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Danyang Hu, Hairong Zeng, Wenxuan Li, Ya Zhang, Xiaoqian Chi, Xiaoyu Liu, Haijing Zhang, Guangbo Ge, Xiaozhen Jiao, and Ping Xie Journal of Medicinal Chemistry 2025 DOI: 10.1021/acs.jmedchem.5c00563 Mammalian carboxylesterases play an important role in the hydrolysis of both endogenous substrates and xenobiotics bearing ester or amide bond(s). We previously reported that bysspectin A and its derivative LC-20W were potent reversible hCES2A inhibitors.
In the ever-evolving landscape of immuno-oncology, managing the side effects of advanced therapies has become just as important as enhancing their efficacy. Among the most concerning complications is cytokine release syndrome (CRS), a potentially life-threatening condition that frequently follows the administration of some CAR T-cell therapies and bispecific antibodies.
FRIDAY, May 23, 2025 A new White House report says todays children are the sickest generation in U.S. history when it comes to chronic disease, and it puts the blame on environmental toxins, poor nutrition and too much screen time.Called the "MA.
In the evolving landscape of cancer research, the development and validation of effective therapeutic agents depend heavily on preclinical models that can replicate human disease with high fidelity. Among these, syngeneic models have emerged as a vital tool in oncology research, offering a unique balance between experimental control and biological relevance.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
A group of fossils of elasmosaurs -- some of the most famous in North America -- have just been formally identified as belonging to a 'very odd' new genus of the sea monster, unlike any previously known. This primitive 85-million-year-old, 12 meter-long, fiercely predatory marine reptile is unlike any elasmosaur known to-date and hunted its prey from above.
By Allyson B. Mullen & Jennifer D. Newberger Last week, FDA published a Request for Information (RFI) ( here ) seeking input from the public on its efforts to to identify and eliminate outdated or unnecessary regulations. The Announcement raises several questions and issues for the device industry. 10-for-1 Rule and its effect on de novos. The RFI reinforces Trumps January 31, 2025 executive order indicating that for every new regulation introduced, at least ten existing regulations must be
Cold-adapted animals started to evolve 2.6 million years ago when the permanent ice at the poles became more prevalent. There followed a time when the continental ice sheets expanded and contracted and around 700,000 years ago the cold periods doubled in length. This is when many of the current cold-adapted species, as well as extinct ones like mammoths, evolved.
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Cold-adapted animals started to evolve 2.6 million years ago when the permanent ice at the poles became more prevalent. There followed a time when the continental ice sheets expanded and contracted and around 700,000 years ago the cold periods doubled in length. This is when many of the current cold-adapted species, as well as extinct ones like mammoths, evolved.
As the patents for blockbuster biologics expire, a new era of opportunity emerges, ushering in the rise of biosimilars. These biologic alternatives offer the promise of affordable care, broader global […] The post Open New Markets: How Biosimilar Clinical Trials Drive Access, Profitability, and Global Expansion … appeared first on ProRelix Research.
Scientists create a floss pick that samples cortisol within saliva as a marker of stress and quantifies it with a built-in electrode. The system uses a polymer casting technology that can be adapted to capture a wide a range of markers, such as estrogen for tracking fertility, or glucose for tracking diabetes. Ease of use allows monitoring to be incorporated into many areas of treatment.
Radiopharmaceuticals are transforming modern medicine,while simultaneously intensifying the pressures on pharmaceutical supply chains. | Radiopharma is revolutionizing modern medicine. Discover how precision logistics empowers faster, safer delivery of life-impacting therapies when every second counts.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
FRIDAY, May 23, 2025 A federal deadline ending sale of off-brand weight-loss and diabetes medications is now in effect, cutting off access to drugs many patients count on.The U.S. Food and Drug Administration (FDA) already declared that shortages.
Researchers united insights from cellular biology, quantum computing, old-fashioned semiconductors and high-definition TVs to both create a revolutionary new quantum biosensor. In doing so, they shed light on a longstanding mystery in quantum materials.
FRIDAY, May 23, 2025 -- The U.S. Food and Drug Administration has approved Nucala (mepolizumab) as an add-on maintenance treatment for adult patients with inadequately controlled chronic obstructive pulmonary disease (COPD).Nucala stands out as the.
A new experiment encodes quantum information in the motion of the atoms and creates a state known as hyper-entanglement, in which two or more traits are linked among a pair of atoms.
Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
FRIDAY, May 23, 2025 Women are 10 times more likely to develop postpartum psychosis if they have a sister who experienced the condition after an earlier pregnancy, a new study says.Postpartum psychosis is a rare but serious mental illness that c.
FRIDAY, May 23, 2025 Pod-style e-cigarettes appear to be more addictive than nicotine gum, making it harder for vapers to kick the habit, a small-scale lab study has found.E-cigarettes reinforced nicotine addiction more than nicotine gum among y.
As sea levels climb and weather grows more extreme, coastal regions everywhere are facing a creeping threat: salt. Salinization of freshwater and soils adversely affects 500 million people around the world, especially in low-lying river deltas. A new study sheds light on how rising oceans are pushing saltwater into freshwater rivers and underground water sources in the world's largest river mouth -- the Bengal Delta in Bangladesh.
Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
FRIDAY, May 23, 2025 -- Eczema sufferers could soon find it easier to track their skin condition, via a newly developed AI that can assess severity using uploaded smartphone images.The AI demonstrated high diagnostic accuracy in evaluating eczema.
FRIDAY, May 23, 2025 Dirty, crowded urban environments can significantly increase a persons risk of developing asthma, a new study says.Cleaner, better-thought-out cities could ward off 1 of every 10 asthma cases, researchers reported recently in.
Scientists may have solved the mystery of why the moon shows ancient signs of magnetism although it has no magnetic field today. An impact, such as from a large asteroid, could have generated a cloud of ionized particles that briefly enveloped the moon and amplified its weak magnetic field.
Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
The natural compounds berberine, cryptopine, phillygenin, and dimethylmatairesinol exhibit notable antioxidant and anti-inflammatory properties, closely associated with the 3,4-dimethoxybenzene structure within them. By leveraging the molecular hybridization principle based on the scaffold of fibrate lipid-lowering drugs, we have designed fibrate derivatives centered on 3,4-dimethoxybenzene.
The synthetic peptides WK-MAP1 and WG-MAP2, bioinspired by papain, demonstrated optimized activity, particularly against multidrug-resistant Klebsiella pneumoniae , with improved sequence interaction profiles, membrane affinity, and predicted antimicrobial and antibiofilm efficacy, supporting their potential as therapeutic peptide candidates. ABSTRACT Bacterial resistance represents one of the greatest challenges in modern medicine, requiring innovative strategies.
Durlobactam CAS 1467829-71-5 WeightAverage: 277.25 Monoisotopic: 277.03685626 Chemical FormulaC 8 H 11 N 3 O 6 S Ingredient UNII CAS InChI Key Durlobactam sodium F78MDZ9CW9 1467157-21-6 WHHNOICWPZIYKI-IBTYICNHSA-M FDA 5/23/2023, Xacduro , To treat hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia caused by susceptible isolates of Acinetobacter baumannii-calcoaceticus complex Press Release Drug Trials Snapshots (2S,5R)-2-CARBAMOYL-3-METHYL-7-OXO-1,6-DIAZABICYCLO(
In todays world, there are various data formats such as traditional, unstructured, raw format and semi structured data and load into target system. Semi structured data is often used in web applications, IOT and API sensors. Customers use JSON format mostly to get the data because it is easy to understand. Snowflake Snowflake is a cloud data warehouse that helps to load different data types and format of data.
Overactive bladder (OAB) is a chronic and disabling condition that affects millions of people worldwide, significantly impacting physical, psychological, and social well-being. An estimated 183 million people worldwide suffer from overactive bladder, highlighting its global prevalence. 1 While OAB is more common in older adults, it can also affect younger individuals.
FRIDAY, May 23, 2025 Seniors who stay socially engaged are much more likely to have longer lives, a new study says.Social engagement among seniors is associated with a lower risk of death, when compared to seniors who are loners, according to f.
FRIDAY, May 23, 2025 Alcohol-fueled cancer deaths nearly doubled in the United States during the past three decades, with cases among men driving this surge, a new study says.Between 1990 and 2021, deaths from alcohol-related cancers leaped from j.
FRIDAY, May 23, 2025 Former President Joe Biden's prostate cancer diagnosis has drawn attention to screening guidelines for older men. When Biden, 82, was diagnosed last week, his cancer had already spread to his bones. His last prostate s.
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