Total Synthesis of Tagitinins, Goyazensolide and RelatedFuranoheliangolides and their Covalent Interaction withImportin-5 (IPO5)
Covalent Modifiers
NOVEMBER 2, 2024
W Liu, R Patouret, E Peev, S Barluenga, N Winssinger Helvetica Chimica Acta , 2024 [link] Herein, we detail an extension of our research on the synthesis of a small library of furanoheliangolides and the characterization of the covalent interaction between goyazensolide and IPO5. Using a build‐couple‐pair strategy, we assembled a small library of germacrene‐type lactones and diversified them into eight groups of structurally different analogues.
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