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The experience showed me that new therapies are needed not only to meet the targets laid out by the End TB Strategy but also to prevent drug resistance from negating the effectiveness of current therapeutics. Some fluoroquinolones — a class of antibiotics that inhibits DNA replication — may even cause psychosis.
The newest FDA-approved gene therapy treats the severe, skin-peeling condition dystrophic epidermolysis bullosa (DEB). The gene treatment has been a long time coming, but it differs from the handful of other approved gene therapies: it isn’t a one-and-done. DEB has been a candidate for a gene therapy since 2002.
Advances in gene editing, personalised medicine, and regenerative therapies are improving patient outcomes and changing the landscape of healthcare. I visited several clinics that we supported through this programme around the US, observing the impact holistic, community-focused care can have on the people who need it most.
1 Many times, melanoma is caused by damage to the DNA in skin cells. 1 This damage to the DNA (often called a gene mutation) can cause cancerous tumors to form in the skin. 3 After surgery, patients may receive additional treatments to help lower the risk of the cancer returning, such as targeted therapies.
Archaeologists have found evidence of ancient Egyptian mummies carrying the pathogen’s DNA , including some that had developed Pott’s disease — a bending of the spine brought on by TB spreading to bones. This therapy didn’t have the desired outcome; his subjects quickly developed chills, fever, and vomiting.
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