Drug Discovery World

FEBRUARY 13, 2024

DDW Editor Reece Armstrong asks whether artificial intelligence (AI) is the magic bullet many think it is. To reflect on another year in pharma is to think of the major stories and trends that have made impact within the industry. Often this can be drug approvals, exciting research into hard-to-treat indications, or even regulatory updates that enable players within the sector to utilise the latest technologies and drive therapies to market faster, ultimately benefitting patients.

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Small Molecule Drugs Therapies Pharmaceutical Companies 147

Codon

FEBRUARY 13, 2024

Tom Ireland writes about the companies and technologies that are reimagining phage therapy. Read it on our website here. Illustration by David S. Goodsell, RCSB Protein Data Bank and Scripps Research. doi: 10.2210/rcsb_pdb/goodsell-gallery-048 The Virus that Cures It’s been over 25 years since the science magazine Discover first ran an extraordinary article about how a long-forgotten medical treatment, used in the former Soviet country of Georgia, could save us from the growing threat of u

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Drug Discovery World

FEBRUARY 13, 2024

The UK’s Education Secretary Gillian Keegan attended a meeting with the Cell and Gene Therapy Catapult (CGT Catapult) to discuss the role of apprenticeships in the advanced therapies industry. The meeting, which took place at Teesside University’s National Horizons Centre in Darlington during National Apprenticeship Week, highlighted how apprenticeships are upskilling people all around the country and providing valuable support for the advanced therapies industry as it continues to grow.

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Chemical Biology and Drug Design

FEBRUARY 13, 2024

Alzheimer's disease (AD) is a common age-related neurodegenerative brain disorder characterized by the impairment in memory and other cognitive functions. Although there is currently no successful pharmacotherapy for AD, and researchers are continuously exploring the various pathogenesis of AD to develop potential therapeutic drugs. Abstract Alzheimer's disease (AD) is a common age-related neurodegenerative brain disorder characterized by the impairment in memory and other cognitive functions.

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Disease Treatment Therapies Research 100

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

FEBRUARY 13, 2024

A paper in the journal Science has identified a new class of BTK mutations that are susceptible to NX-2127, a novel BTK and IKZF1/3 degrader. The study ‘Kinase Impaired BTK Mutations Are Susceptible to Clinical Stage BTK and IKZF1/3 Degrader NX-2127’ elucidates a previously unappreciated oncogenic scaffold function of BTK responsible for clinical resistance to enzymatic inhibitors.

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Targeted Protein Degradation Science Treatment Research 130

Perficient: Drug Development

FEBRUARY 13, 2024

I (somehow) only recently discovered and began using the REST Client Visual Studio code extension created by Huachao Mao (GitHub: [link] ). It’s essentially an in-editor, Markdown-like HTTP request authoring and execution tool that allows developers to build a request (or multiple requests) in.http and/or.rest files. Think of it as a more Spartan, utilitarian version of Postman that lives right in the Visual Studio Code editor.

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Production 120

Drugs.com

FEBRUARY 13, 2024

TUESDAY, Feb. 13, 2024 -- Mammograms are a lifesaving misery for middle-aged women, but a new tool could make getting a breast cancer screening as easy as spitting.Literally.A new hand-held biosensor can detect breast cancer biomarkers from a tiny.

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Drug Discovery World

FEBRUARY 13, 2024

In this webinar, hosted by DDW and sponsored by Astrea Bioseparations, you will learn about how market growth can be sustained to maximise on opportunities in cell and gene therapy (CGT). You will hear from Doug Danison, Head of Commercial Strategy and Operations for Bayer CGT, Mark Treherne, Commercial Research Scientist and Chairperson at Spliceor, as well as Ian Scanlon, DSP Lead ATMP Purification at Astrea Bioseparations.

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Perficient: Drug Development

FEBRUARY 13, 2024

What is Microservices Architecture? Microservices Architecture Software development follows an architectural and organizational approach where small independent services communicate with each other through well-defined APIs. Overview of Microservices Architecture Microservices architecture provides a set of rules and guidelines to develop a project as a set of loosely coupled/de-coupled services, and this can be implemented using Spring Boot + Spring Cloud + Netflix and many other tools.

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Drug Discovery World

FEBRUARY 13, 2024

AM1476, a first-in-class, peripheral-acting serotonin receptor antagonist, has been granted US and EU Orphan Drug Designation as an anti-fibrotic treatment for systemic sclerosis. AM1476 is a selective peripheral-acting 5-HT2B receptor small molecule antagonist that can be delivered orally. It has demonstrated efficacy in in vitro and in vivo models of fibrosis, as well as favourable safety and pharmacokinetic profiles in Phase I clinical studies.

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Science Daily: Pharmacology News

FEBRUARY 13, 2024

Babies playfully tease others as young as eight months of age. Since language is not required for this behavior, similar kinds of playful teasing might be present in non-human animals. Now cognitive biologists and primatologists have documented playful teasing in four species of great apes. Like joking behavior in humans, ape teasing is provocative, persistent, and includes elements of surprise and play.

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Drugs.com

FEBRUARY 13, 2024

TUESDAY, Feb. 13, 2024 -- Maternal syphilis rates have tripled in recent years, putting thousands of newborns at risk for infection, a new U.S. government report shows.

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Government 103

Science Daily: Pharmacology News

FEBRUARY 13, 2024

More time stranded on land means greater risk of starvation for polar bears, a new study indicates. During three summer weeks, 20 polar bears closely observed by scientists tried different strategies to maintain energy reserves, including resting, scavenging and foraging. Yet nearly all of them lost weight rapidly: on average around 1 kilogram, or 2.2 pounds, per day.

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Drugs.com

FEBRUARY 13, 2024

TUESDAY, Feb. 13, 2024 -- Few can forget the haunting images of New York City bathed in a thick orange smog after smoke from Canadian wildfires swept southward last summer.Now, a new report from the First Street Foundation suggests these alarming.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Science Daily: Pharmacology News

FEBRUARY 13, 2024

Smelling a familiar scent can help depressed individuals recall specific autobiographical memories and potentially assist in their recovery.

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Drugs.com

FEBRUARY 13, 2024

TUESDAY, Feb. 13, 2024 — Researchers say they have developed a blood test for schizophrenia.More than 3 million people in the United States have schizophrenia, a disorder marked by hallucinations and delusions, or a related psychotic.

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Research 91

BioPharma Drive: Drug Pricing

FEBRUARY 13, 2024

Newly named partner Anthony Philippakis and managing partner Krishna Yeshwant spoke with BioPharma Dive about biotech’s newfound optimism and their investing “North Star.

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Drugs 89

Drugs.com

FEBRUARY 13, 2024

TUESDAY, Feb. 13, 2024 -- Replacing regular salt with a salt substitute can reduce high blood pressure in older adults, a new study has found.Older adults who use a salt substitute are 40% less likely to develop high blood pressure compared to.

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SCIENMAG: Medicine & Health

FEBRUARY 13, 2024

CLEVELAND — A recent study from researchers at University Hospitals (UH) Connor Whole Health and UH Rainbow Babies & Children’s Hospital describes a quality improvement project where pain screening procedures were embedded within an outpatient pediatric sickle cell disease (SCD) clinic.

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Disease Hospitals Research 77

Drugs.com

FEBRUARY 13, 2024

TUESDAY, Feb. 13, 2024 -- When a loved one has dementia, Valentine's Day can be bittersweet."When dementia enters someone's life, it can change many things, including the dynamic of their relationships," said Jennifer Reeder, director of.

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Science Daily: Pharmacology News

FEBRUARY 13, 2024

A team of scientists have demonstrated the first successful use of a neural prosthetic device to recall specific memories.

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Drugs.com

FEBRUARY 13, 2024

TUESDAY, Feb. 13, 2024 -- Preventing noise-related hearing loss from a loud concert, a banging jackhammer or a rifle blast could be as simple as managing levels of zinc within the inner ear, a new study reports.Such hearing loss stems from cellular.

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Science Research 86

addgene Blog

FEBRUARY 13, 2024

Monoclonal antibody drugs are popular therapeutics for a plethora of disease conditions, from cancer to autoimmune disorders. Antibodies administered as drugs are still immunogenic, meaning that they elicit an immune response from the body. Several factors contribute to the immunogenicity of a drug including the product origin; purity, mechanism, and stability; and sequence of biologic product, mode of administration, and dose (Lu et.al., 2020).

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Immune Response Drugs Production Disease 76

Drugs.com

FEBRUARY 13, 2024

TUESDAY, Feb. 13 -- Two of the most common pregnancy complications for women, high blood pressure and gestational diabetes, could jeopardize the future heart health of their children, a new study suggests. Researchers found that the children.

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Research 84

SCIENMAG: Medicine & Health

FEBRUARY 13, 2024

Living organisms often create what is needed for life from scratch. Credit: Photo by Max Esterhuizen for Virginia Tech. Living organisms often create what is needed for life from scratch. For humans, this process means the creation of most essential compounds needed to survive.

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Research 75

Drugs.com

FEBRUARY 13, 2024

TUESDAY, Feb. 13, 2024 -- Nearly 1 in every 10 women infected with COVID during pregnancy will go on to develop long COVID, a new study says.A little more than 9% of pregnant women developed long COVID six or more months after their initial.

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Antidote

FEBRUARY 13, 2024

In the human eye, the cornea's function is to refract light onto the lens and retina to maintain vision function — but this role is dependent on the corneal epithelium’s ability to renew itself continually. The corneal epithelium provides a barrier to protect the interior of the cornea from damage, but when it becomes injured, this function becomes impaired.

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Treatment 72

Drugs.com

FEBRUARY 13, 2024

TUESDAY, Feb. 13, 2024 -- The care you receive in a medical emergency may hinge strongly on where you are when you need it.That's a key takeaway from a comprehensive review of the nation's emergency medical service (EMS) systems by researchers at.

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Research 79

BioPharma Drive: Drug Pricing

FEBRUARY 13, 2024

BioAge’s Series D will fund a study combining its medicine with Eli Lilly’s Zepbound, a strategy the company hopes could help people lose weight while maintaining muscle mass.

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Drugs 72

Science Daily: Pharmacology News

FEBRUARY 13, 2024

Researchers report successful results from a hand-held breast cancer screening device that can detect breast cancer biomarkers from a tiny sample of saliva. Their design uses common components, such as widely available glucose testing strips and the open-source hardware-software platform Arduino. A saliva sample is placed on the paper strip, which has been treated with specific antibodies that interact with the targeted cancer biomarkers.

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Research 77

BioPharma Drive: Drug Pricing

FEBRUARY 13, 2024

The biotech's drug quickly alleviated symptoms of the swelling attacks associated with hereditary angioedema, supporting the idea it could be an oral alternative to existing medicines.

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Drugs 69

Drugs.com

FEBRUARY 13, 2024

TUESDAY, Feb. 13, 2024 -- The red meat diet associated with masculinity could be the worst thing for men dealing with prostate cancer, a new study says.Prostate cancer patients who limit meat and dairy but eat lots of plant-based foods tend to.

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Treatment 75

Cytel

FEBRUARY 13, 2024

Written by Boaz N. Adler, MPA, Director, Global Product Engagement, and Valeria Mazzanti, MPH, Associate Director, Customer Success Rare disease studies come with their own unique challenges, particularly limited patient populations. However, there are a number of adaptive clinical trial design strategies that can be used to mitigate the challenge of hard-to-recruit patient populations and associated trial risks.

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Disease Clinical Trials Trials Production 69

SCIENMAG: Medicine & Health

FEBRUARY 13, 2024

CLEVELAND – Jeanne Lackamp, MD, DFAPA, FACLP, has been selected to serve as Chair of Department of Psychiatry, Psychiatrist in Chief for University Hospitals (UH), and Director of the UH Behavioral Health Institute.

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Hospitals 67