Chemical Biology and Drug Design

JULY 5, 2024

The QSPR model accurately predicted the intestinal absorption of molecules, and the computer simulation found the mechanism of molecular structure affecting intestinal absorption. Abstract Intestinal absorption of compounds is significant in drug research and development. To evaluate this efficiently, a method combining mathematical modeling and molecular simulation was proposed, from the perspective of molecular structure.

Drug Research 100

Drug Research Research Drugs 100

Quanticate

JULY 5, 2024

Good Clinical Practice (GCP) affects a variety of entities, including sponsors, contract research organisations (CROs), and investigator sites. It’s essential for maintaining ethical standards, high-quality outcomes and facilitating global standardisation, enabling multi-center and multinational studies, thereby streamlining the development and approval process for new medical treatments, and maintaining public trust in clinical research.

Drug Development 109

Drug Development Clinical Research Treatment Research 109

Drugs.com

JULY 5, 2024

FRIDAY, July 5, 2024 -- As Americans brace themselves for another summer of brutal heat and humidity, the American Heart Association (AHA) warns that heart patients need to take extra precautions to protect themselves.According to the U.S. Centers.

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Science Daily: Pharmacology News

JULY 5, 2024

A mysterious remnant from a rare type of supernova recorded in 1181 has been explained for the first time. Two white dwarf stars collided, creating a temporary 'guest star,' now labeled supernova (SN) 1181, which was recorded in historical documents in Japan and elsewhere in Asia. However, after the star dimmed, its location and structure remained a mystery until a team pinpointed its location in 2021.

Research 94

Research 94

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drugs.com

JULY 5, 2024

FRIDAY, July 5, 2024 -- American men are blowing their best chance to head off cancer or spot it early, when it's easiest to treat, a new survey warns.More than 6 in 10 (65%) men in the nationwide survey said they are behind on at least one routine.

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Covalent Modifiers

JULY 5, 2024

Nie, D.Y., Tabor, J.R., Li, J. et al. Nat Chem Biol (2024). [link] Targeted protein degradation (TPD) is an emerging therapeutic strategy that would benefit from new chemical entities with which to recruit a wider variety of ubiquitin E3 ligases to target proteins for proteasomal degradation. Here we describe a TPD strategy involving the recruitment of FBXO22 to induce degradation of the histone methyltransferase and oncogene NSD2.

Targeted Protein Degradation 80

Targeted Protein Degradation Disease Drugs 80

Drug Target Review

JULY 5, 2024

Building three-dimensional models in the lab Brain organoids are three-dimensional (3D) multicellular structures derived from the differentiation of human pluripotent stem cells (hPSCs), including induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs), under specific in vitro neuronal induction conditions, using specific support matrices.

Targeted Protein Degradation 65

Targeted Protein Degradation Drugs Disease FDA Approval 65

Drug Patent Watch

JULY 5, 2024

Dabigatran etexilate mesylate is the generic ingredient in two branded drugs marketed by Alkem Labs Ltd, Apotex, Hetero Labs Ltd Iii, and Boehringer Ingelheim and, and is included in five NDAs.

Drugs 59

Drugs Marketing 59

Perficient: Drug Development

JULY 5, 2024

In the contemporary era of digital platforms, capturing and maintaining user interest stands as a pivotal element determining the triumph of any software. Whether it’s websites or mobile applications, delivering engaging and tailored encounters to users holds utmost significance. In this project, we aim to implement DevSecOps for deploying an OpenAI Chatbot UI, leveraging Kubernetes (EKS) for container orchestration, Jenkins for Continuous Integration/Continuous Deployment (CI/CD), and Doc

Compliance 52

Compliance Regulations Production 52

Drug Patent Watch

JULY 5, 2024

Annual Drug Patent Expirations for ORILISSA Orilissa is a drug marketed by Abbvie and is included in one NDA. It is available from one supplier. There are ten patents protecting this drug.

Drugs 59

Drugs Marketing 59

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

thought leadership

JULY 5, 2024

Our “Meet the Expert” series introduces you to our team of experts around the world. This “behind the curtain” view will help you get to know who we are on a professional and personal level, and highlight how our colleagues work together on our higher purpose to improve patient health and safety throughout the complete product lifecycle.

Production 52

Production Clinical Research Research 52

Drug Patent Watch

JULY 5, 2024

Annual Drug Patent Expirations for LILETTA Liletta is a drug marketed by Medicines360 and is included in one NDA. It is available from one supplier. There are three patents protecting this drug.

Drugs 59

Drugs Marketing 59

Drug Patent Watch

JULY 5, 2024

Annual Drug Patent Expirations for QINLOCK Qinlock is a drug marketed by Deciphera Pharms and is included in one NDA. It is available from one supplier.

Drugs 59

Drugs Marketing 59

Drug Patent Watch

JULY 5, 2024

This chart shows the drugs with the most patents in Denmark. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is desired.

Pharmaceuticals 59

Pharmaceuticals Drugs 59

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials