Tue.Apr 15, 2025

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The Ongoing Challenges of Understanding Long COVID and Exploring Innovative Solutions

Perficient: Drug Development

The COVID-19 pandemic has left an indelible mark on global health, with one of the most pressing concerns being the post-acute sequelae of SARS-CoV-2 infection, commonly referred to as “Long COVID” or Post-Acute Sequelae of SARS-CoV-2 (PASC). This complex and multifaceted condition has been a topic of intense research and debate in recent years, affecting millions of Americans and creating significant burdens on healthcare systems, workplaces, and families.

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AI finds new ways to observe the most extreme events in the universe

Science Daily: Pharmacology News

Extreme cosmic events such as colliding black holes or the explosions of stars can cause ripples in spacetime, so-called gravitational waves. Their discovery opened a new window into the universe. To observe them, ultra-precise detectors are required. Designing them remains a major scientific challenge for humans. Researchers have been working on how an artificial intelligence system could explore an unimaginably vast space of possible designs to find entirely new solutions.

Research 190
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⚡ PERFATHON 2025 – The First-Ever Hackathon at Perficient🚀

Perficient: Drug Development

April 1011, 2025, marked an exciting milestone for Perficient India as we hosted our very first hackathon Perfathon 2025. Held at our Bangalore office, this thrilling, high-energy event ran non-stop from 12 PM on April 10 to 4 PM on April 11, bringing together 6 enthusiastic teams, creative minds, and some truly impactful ideas. Setting the Stage The excitement wasnt just limited to the two days the buzz began a week in advance , with teasers and prep that got everyone curious and pumped.

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Molten Martian core could explain red planet's magnetic quirks

Science Daily: Pharmacology News

First ever supercomputer simulations of Mars with a fully molten core could explain the Red Planet's unusual magnetic field. Billions of years ago, Mars had an active magnetic field. Mysteriously, its imprint is strongest in the southern hemisphere. Researchers found that Mars could have produced a one-sided magnetic field with a fully molten core, rather than the traditional, Earth-like solid inner core setup.

Research 155
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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The Vital Role of Biomarkers in Neurodegenerative Pathways Early Phase Unit, Worldwide Clinical Trials

Conversations in Drug Development Trends

Early Phase Unit, Worldwide Clinical Trials Neurodegenerative diseases represent a diverse group of progressive disorders characterized by the loss of structure and function of neurons. Despite their clinical heterogeneity, these diseases often share overlapping pathological mechanisms, including protein misfolding and aggregation, synaptic dysfunction, neuroinflammation, and axonal degeneration.

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Studying how seals adapt to extreme environments could lead to benefits in human reproductive health

Science Daily: Pharmacology News

Wild animals that have acquired adaptions to maximize their reproductive output in some of the world's most extreme conditions may provide answers to some of the most pressing problems in the field of human reproductive health. A new journal article examines how the study of seals in particular can benefit human health, and synthesizes various research on the topic.

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More Trending

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An elegant method for the detection of single spins using photovoltage

Science Daily: Pharmacology News

Diamonds with certain optically active defects can be used as highly sensitive sensors or qubits for quantum computers, where the quantum information is stored in the electron spin state of these colour centeres. However, the spin states have to be read out optically, which is often experimentally complex. Now, a team has developed an elegant method using a photo voltage to detect the individual and local spin states of these defects.

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New Antibiotic, Blujepa, May Be Effective in Treating Gonorrhea

Drugs.com

TUESDAY, April 15, 2025 — A newly approved antibiotic to treat urinary tract infections may also help fight drug-resistant gonorrhea, a new study shows. The medication, called gepotidacin, sold under the brand name Blujepa, could become the.

Drugs 288
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Meat or veg? Plant-based protein is linked to a longer life, research shows

Science Daily: Pharmacology News

A global study has shown that countries which consume more plant-based proteins -- such as chickpeas, tofu and peas -- have longer adult life expectancies. Scientists studied food supply and demographic data between 1961-2018 from 101 countries, with the data corrected to account for population size and wealth, to understand whether the type of protein a population consumed had an impact on longevity.

Research 167
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New Antibiotic May Be Effective in Treating Gonorrhea

Drugs.com

TUESDAY, April 15, 2025 A newly approved antibiotic to treat urinary tract infections may also help fight drug-resistant gonorrhea, a new study shows.The medication, called gepotidacin, could become the first new gonorrhea treatment since the 1.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Making desalination more eco-friendly: New membranes could help eliminate brine waste

Science Daily: Pharmacology News

Desalination plants, a major and growing source of freshwater in dry regions, could produce less harmful waste using electricity and new membranes.

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Everyday Digital Tech Is Protecting Seniors' Brain Health, Study Says

Drugs.com

TUESDAY, April 15, 2025 -- Its a common notion that overuse of smartphones, tablets, laptops and other digital devices is rotting peoples minds.But the opposite appears to be true regular use of digital technology seems to protect the brain agai.

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Bristol Myers stumbles in bid to widen heart drug’s use

BioPharma Drive: Drug Pricing

Camzyos’ failure in a form of hypertrophic cardiomyopathy dampened its commercial outlook and spurred debate as to whether other drugs like it would similarly struggle in testing.

Drugs 164
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Smart Shirt Might Predict Heart Problems

Drugs.com

TUESDAY, April 15, 2025 -- A smart shirt equipped with an electrocardiogram (ECG) can help identify folks who are at higher risk of heart disease, a new study says.The shirt monitors peoples heart rate recovery after exercise, tracking the time i.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Mysterious atmosphere of 'Rosetta Stone' exoplanet

Science Daily: Pharmacology News

A new study modeled the chemistry of TOI-270 d, an exoplanet between Earth and Neptune in size, finding evidence that it could be a giant rocky planet shrouded in a thick, hot atmosphere. TOI-270 d is only 73 light years from Earth and could serve as a 'Rosetta Stone' for understanding an entire class of new planets.

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Miscommunication Between Health Workers Puts Patients At Risk Regularly

Drugs.com

TUESDAY, April 15, 2025 -- Miscommunication between hospital staff regularly puts patients at risk, a new study says.Poor communications between health care workers contributed to 25% of hospital incidents that put patients safety at risk, r.

Hospitals 225
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Health department layoffs may be illegal, experts say

BioPharma Drive: Drug Pricing

HHS bypassed normal procedures as it laid off thousands of employees, according to sources. One union has already filed an internal complaint, while at least two law firms are exploring suits.

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Pig Kidney Removed After Historic Transplant in Alabama Woman

Drugs.com

TUESDAY, April 15, 2025 Doctors have removed a genetically modified pig's kidney from an Alabama woman after her body rejected the organ, NYU Langone Health reported.Towana Looney, 53, had the transplanted organ for 130 days the longest anyone h.

Doctors 219
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Seismologists share early analyses of Myanmar earthquake

Science Daily: Pharmacology News

The 28 March magnitude 7.7 Mandalay, Burma (Myanmar) earthquake caused widespread and severe damage in Myanmar and neighboring countries such as Thailand, with more than 5,000 casualties now confirmed. At the Seismological Society of America's Annual Meeting, researchers from around the globe shared early insights into the earthquake's fault properties, ground shaking and infrastructure damage.

Research 149
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FDA Approves Combo of Opdivo Plus Yervoy for Advanced Liver Cancer

Drugs.com

TUESDAY, April 15, 2025 -- The U.S. Food and Drug Administration has approved Opdivo (nivolumab) plus Yervoy (ipilimumab) as a first-line treatment for adults with unresectable or metastatic hepatocellular carcinoma (HCC).The CheckMate-9DW.

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J&J keeps forecasts steady as pharma confronts tariff threat

BioPharma Drive: Drug Pricing

While J&J expects tariffs will cost it $400 million this year, the company maintained its earnings estimate and upped its sales guidance for 2025.

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In-Hospital Addiction Consultations Put Opioid Users On Path To Recovery

Drugs.com

TUESDAY, April 15, 2025 -- People hospitalized for opioid use can better fight their addiction if their path to recovery begins in the hospital, a new study says.Opioid users who receive addiction consultation services during their hospital stay.

Hospitals 179
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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The impact of biosimilars on biologic drug reimbursement models

Drug Patent Watch

"BREAKING: The $100 Billion Question - Can Biosimilars Disrupt the Status Quo in Biologic Drug Reimbursement Models? As the biologic market continues to grow, the impact of biosimilars on reimbursement models is becoming increasingly clear. With the average price of a biologic medication reaching upwards of $100,000 per year, the stakes are high.

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Pfizer Ends Testing of Obesity Pill, Danuglipron, After Possible Liver Injury

Drugs.com

TUESDAY, April 15, 2025 — Pfizer has stopped developing a once-daily pill to treat obesity after a person in a clinical trial showed signs of a possible liver injury. The company said the injury went away after the person stopped taking the.

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Understanding CDISC Standards in Clinical Research: A Complete Guide

Quanticate

The Clinical Data Interchange Standards Consortium (CDISC) establishes globally recognised standards that ensure data accuracy, consistency, and compliance in clinical research. As the globally accepted framework for structuring clinical trial data, CDISC enables seamless collaboration between sponsors, CROs, technology vendors, and global regulatory bodies such as the FDA, EMA, and PMDA.

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Gun Violence Leads To Skipped Dental Visits, Lost Teeth

Drugs.com

TUESDAY, April 15, 2025 -- Gun violence is bad for dental health, a new study says.More specifically, people are less likely to go to the dentist in neighborhoods with higher levels of firearm violence, researchers report in the American Journal of.

Research 165
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Analytical Method Development and Validation: Cost-Effective Approaches for Generic Drug Testing

Drug Patent Watch

"Breaking the Bank on Generic Drug Testing? Did you know that Analytical Method Development and Validation can account for up to 70% of the total cost of generic drug testing? At DrugPatentWatch, we've cracked the code on cost-effective approaches to speed up your generic drug testing process without sacrificing quality.

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ERs Treat A Gunshot Wound Every Half-Hour

Drugs.com

TUESDAY, April 15, 2025 -- U.S. emergency room doctors treat a gunshot wound every half-hour, a new study has found.Whats more, firearm injuries appear to follow specific patterns throughout the year, with gun violence occurring more often at c.

Doctors 147
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On Jupiter, it's mushballs all the way down

Science Daily: Pharmacology News

Observations of Jupiter show that ammonia is unevenly distributed in the upper atmosphere, against expectations of uniform mixing. Scientists found evidence for a complicated but apparently real process associated with fierce lightning storms: strong updrafts generate slushy, ice-coated hailstones of ammonia and water that eventually plunge into the planet and deplete areas of ammonia.

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Pfizer Ends Testing of Obesity Pill After Possible Liver Injury

Drugs.com

TUESDAY, April 15, 2025 Pfizer has stopped developing a once-daily pill to treat obesity after a person in a clinical trial showed signs of a possible liver injury.The company said the injury went away after the person stopped taking the drug, c.

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Quercetin Prevents Hyperuricemia Associated With Gouty Arthritis by Inactivating the NLRP3/NF‐κB Signaling Pathway

Chemical Biology and Drug Design

Quercetin inactivated the NF-B/NLRP3 signaling pathway to inhibit the inflammatory response and oxidative stress, thus preventing hyperuricemia combined with gouty arthritis. ABSTRACT Quercetin (QCT) shows great therapeutic potential for hyperuricemia (HUA) associated with gouty arthritis (GA). However, the underlying mechanism of QCT in inhibiting the progression of HUA and GA remains unclear.

Treatment 100
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Ensartinib

New Drug Approvals

Ensartinib X396 , X 396 1370651-20-9 C26H27Cl2FN6O3, 561.4 g/mol SMA5ZS5B22 6-amino-5-[(1 R )-1-(2,6-dichloro-3-fluorophenyl)ethoxy]- N -[4-[(3 R ,5 S )-3,5-dimethylpiperazine-1-carbonyl]phenyl]pyridazine-3-carboxamide 3-Pyridazinecarboxamide, 6-amino-5-((1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-N-(4-(((3R,5S)-3,5-dimethyl-1-piperazinyl)carbonyl)phenyl) 6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-[4-[(3R,5S)-3,5-dimethylpiperazine-1-carbonyl]phenyl]pyridazine-3-carboxamide 6-Amino

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