Sat.Apr 27, 2024 - Fri.May 03, 2024

article thumbnail

$15 million CIRM grant supports allogeneic CAR-T in renal cell carcinoma

Drug Discovery World

Allogene Therapeutics has received a $15 million grant from the California Institute for Regenerative Medicine (CIRM) to support the development of ALLO-316, an AlloCAR T investigational product for the treatment of advanced or metastatic renal cell carcinoma (RCC). ALLO-316 targets CD70, which is highly expressed in RCC and is also selectively expressed in several cancers.

Therapies 162
article thumbnail

Stretchable e-skin could give robots human-level touch sensitivity

Science Daily: Pharmacology News

A stretchy electronic skin could equip robots and other devices with the same softness and touch sensitivity as human skin, opening up new possibilities to perform tasks that require a great deal of precision and control of force.

135
135
Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Trending Sources

article thumbnail

CG follows big IPO with new results for bladder cancer drug

BioPharma Drive: Drug Pricing

Newly disclosed Phase 3 results presented Friday match findings the biotech disclosed last year, while offering a more comprehensive look at how its drug stacks up to rival therapies.

Drugs 120
article thumbnail

Major Women's Health Study Supports Hormone Replacement Therapy in Early Menopause

Drugs.com

WEDNESDAY, May 1, 2024 -- Hormone replacement therapy can safely ease middle-aged women’s symptoms during early menopause, data from a major women’s health study show. Women younger than 60 can use hormone replacement to treat symptoms.

Therapies 116
article thumbnail

How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

article thumbnail

Study proves value of infection studies in developing new vaccines

Drug Discovery World

A study led by the University of Oxford has successfully investigated human immunity against Covid-19 in people who already have antibodies, with the aim of advancing future vaccines and treatments. The results suggest that previous infection, together with vaccination, offers strong protection against the original Covid-19 strain. Over 99% of the UK population and 59% of the world’s population is seropositive, which means they already have antibodies against Covid-19.

Vaccine 147
article thumbnail

Scientists work out the effects of exercise at the cellular level

Science Daily: Pharmacology News

The health benefits of exercise are well known but new research shows that the body's response to exercise is more complex and far-reaching than previously thought. In a study on rats, a team of scientists has found that physical activity causes many cellular and molecular changes in all 19 of the organs they studied in the animals.

Research 136

More Trending

article thumbnail

Avoid Raw Milk to Cut Risk of Bird Flu, Officials Urge

Drugs.com

WEDNESDAY, May 1, 2024 -- People drinking raw unpasteurized milk are at risk for potentially contracting bird flu, the U.S. Food and Drug Administration warned Wednesday.“We continue to strongly advise against the consumption of raw milk,” Dr.

Drugs 114
article thumbnail

Cell and gene therapy: Global Innovation and Opportunity

Drug Discovery World

Hailed as a revolution in the treatment of many diseases, cell and gene therapy (CGT) is the fastest growing area of therapeutics. 2023 was a record year for CGTs, with seven new CGTs approved by the US Food and Drug Administration (FDA) across a variety of different disease areas. Perhaps most significantly, Casgevy (or exa-cel) from Vertex Pharmaceuticals and CRISPR Therapeutics, was approved to treat sickle cell disease and became the first gene therapy that uses CRISPR gene editing. 2024 is

Therapies 147
article thumbnail

Did a magnetic field collapse trigger the emergence of animals?

Science Daily: Pharmacology News

Researchers uncovered compelling evidence that Earth's magnetic field was in a highly unusual state when the macroscopic animals of the Ediacaran Period -- 635 to 541 million years ago -- diversified and thrived. Their study raises the question of whether these fluctuations in Earth's ancient magnetic field led to shifts in oxygen levels that may have been crucial to the proliferation of life forms millions of years ago.

Research 129
article thumbnail

Delphia starts up with $67M to make a new type of cancer drug

BioPharma Drive: Drug Pricing

Delphia is developing medicines designed to overstress certain cellular pathways to the point tumor cells die, an approach the biotech calls “activation lethality.

Drugs 116
article thumbnail

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

article thumbnail

Vaccines Have Saved 154 Million Lives, Mostly Babies, Over Past 50 Years

Drugs.com

MONDAY, April 29, 2024 -- Global vaccination efforts have saved an estimated 154 million lives, including 101 million infants, a new study led by the World Health Organization (WHO) shows.Immunization has contributed more to the health and survival.

Vaccine 116
article thumbnail

Cancer vaccine developer secures £12.8m seed financing

Drug Discovery World

Oxford University spin-out Infinitopes Precision Immunomics has completed a £12.8 ($16) million seed funding round led by Octopus Ventures. The round was heavily oversubscribed, also drawing in funds from Cancer Research Horizons, Cancer Research Institute, CRIS Cancer Foundation, Kindred Capital, Manta Ray, Martlet Capital, Meltwind Advisory, Saras Capital, Wilbe Capital, and expert angel investors.

Vaccine 147
article thumbnail

Significant new discovery in teleportation research -- Noise can improve the quality of quantum teleportation

Science Daily: Pharmacology News

Researchers succeeded in conducting an almost perfect quantum teleportation despite the presence of noise that usually disrupts the transfer of quantum state.

Research 132
article thumbnail

Amgen shares soar as executives outline obesity drug push

BioPharma Drive: Drug Pricing

The company said data for its Wegovy competitor was promising enough to move the drug into late-stage testing, triggering a stock jump that added billions to Amgen’s market value.

Drugs 110
article thumbnail

Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

article thumbnail

Quit-Smoking Meds Not Working for You? Try Upping the Dose

Drugs.com

FRIDAY, May 2, 2024 -- Folks struggling to quit smoking might need a bump up on the dose of medication they’re using to help them stop, according to new clinical trial results.Patients are more likely to successfully quit if the dose of their.

article thumbnail

Therapeutic antibody potential in 2024

Drug Discovery World

DDW’s Megan Thomas speaks to industry experts and thought leaders about the potential for therapeutic antibodies in 2024. Many of the best-selling drugs in 2023 were monoclonal antibody (mAB) therapies, including Keytruda (pembrolizumab), Humira (adalimumab), and Dupixent (dupilumab) 1. This won’t come as a surprise when you look at industry milestones achieved in 2023 and looking ahead, this shows no signs of slowing down.

article thumbnail

More plants on the menu of ancient hunter-gatherers

Science Daily: Pharmacology News

It has long been thought that meat played an important role in the diet of hunter-gatherers before the Neolithic transition. However, due to the scarcity of well-preserved human remains from Paleolithic sites, little information exists about the dietary habits of pre-agricultural human groups. A new study challenges this notion by presenting compelling isotopic evidence of a strong preference for plants among 15,000-year-old hunter-gatherers from Morocco.

123
123
article thumbnail

GSK raises forecasts on strong vaccine, HIV drug sales

BioPharma Drive: Drug Pricing

Sales of the shingles vaccine Shingrix and the RSV shot Arexvy helped fuel quarterly revenue totals that surpassed analyst expectations, though the company warned momentum could slow in the months ahead.

Vaccine 112
article thumbnail

Painless Skin Patch Could Deliver Vaccines to Kids

Drugs.com

TUESDAY, April 30, 2024 -- Kids who don’t like vaccination shots might soon have an alternative in a painless skin patch, researchers say.More than 90% of 190 Gambian infants were protected from measles and all were protected from rubella after.

Vaccine 111
article thumbnail

Selective Translation Regulator Inhibitors: Depriving cancer of what it needs

Drug Discovery World

In the In Conversation With series, a part of the free DDW podcast, DDW speaks with members of the drug discovery industry about their work and how it helps turn science into business. In this episode, Megan Thomas is in conversation with Steve Worland, CEO of eFFECTOR. eFFECTOR is a company targeting three distinct targets central to the eIF4F translation initiation complex: MNK, eIF4A and eIF4E.

article thumbnail

Earth-like environment likely on ancient Mars

Science Daily: Pharmacology News

A research team using the ChemCam instrument onboard NASA's Curiosity rover discovered higher-than-usual amounts of manganese in lakebed rocks within Gale Crater on Mars, which indicates that the sediments were formed in a river, delta, or near the shoreline of an ancient lake.

Research 121
article thumbnail

Enlaza gets JP Morgan, Regeneron backing for covalent biologics

BioPharma Drive: Drug Pricing

The funds will help the cancer-focused startup Enlaza bring “several development candidates” towards human testing in the next few years, its CEO said.

117
117
article thumbnail

5 Obtrusive Blockers to Avoid as a Servant Leader

Perficient: Drug Development

We’ve all heard of servant leadership. The concept of “being a servant” to your teams and treating employees as critical individuals to be cultivated and empowered, has strong merit. However, many organizations fall short, with those at the top of the hierarchy viewing employees as interchangeable cogs in the corporate machine. Instead of diving deep into the theories, practices, and benefits of servant leadership, I will focus on a specific, related principle or mind-set: being unobtrusive.

article thumbnail

Cutting a path through the weeds with cannabis research

Drug Discovery World

Dr Currien MacDonald, Medical Chair Director at WCG, discusses the challenges and opportunities presented by cannabis research. The recent interest in cannabinoids as potential sources for medicinal use has been a long time coming. Advances in brain science and modern chemistry are supporting a new generation of investigation into cannabinoids, the active compounds in the cannabis plant.

Research 147
article thumbnail

Every breath you take: Study models the journey of inhaled plastic particle pollution

Science Daily: Pharmacology News

With recent studies having established the presence of nano and microplastic particles in the respiratory systems of both human and bird populations, new research has modeled what happens when people breathe in different kinds of plastic particles and where they end up.

Research 120
article thumbnail

Lilly hikes revenue forecast by $2B as GLP-1 drug sales climb

BioPharma Drive: Drug Pricing

Supply continues to be tight, however, and the company anticipates further sales growth to be limited by how quickly it can bring on additional production capacity.

article thumbnail

Gas Stoves Could Leave Your Lungs Vulnerable to Nitrogen Dioxide

Drugs.com

FRIDAY, May 3, 2024 -- People in homes with gas or propane stoves regularly breathe in unhealthy levels of nitrogen dioxide, a new study says.Typical use of these stoves increases exposure to nitrogen dioxide (NO2) by an estimated 4 parts per.

105
105
article thumbnail

This week in drug discovery (29 April – 3 May) 

Drug Discovery World

News round-up for 29 April – 3 May by DDW Multimedia Editor Megan Thomas. The ongoing innovation and development in the drug discovery sector relies on a number of moving parts, one of which is financial support and backing. Whether it is successful seed funding or dedicated investment, this money enables scientists to produce top-quality research which will in turn result in discoveries and drugs that help tackle disease and areas of unmet need.

Drugs 130
article thumbnail

Marriage of synthetic biology and 3D printing produces programmable living materials

Science Daily: Pharmacology News

Scientists are harnessing cells to make new types of materials that can grow, repair themselves and even respond to their environment. These solid 'engineered living materials' are made by embedding cells in an inanimate matrix that's formed in a desired shape. Now, researchers have 3D printed a bioink containing plant cells that were then genetically modified, producing programmable materials.

article thumbnail

FTC targets ‘junk patents’ on Ozempic, other top drugs

BioPharma Drive: Drug Pricing

The move broadens the antitrust regulator’s campaign against allegedly “improper or inaccurate” patent listings by drugmakers to include top-selling medicines for weight loss, diabetes, asthma and COPD.

article thumbnail

More Evidence Supports Psilocybin's Antidepressant Powers

Drugs.com

THURSDAY, May 2, 2024 -- The active chemical in magic mushrooms could prove to be a powerful antidepressant, a new review finds.Psilocybin outperformed a variety of “control” treatments in easing symptoms of depression, researchers reported May.

Treatment 105
article thumbnail

$75m in funding to develop tenosynovial giant cell tumour mAb 

Drug Discovery World

SynOx Therapeutics has closed a $75m Series B financing round, which will be used to generate registrational Phase III clinical and CMC data for emactuzumab, the company’s potentially best-in-class CSF-1(R) inhibiting monoclonal antibody (mAb) for the treatment of tenosynovial giant cell tumour (TGCT). TGCT is a type of tumour that affects the soft tissue lining of joints and tendons and is a highly debilitating disease often impacting large, important joints such as the knee, hip and ankle.

Disease 130
article thumbnail

Researchers identify over 2,000 genetic signals linked to blood pressure in study of over one million people

Science Daily: Pharmacology News

Researchers have discovered over a hundred new regions of the human genome, also known as genomic loci, that appear to influence a person's blood pressure. In total, over 2,000 independent genetic signals for blood pressure are now reported, demonstrating that blood pressure is a highly complex trait influenced by thousands of different genetic variants.

Research 116
article thumbnail

Pfizer’s strong Vyndaqel sales draw attention to rare disease drug’s patent life

BioPharma Drive: Drug Pricing

Sales of the transthyretin amyloidosis treatment widely beat Wall Street forecasts in the first quarter. The company aims to extend its patent exclusivity.

Disease 115