Wed.Jun 12, 2024

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Are organoids superior to other preclinical models?

Drug Discovery World

Developing new drugs is a complex and often lengthy process. A major roadblock lies in the limitations of traditional preclinical models, which often fail to accurately represent the intricate biology of human patients. Join DDW for a free event on 18 June, 3PM BST to learn more about how patient-derived organoids are revolutionising drug discovery.

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AI-powered simulation training improves human performance in robotic exoskeletons

Science Daily: Pharmacology News

Researchers have demonstrated a new method that leverages artificial intelligence (AI) and computer simulations to train robotic exoskeletons to autonomously help users save energy while walking, running and climbing stairs.

Research 123
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Companies partner to identify biomarkers for renal cell carcinoma

Drug Discovery World

OncoHost and Dana-Farber Cancer Institute have launched a new study to identify biomarkers for renal cell carcinoma (RCC). Immune-checkpoint inhibitor (ICI) therapy has transformed treatment outcomes for RCC. However, ICIs can also trigger immune-related adverse events and may not benefit all patients. The collaboration will leverage Dana-Farber’s repository of patient plasma samples and corresponding clinical data, providing essential materials for OncoHost to create a proteomic plasma pr

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Swimming microrobots deliver cancer-fighting drugs to metastatic lung tumors in mice

Science Daily: Pharmacology News

Engineers have developed microscopic robots, known as microrobots, capable of swimming through the lungs to deliver cancer-fighting medication directly to metastatic tumors. This approach has shown promise in mice, where it inhibited the growth and spread of tumors that had metastasized to the lungs, thereby boosting survival rates compared to control treatments.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Avidity drug for muscular dystrophy shows promise; Syntis takes new approach to weight loss

BioPharma Drive: Drug Pricing

Study results indicated Avidity’s medicine muted target genes. Elsewhere, Syntis revealed obesity drug plans and Nodthera chalked up more positive data for its NLRP3 inhibitor.

Drugs 112
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OTC Hearing Aids: “Nothing to See Here” Says GAO Report

FDA Law Blog: Biosimilars

By Sara W. Koblitz & Jeffrey N. Gibbs — It’s been over a year and a half since Over-the-Counter (“OTC”) hearing aids became legal, and it’s not clear that they’ve made the difference in hearing loss treatment that Congress anticipated. (FDA once estimated that OTC hearing aids would save patients over $3000.) A recent GAO Report hasn’t found that OTC hearing aids have had much impact.

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Pfizer gene therapy for Duchenne fails to meet goals of key trial

BioPharma Drive: Drug Pricing

The negative results from the Phase 3 study, called Ciffreo, come a little more than a month after Pfizer said a patient died in another trial of the gene therapy.

Therapies 114
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Just thinking about a location activates mental maps in the brain

Science Daily: Pharmacology News

Researchers found that mental representations known as cognitive maps, located in the hippocampus and entorhinal cortex, are activated when the brain performs mental simulations of a navigational route.

Research 110
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Scientists Find Possible Antidote to Black Widow Spider Bite

Drugs.com

WEDNESDAY, June 12, 2024 -- A potential human-specific antidote to black widow spider venom has been discovered, researchers report.They have identified an antibody that effectively neutralizes black widow venom in lab tests of cell cultures.

Research 105
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Are plants intelligent? It depends on the definition

Science Daily: Pharmacology News

Goldenrod can perceive other plants nearby without ever touching them, by sensing far-red light ratios reflected off leaves. When goldenrod is eaten by herbivores, it adapts its response based on whether or not another plant is nearby. Is this kind of flexible, real-time, adaptive response a sign of intelligence in plants?

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Regenxbio CEO to step down after 15 years

BioPharma Drive: Drug Pricing

Kenneth Mills will become chair of the gene therapy developer's board while Curran Simpson, the current chief operating officer, will take his place as company head.

Therapies 104
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Towards a new era in flexible piezoelectric sensors for both humans and robots

Science Daily: Pharmacology News

Flexible piezoelectric sensors are essential to monitor the motions of both humans and humanoid robots. However, existing designs are either are costly or have limited sensitivity. In a recent study, researchers tackled these issues by developing a novel piezoelectric composite material made from electrospun polyvinylidene fluoride nanofibers combined with dopamine.

Research 108
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Up Close and Personal With Ashley (Schnider) Mahoney, Study Director, Scientist

Alta Sciences

Up Close and Personal With Ashley (Schnider) Mahoney, Study Director, Scientist nbartlett Wed, 06/12/2024 - 16:09 Ashley joined Altasciences in 2022 as Study Director. Along with managing non-GLP nonhuman primate (NHP) studies at our Sacramento, CA, site, Ashley coordinates study logistics with sponsors and internal departments, monitors study conduct, and maintains steady communication with sponsors.

Doctors 98
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What the geologic record reveals about how oceans were oxygenated 2.3 billion years ago

Science Daily: Pharmacology News

Geochemists used thallium isotopes to track the rise and fall of free oxygen on Earth between 2.5 and 2.2 billion years ago, the process that enabled life as we know it.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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More Sickened After Eating Diamond Shruumz Bars, Cones and Gummies

Drugs.com

WEDNESDAY, June 12, 2024 -- The number of people severely sickened after consuming mushroom edibles sold as Diamond Shruumz-brand Chocolate Bars, Cones or Gummies has risen, the U.S. Food and Drug Administration said Tuesday.As of Monday, "a total.

Drugs 98
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Western agricultural communities need water conservation strategies to adapt to future shortages

Science Daily: Pharmacology News

The Western U.S. is heavily reliant on mountain snowpacks and their gradual melt for water storage and supply, and climate change is expected to upend the reliability of this natural process. Many agricultural communities in this part of the country are examining ways to adapt to a future with less water, and new research shows that a focus on supplementing water supply by expanding reservoir capacity won't be enough to avert future water crises.

Research 106
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There's Another 'Magic' Mushroom Being Sold in Gummies -- But It Can Kill

Drugs.com

WEDNESDAY, June 12, 2024 -- Growing public fascination with “magic” psilocybin mushrooms as a trendy treatment for depression had led to increased interest in another type of psychedelic mushroom, a new study reports.Unfortunately, this second sort.

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Pacific coast gray whales have gotten 13% shorter in the past 20-30 years, Oregon State study finds

Science Daily: Pharmacology News

Gray whales that spend their summers feeding in the shallow waters off the Pacific Northwest coast have undergone a significant decline in body length since around the year 2000, a new study found.

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9/11 Responders May Face Higher Odds for Dementia

Drugs.com

WEDNESDAY, June 12, 2024 -- After helping America through one of its worst tragedies, some responders to the events of 9/11 may now face another foe: Heightened risks for dementia.A new study looks at the health of thousands of firemen.

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New technique reveals earliest signs of genetic mutations

Science Daily: Pharmacology News

Mutations are changes in the molecular 'letters' that make up the DNA code, the blueprint for all living cells. Some of these changes can have little effect, but others can lead to diseases, including cancer. Now, a new study introduces an original technique, called HiDEF-seq, that can accurately detect the early molecular changes in DNA code that precede mutations.

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Exercise at One Time of Day Might Be Best for Blood Sugar Control

Drugs.com

WEDNESDAY, June 11, 2024 -- Folks trying to control their blood sugar levels might do best to work out in the evening, a new study suggests.Exercise performed between 6 p.m. and midnight appeared to be better at controlling blood sugar levels all.

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Ritual sacrifice at Chichén Itzá

Science Daily: Pharmacology News

Rising to power in the wake of the Classic Maya collapse, Chich n Itz was among the largest and most influential cities of the ancient Maya, but much about its political connections and ritual life remain poorly understood. Close kin relationships, including two pairs of identical twins, suggests a connection to the Maya origin myths of the Popol Vuh.

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Dad Plays Role in His Infant's Microbiome

Drugs.com

WEDNESDAY, June 12, 2024 -- Dads appear to make a small but important contribution to a newborn baby’s gut health, a new study discovers.Many microbes found in babies throughout their first year of life originate in the father rather than the m.

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'Synthetic' cell shown to follow chemical directions and change shape, a vital biological function

Science Daily: Pharmacology News

In a feat aimed at understanding how cells move and creating new ways to shuttle drugs through the body, scientists say they have built a minimal synthetic cell that follows an external chemical cue and demonstrates a governing principle of biology called 'symmetry breaking.

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Biden Administration Pushes for Rule Wiping Medical Debt From Credit Reports

Drugs.com

WEDNESDAY, June 12, 2024 -- In an effort to keep medical debt from destroying credit scores, the Biden administration announced Tuesday that it is moving ahead with a proposal that would remove health care bills from consideration in credit.

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No bones about it: 100-million-year-old bones reveal new species of pterosaur

Science Daily: Pharmacology News

New research has identified 100-million-year-old fossilized bones discovered in western Queensland as belonging to a newly identified species of pterosaur, which was a formidable flying reptile that lived among the dinosaurs.

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Depression Could Take Toll on Memory With Age

Drugs.com

WEDNESDAY, June 12, 2024 -- Depression and memory declines may be closely linked in older people, new research suggests.“Our study shows that the relationship between depression and poor memory cuts both ways, with depressive symptoms preceding m.

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Soaring birds use their lungs to modify mechanics of flight

Science Daily: Pharmacology News

An air-filled sac within the birds' lungs is believed to increase the force the birds use to power flight muscles while soaring.

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Ultragenyx, Mereo drug reduces fractures in bone disorder study

BioPharma Drive: Drug Pricing

New data show the treatment’s effect on fractures and bone density held up over time, boosting the drug’s prospects ahead of a Phase 3 readout.

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Risk of secondary cancers after CAR-T cell therapy low, according to large study

Science Daily: Pharmacology News

In April, the FDA warned of risk of secondary cancers in people receiving CAR-T cell therapy. A large study now finds the risk is low and not related to the CAR-T cells.

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Foresite, a biotech venture firm, reloads with $900M fund

BioPharma Drive: Drug Pricing

Amid some optimism for biotech startups, the firm sees opportunities to fund companies “at all stages of the productive development life cycle,” said managing director Vik Bajaj.

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To heal skin, scientists invent living bioelectronics

Science Daily: Pharmacology News

Engineers have created a patch that combines sensors and bacteria to interact with the body.

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Flagship taps startup to hunt for obesity drugs that might interest Pfizer

BioPharma Drive: Drug Pricing

The venture firm will work with ProFound Therapeutics to “rapidly surface” protein drug candidates that Pfizer can choose to advance under a partnership it struck with Flagship last year.

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An AI-powered wearable system tracks the 3D movement of smart pills in the gut

Science Daily: Pharmacology News

Scientists have developed an artificial intelligence (AI)-powered system to track tiny devices that monitor markers of disease in the gut. Devices using the novel system may help at-risk individuals monitor their gastrointestinal (GI) tract health at home, without the need for invasive tests in hospital settings.