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Time for change: non-human primates in drug research

Drug Target Review

Their unique suitability has made them valuable for evaluating pharmacokinetics, toxicology and safety in drug candidates before human clinical trials. Guide for the Care and Use of Laboratory Animals. NIH Office of Laboratory Animal Welfare – Training Guidelines. Alternatives to Laboratory Animals , 50(3).

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New molecular insights on medical cannabis

Drug Target Review

2,8-10 However, the number of compounds with satisfying pharmacokinetic parameters (PKD) are limited, with most unable to cross the blood-brain barrier or go sufficiently deep into a malignant tumour. Recently, our laboratory discovered a potent partial inhibition of ATX by cannabinoids in a nanomolar range. 2002 Jul 22;158(2):227–33.

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Advanced 3D cell-based technologies

Drug Target Review

Some of the complex 3D models such as organoids and organ-on-chips have brought in realistic make-over to the drug screening and paved way into implementing high content screening, laboratory automation and miniaturisation in primary drug screening process. From 3D cell culture to organs-on-chips. Trends in Cell Biology.

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Codon Digest: Injected Gene Editors

Codon

A giant dataset about the rat brain, and how neurons connect to each other, was collected and pooled together from 20 different research laboratories. An open-source FACS automation system for high-throughput cell biology. “Human cells hacked to act like squid skin cells could unlock key to camouflage.”

DNA 52