Fri.Jul 05, 2024

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Drug’s unique mechanism of action targets schizophrenia abnormalities

Drug Discovery World

Newron Pharmaceuticals has reported new findings of mechanism of action that indicate its drug candidate evenamide could be uniquely effective in patients with treatment resistant schizophrenia (TRS). The drug’s unique mechanism of action targets the core abnormalities in patients with schizophrenia and reduces hippocampal dopaminergic activity, improving symptoms of psychosis, social interactions and cognition.

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A hybrid evaluation of the intestinal absorption performance of compounds from molecular structure

Chemical Biology and Drug Design

The QSPR model accurately predicted the intestinal absorption of molecules, and the computer simulation found the mechanism of molecular structure affecting intestinal absorption. Abstract Intestinal absorption of compounds is significant in drug research and development. To evaluate this efficiently, a method combining mathematical modeling and molecular simulation was proposed, from the perspective of molecular structure.

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New Scandinavian ALS drug research collaboration

Drug Discovery World

The Division of Clinical Neuroscience at Oslo University Hospital (OUS) and the Swedish drug development company TikoMed have signed a research collaboration agreement focused on amyotrophic lateral sclerosis (ALS). TikoMed has previously completed and reported on two successful Phase IIa clinical studies in ALS, one at the Sahlgrenska University Hospital in Sweden and one at the University of Birmingham in the UK, both with promising results.

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The Effects the ICH E6(R3) Updates Will Have on Good Clinical Practice

Quanticate

Good Clinical Practice (GCP) affects a variety of entities, including sponsors, contract research organisations (CROs), and investigator sites. It’s essential for maintaining ethical standards, high-quality outcomes and facilitating global standardisation, enabling multi-center and multinational studies, thereby streamlining the development and approval process for new medical treatments, and maintaining public trust in clinical research.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Gene therapy trial starts in early-onset dementia

Drug Discovery World

AviadoBio has launched its Phase I/II ASPIRE-FTD clinical trial at the Ohio State University in the US. ASPIRE-FTD is evaluating investigational gene therapy AVB-101 in people with frontotemporal dementia (FTD) with progranulin (GRN) gene mutations (FTD-GRN). The study is also recruiting in Europe with study sites in the Netherlands, Poland, and Spain, with additional sites expected to open in multiple countries.

Therapies 147
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Heart Experts Have Tips on Staying Safe in the Summer Heat

Drugs.com

FRIDAY, July 5, 2024 -- As Americans brace themselves for another summer of brutal heat and humidity, the American Heart Association (AHA) warns that heart patients need to take extra precautions to protect themselves.According to the U.S. Centers.

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Survey Shows Men Need to Do More to Prevent Cancer

Drugs.com

FRIDAY, July 5, 2024 -- American men are blowing their best chance to head off cancer or spot it early, when it's easiest to treat, a new survey warns.More than 6 in 10 (65%) men in the nationwide survey said they are behind on at least one routine.

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Fresh wind blows from historical supernova

Science Daily: Pharmacology News

A mysterious remnant from a rare type of supernova recorded in 1181 has been explained for the first time. Two white dwarf stars collided, creating a temporary 'guest star,' now labeled supernova (SN) 1181, which was recorded in historical documents in Japan and elsewhere in Asia. However, after the star dimmed, its location and structure remained a mystery until a team pinpointed its location in 2021.

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Federal WIC Program May Boost Pregnancy Outcomes for Women, Newborns

Drugs.com

FRIDAY, July 5, 2024 -- Pregnant women enrolled in a federal aid program have better outcomes than those who are struggling to put food on the table, new research shows.More than 1 in 10 households nationwide lack access to adequate and nutritious.

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Recruitment of FBXO22 for targeted degradation of NSD2 [@CherylArrowsmi1]

Covalent Modifiers

Nie, D.Y., Tabor, J.R., Li, J. et al. Nat Chem Biol (2024). [link] Targeted protein degradation (TPD) is an emerging therapeutic strategy that would benefit from new chemical entities with which to recruit a wider variety of ubiquitin E3 ligases to target proteins for proteasomal degradation. Here we describe a TPD strategy involving the recruitment of FBXO22 to induce degradation of the histone methyltransferase and oncogene NSD2.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Brain organoids: a fascinating and powerful tool for drug discovery

Drug Target Review

Building three-dimensional models in the lab Brain organoids are three-dimensional (3D) multicellular structures derived from the differentiation of human pluripotent stem cells (hPSCs), including induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs), under specific in vitro neuronal induction conditions, using specific support matrices.

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New tentative approval for Alembic drug dabigatran etexilate mesylate

Drug Patent Watch

Dabigatran etexilate mesylate is the generic ingredient in two branded drugs marketed by Alkem Labs Ltd, Apotex, Hetero Labs Ltd Iii, and Boehringer Ingelheim and, and is included in five NDAs.

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Revolutionizing OpenAI Chatbot UI Deployment with DevSecOps

Perficient: Drug Development

In the contemporary era of digital platforms, capturing and maintaining user interest stands as a pivotal element determining the triumph of any software. Whether it’s websites or mobile applications, delivering engaging and tailored encounters to users holds utmost significance. In this project, we aim to implement DevSecOps for deploying an OpenAI Chatbot UI, leveraging Kubernetes (EKS) for container orchestration, Jenkins for Continuous Integration/Continuous Deployment (CI/CD), and Doc

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New patent expiration for Abbvie drug ORILISSA

Drug Patent Watch

Annual Drug Patent Expirations for ORILISSA Orilissa is a drug marketed by Abbvie and is included in one NDA. It is available from one supplier. There are ten patents protecting this drug.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Meet the Expert: Terri Levine

thought leadership

Our “Meet the Expert” series introduces you to our team of experts around the world. This “behind the curtain” view will help you get to know who we are on a professional and personal level, and highlight how our colleagues work together on our higher purpose to improve patient health and safety throughout the complete product lifecycle.

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New patent for Medicines360 drug LILETTA

Drug Patent Watch

Annual Drug Patent Expirations for LILETTA Liletta is a drug marketed by Medicines360 and is included in one NDA. It is available from one supplier. There are three patents protecting this drug.

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This week in drug discovery (1-5 July) 

Drug Discovery World

News round-up for 1-5 July by DDW Senior Digital Content Editor Diana Spencer. The last few days have seen some interesting developments related to gene editing, including the discovery of a new mechanism for genetic programming and evidence in favour of redosing CRISPR-based therapies, as well as significant investment and new indications for gene therapies.

Therapies 147
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New patent for Deciphera Pharms drug QINLOCK

Drug Patent Watch

Annual Drug Patent Expirations for QINLOCK Qinlock is a drug marketed by Deciphera Pharms and is included in one NDA. It is available from one supplier.

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Which pharmaceutical drugs have the most drug patents in Denmark?

Drug Patent Watch

This chart shows the drugs with the most patents in Denmark. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is desired.