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Therapeutic Oligos 2025 Keynote Speakers Announced

Elrig

Prof Rory Johnson is an Associate Professor at University College Dublin, where his research focusses on uncovering the roles of long noncoding RNAs (lncRNAs) in human health and disease using an interdisciplinary combination of bioinformatic and experimental methods.

RNA 59
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Biochemical assays and deep cyclic inhibition in cancer treatment

Drug Target Review

Omics data, including pharmacogenomics data from 3D-TGAs, provide us with unique information about the molecular mechanisms of disease biology and drug response. Importantly, transcriptomics information shows that certain aspects of a disease change the gene expression profile.

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AI in Drug Discovery - A Highly Opinionated Literature Review (Part II)

Practical Cheminformatics

GPT-4 could provide the sequence and binding sites for the SARS-CoV-2 main protease, but this information can also be readily accessed through the PDB. The responses seemed more like a “ stochastic parrot ” that could grab information and key phrases from online documents. First, summarization and information retrieval.

Drugs 136
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Accelerating Drug Discovery Through Repurposing

DrugBank

This approach capitalizes on prior investments in R&D, mitigates risk by leveraging established safety and pharmacokinetic profiles, and accelerates the delivery of treatments to patients. In Silico Drug Repurposing Advances in bioinformatics and systems biology have fueled the rise of repurposing of in silico drugs.

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Amgen To Acquire Privately Held Teneobio For $900 Million In Cash With Future Contingent Milestone Payments

The Pharma Data

. “Over the last five years, Teneobio developed leading-edge expertise in efficiently engineering differentiated multispecific and bispecific therapeutics for numerous indications with potentially better safety, efficacy and pharmacokinetic profiles than the first generation of T-cell engagers. ” In June 2021, AbbVie Inc.

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United Therapeutics Corporation Reports Third Quarter 2020 Financial Results

The Pharma Data

Medtronic continues to work toward satisfying these conditions, but in December 2019 , due to FDA communications, Medtronic informed us that these conditions will not be satisfied in 2020. In October 2020 , we completed a second clinical study in healthy volunteers to compare the pharmacokinetics of Treprostinil Technosphere to Tyvaso.

FDA 40
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Bristol Myers Squibb Announces Interim Results from Long-Term Study Reinforcing Efficacy and Safety Profile of Zeposia (ozanimod) in Patients with Relapsing Forms of Multiple Sclerosis

The Pharma Data

Inhibition of drug transporter breast cancer resistance protein has no effect on the pharmacokinetics of major active metabolites of ozanimod. Presentation Topic: Biomarkers and Bioinformatics. IMPORTANT SAFETY INFORMATION. For additional safety information, please see the full. Prescribing Information.