Sygnature Discovery

JUNE 17, 2024

Comprehensive Assay Development for Diverse Applications Our team here at Sygnature Discovery, comprised of expert biophysicists, is highly experienced in a variety of target classes and drug modalities. Sygnature Discovery’s Biophysical Assay Development Capabilities: 1. SPR is likely the best technique. MST may be for you.

Biophysical Assays 52

Biophysical Assays Screening Hits Assay Development Fragment Screening 52

Drug Target Review

NOVEMBER 1, 2023

With a structural technique such as X-ray crystallography we provide pictures of our inhibitors bound to their protein targets to help inform our computational and medicinal chemists in the design of improved inhibitors which is an iterative and very creative process.

Fragment Screening 96

Fragment Screening Biochemical Assays Small Molecule Biophysical Assays 96

Molecular Design

SEPTEMBER 18, 2024

I’ve discussed limitations of correlation-based metrics for assessment compatibility of assays in the preceding paragraph. I generally advise against binning continuous data prior to assessment of correlations because the operation discards information and the values of the correlation metrics vary with the scheme used to bin the data.]

Biochemical Assays 68

Biochemical Assays Drugs Biophysical Assays Cell Based Assays 68

Drug Target Review

JANUARY 16, 2025

18 Given the challenges around macrocycle flexibility, obtaining structural information on both macrocycles and target proteins is essential to understanding binding conformations and affinities. Additionally, this field is supported by industry trends towards a more multi- and interdisciplinary approach.

Drug Development 52

Drug Development Small Molecule Drugs FDA Approval 52