining fragments of tumor-recognizing antibodies with the molecular machinery found in T-cell receptors. That ability to stick around, which is critical for attacking cancer over time, was another turning point.

Therapies 119

Therapies FDA Approval Engineering Immune Response 119

Codon

APRIL 30, 2023

Also, last week’s digest had an error: The country that approved the malaria vaccine was Ghana. 🔥 Five Amazing Things (That happened this week…) 1/ CRISPR Protein Penetrates Cells Not one, but two new papers report a better way to deliver Cas9 or Cas12 gene-editing proteins into living cells. Things are good.

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

APRIL 30, 2023

Also, last week’s digest had an error: The country that approved the malaria vaccine was Ghana. 🔥 Five Amazing Things (That happened this week…) 1/ CRISPR Protein Penetrates Cells Not one, but two new papers report a better way to deliver Cas9 or Cas12 gene-editing proteins into living cells. Things are good.

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

APRIL 9, 2023

Read Efficacy and safety of a bivalent RSV prefusion F vaccine in older adults. Read Rational design of a highly immunogenic prefusion-stabilized F glycoprotein antigen for a respiratory syncytial virus vaccine. npj Vaccines. Nature Cell Biology. Video explaining mRNA vaccines (h/t Morgan Cheatham ).

Therapies 52

Therapies RNA Engineering Vaccine 52

Codon

APRIL 16, 2023

This looks like an early step toward a much different future for biology: One in which natural language is used to design experiments, program robots, and automate experiments in high-throughput. Skin microbes can trigger strong immune responses. epidermidis , can actually trigger tumor-specific T cells. Cell Reports.

Engineering 52

Engineering DNA RNA Science 52