Sat.May 03, 2025 - Fri.May 09, 2025

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Too Much Cinnamon May Interfere With Some Medications, Study Shows

Drugs.com

MONDAY, May 5, 2025 Consuming too much cinnamon might affect how your body absorbs some medications, new research shows.The study published in the June issue of the journal Food Chemistry: Molecular Sciences looked at how cinnamon and its key.

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Residue-Selective Inhibitors Discovery via Covalent DNA-Encoded Chemical Libraries with Diverse Warheads

Covalent Modifiers

Xinyuan Wu, Jiayi Pan, Rufeng Fan, Yiwei Zhang, Chao Wang, Guoliang Wang, Jiaxiang Liu, Mengqing Cui, Jinfeng Yue, Rui Jin, Zhiqiang Duan, Mingyue Zheng, Lianghe Mei, Lu Zhou, Minjia Tan, Jing Ai, and Xiaojie Lu Journal of the American Chemical Society 2025 147 (18), 15469-15481 DOI: 10.1021/jacs.5c01712 Covalent small molecule drugs have emerged as a crucial support in precision therapy due to their high selectivity and robust potency.

DNA
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Are you curious? It might help you stay sharp as you age

Science Daily: Pharmacology News

Psychology literature has shown that curiosity tends to decline with age. Psychologists shows one type of curiosity can increase well into old age, contradicting prior research. Older adults who maintain curiosity and want to learn new things relevant to their interests may be able to offset or even prevent Alzheimer's disease. Conversely, those who show muted curiosity and disinterest may be at risk for dementia.

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Common Errors When Using GraphQL with Optimizely

Perficient: Drug Development

What is GraphQL? GraphQL is a powerful query language for APIs that allows clients to request only the data they need. Optimizely leverages GraphQL to serve content to your platform agnostic presentation layer. This approach to headless architecture with Optimizely CMS is gaining traction in the space and developers often encounter new challenges when transitioning from the more common MVC approach.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Man Bitten by Snakes 200 Times May Help Create New Antivenom

Drugs.com

MONDAY, May 5, 2025 Tim Friede has survived hundreds of snakebites on purpose. For nearly two decades, he let some of the worlds most dangerous snakes sink their fangs into his arms, all for science.Now, his bold experiment could potentially he.

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Elacestrant 

New Drug Approvals

Elacestrant (6 R )-6-[2-[ethyl-[[4-[2-(ethylamino)ethyl]phenyl]methyl]amino]-4-methoxyphenyl]-5,6,7,8-tetrahydronaphthalen-2-ol (6R)-6-{2-[ethyl({4-[2-(ethylamino)ethyl]phenyl}methyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol FDA 1/27/2023, Orserdu WeightAverage: 458.646 Monoisotopic: 458.293328472 Chemical FormulaC 30 H 38 N 2 O 2 To treat estrogen receptor-positive, human epidermal growth factor receptor 2-negative, ESR1-mutated, advanced or metastatic breast cancer with disease

FDA

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AI specialist Recursion trims pipeline in latest shakeup

BioPharma Drive: Drug Pricing

The cuts to three advanced drug programs were “inevitable” given the company’s “unsustainable cash burn,” one analyst wrote in a note to investors.

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Wildfire Smoke Flooded ERs With Asthma Cases

Drugs.com

MONDAY, May 5, 2025 -- Asthma attacks caused emergency room surges during the 2023 Canadian wildfires, with smoke-filled air sending hundreds to the hospital daily, a new study says.Daily asthma-related visits to Ontario hospitals increased nearly.

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Building the requisite clinical development infrastructure for medical innovation to thrive

Drug Target Review

Millions of people around the world each year face serious illness, with the promise of groundbreaking treatment being just out of reach. They wait for the therapies that could significantly improve their quality of life or even save it knowing approval could be years or decades away. In an era where science and technology are surpassing what was ever thought possible, the need for the biotech industry to adapt, respond and evolve as quickly and cost efficiently as possible is more urgent than

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Black tea and berries could contribute to healthier aging

Science Daily: Pharmacology News

Higher intakes of black tea, berries, citrus fruits and apples could help to promote healthy aging, new research has found.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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PTC stock slides on new data for Huntington’s drug

BioPharma Drive: Drug Pricing

While updated study results confirmed the drug lowers a target protein, the therapy's effect on clinical outcomes was less clear-cut.

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New Molecular Test Could Double Leukemia Survival Rates

Drugs.com

MONDAY, May 5, 2025 Testing positive for leukemia actually saved the life of 51-year-old Jan Leahy, a business process owner from Wimbledon, England.Leahy benefitted from a clinical trial evaluating a new bone marrow test that can detect a p.

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Pirtobrutinib

New Drug Approvals

Pirtobrutinib CAS 2101700-15-4 JAYPIRCA RXC-005 LY3527727 LOXO-305 WHO 11681 WeightAverage: 479.436 Monoisotopic: 479.158052208 Chemical FormulaC 22 H 21 F 4 N 5 O 3 5-amino-3-[4-[[(5-fluoro-2-methoxybenzoyl)amino]methyl]phenyl]-1-[(2 S )-1,1,1-trifluoropropan-2-yl]pyrazole-4-carboxamide FDA 2023, 1/27/2023, Jaypirca To treat relapsed or refractory mantle cell lymphoma in adults who have had at least two lines of systemic therapy, including a BTK inhibitor Drug Trials Snapshot Pirtobrutinib , so

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Spanking and other physical discipline lead to exclusively negative outcomes for children in low- and middle-income countries

Science Daily: Pharmacology News

Physically punishing children in low- and middle-income countries (LMICs) has exclusively negative outcomes -- including poor health, lower academic performance, and impaired social-emotional development -- yielding similar results to studies in wealthier nations, finds a new analysis.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Deerfield secures more than $600M for its next biotech venture fund

BioPharma Drive: Drug Pricing

The firm, a prolific backer of drug startups, will use the cash to back companies working on therapeutics, medical devices and healthcare services.

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FDA Approves SAPIEN 3 Platform for Asymptomatic Severe Aortic Stenosis

Drugs.com

MONDAY, May 5, 2025 -- The U.S. Food and Drug Administration has approved the SAPIEN 3 platform, a transcatheter aortic valve replacement (TAVR) therapy, for patients with severe aortic stenosis without symptoms. The approval is the first for TAVR.

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Novel Pharmaceutical Strategies and Business Models: The Rise of Telehealth Companies Like Ro and Hims & Hers

Drug Patent Watch

"The Telehealth Revolution: How D2C Pharmacies Are Redefining the Industry In a seismic shift, direct-to-consumer (D2C) pharmacies like Ro, Hims, and Hers are upending traditional healthcare business models, leveraging telehealth to deliver convenient, affordable, and personalized care to millions. But what's driving this transformation, and what does it mean for the future of pharmaceuticals?

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Discovery of dopamine receptors in a previously overlooked part of the brain sheds light on the complex circuitry for anxiety and depression

Science Daily: Pharmacology News

Researchers have discovered distinct roles for two dopamine receptors located on nerve cells within the portion of the brain that controls approach vs. avoidance behavior.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Phase-by-Phase Clinical Trial Costs: What Every Sponsor Needs to Know!

ProRelix Research

This report provides a comprehensive breakdown of clinical trial costs by phase and therapeutic area, with a focus on key cost components including per-patient costs, total costs, CRO fees, and […] The post Phase-by-Phase Clinical Trial Costs: What Every Sponsor Needs to Know! appeared first on ProRelix Research.

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New Drug Could Quell Uncontrolled High Blood Pressure

Drugs.com

MONDAY, May 5, 2025 An experimental drug might help people with uncontrolled high blood pressure, according to early clinical trial results.People taking lorundrostat experienced twice the decline in their systolic blood pressure than people t.

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Claritas Rx’s Webinar: Achieve Specialty Pharma Success with AI: Enhance Care, Elevate Fill Rates by 20% and Improve Patient Adherence

Drug Channels

Participate in Claritas Rx's upcoming webinar to learn innovative strategies designed to increase your fill rates by 20% and enhance patient adherence. The webinar seeks to elevate your operational efficiency and improve patient care standards. Join Claritas Rx experts as they lead you through methods intended to optimize patient care coordination, featuring an in-depth real-world case study that demonstrates the impact of these approaches.

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Ancient Andes society used hallucinogens to strengthen social order

Science Daily: Pharmacology News

Snuff tubes uncovered at Chavin de Huantar in Peru reveal how leaders used mystical experiences to cement their power.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Companies Shipping Chemicals: “Know the One You’re Dancing With”

FDA Law Blog: Biosimilars

By Larry K. Houck Drug Enforcement Administration (DEA) civil monetary settlements involving listed chemicals that do not include pseudoephedrine are rare. Even more scarce are DEA civil settlements with non-registrants. (By my count there have been only ten since 2000). When one comes along, it is worthwhile to sit up and take notice. On March 26th the U.S.

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Men Worse Off Than Women For 20 Top Health Problems Worldwide

Drugs.com

MONDAY, May 5, 2025 Men are much more likely than women to die early from the worlds 20 leading health problems, a new global study shows.Sickness and death was higher in men than women in 2021 for 13 of the top 20 causes of injury and illness, i.

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Exploring the Role of South Africa in the Global Pharmaceutical Landscape

Drug Patent Watch

"As the world grapples with the complexities of global healthcare, one nation is rewriting the rules of the pharmaceutical game: South Africa. In a groundbreaking new report, we delve into the pivotal role the country is playing in shaping the future of medicine. From pioneering generic drug production to challenging Big Pharma's dominance, South Africa is redefining what it means to be a leader in the global pharmaceutical landscape.

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Saving the Asian 'unicorn' -- if it still exists

Science Daily: Pharmacology News

The saola, an antelope-like bovine, is one of the world's rarest and most endangered mammals. In fact, it hasn't been observed in over 10 years. Researchers have now mapped the saola's complete genome, and they have used that knowledge to estimate the chances of saving it -- if it still exists.

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Prasad’s FDA appointment pressures cell and gene therapy stocks

BioPharma Drive: Drug Pricing

A vocal opponent of his predecessor Peter Marks, Vinay Prasad will now lead the office tasked with reviewing some genetic medicines, adding more uncertainty to an already struggling field of research.

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Experimental Drug Lorundrostat Could Quell Uncontrolled High Blood Pressure

Drugs.com

MONDAY, May 5, 2025 — An experimental drug might help people with uncontrolled high blood pressure, according to early clinical trial results. People taking lorundrostat experienced twice the decline in their systolic blood pressure than.

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Follow These Regulations for Herbal Clinical Trials in India

ProRelix Research

AuthoritativeregulationsshapingHerbalClinicalTrialsinIndia,detailingAYUSHprotocols,CDSCOmandates,andGCPstandardstoupholdscientificrigorandregulatoryexcellence. India, the cradle of Ayurveda and centuries-old herbal traditions, is rapidly emerging as a global leader in evidence-based herbal medicine. With the increasing demand for natural therapies backed by […] The post Follow These Regulations for Herbal Clinical Trials in India appeared first on ProRelix Research.

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A long and ongoing look at the secrets of human longevity and healthy aging

Science Daily: Pharmacology News

Researchers participating in the Cilento Initiative on Aging Outcomes or CIAO study will gather in Acciaroli (Pollica-Cilento) Salerno, Italy to review a decade of work and plan their next steps. Launched in 2016, the CIAO study seeks to identify key factors (biological, psychological and social) that promote healthy aging and extreme longevity.

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Gilead, bracing for tariffs, joins peers in US drug production push

BioPharma Drive: Drug Pricing

The company added to a recent flurry of pledges by pharmaceutical companies, promising $11 billion in new capital and operational investments in U.S. drug manufacturing.

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Can Kissing Pass Gluten? New Findings For Celiac Patients

Drugs.com

MONDAY, May 5, 2025 Can gluten be passed on through a kiss?Its a concern for some folks with celiac disease, but a new study says worry not. People with celiac disease had no problems after kissing a partner whod just eaten a stack of saltine cr.