Sat.Apr 27, 2024 - Fri.May 03, 2024

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Stretchable e-skin could give robots human-level touch sensitivity

Science Daily: Pharmacology News

A stretchy electronic skin could equip robots and other devices with the same softness and touch sensitivity as human skin, opening up new possibilities to perform tasks that require a great deal of precision and control of force.

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CG follows big IPO with new results for bladder cancer drug

BioPharma Drive: Drug Pricing

Newly disclosed Phase 3 results presented Friday match findings the biotech disclosed last year, while offering a more comprehensive look at how its drug stacks up to rival therapies.

Drugs 125
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#WhyIScience Q&A: How a computational biologist balances work with life as an elite rower

Broad Institute

#WhyIScience Q&A: How a computational biologist balances work with life as an elite rower By Allessandra DiCorato May 2, 2024 Breadcrumb Home #WhyIScience Q&A: How a computational biologist balances work with life as an elite rower Liz Martin reflects on how her career in cancer biology complements her intense training on the water. By Allessandra DiCorato May 2, 2024 Credit: Lisa Worthy Liz Martin, an elite rower and a computational biologist at the Broad, in a lightweight women's quad at the 2

Science 124
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Targeting PFC dysfunction in pain [Minireview]

ASPET

The prefrontal cortex (PFC) has justifiably become a significant focus of chronic pain research. Collectively, decades of rodent and human research have provided strong rationale for studying the dysfunction of the PFC as a contributing factor in the development and persistence of chronic pain and as a key supraspinal mechanism for pain-induced comorbidities such as anxiety, depression and cognitive decline.

Research 100
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Scientists work out the effects of exercise at the cellular level

Science Daily: Pharmacology News

The health benefits of exercise are well known but new research shows that the body's response to exercise is more complex and far-reaching than previously thought. In a study on rats, a team of scientists has found that physical activity causes many cellular and molecular changes in all 19 of the organs they studied in the animals.

Research 143
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Structural and molecular insights from dual inhibitors of EGFR and VEGFR2 as a strategy to improve the efficacy of cancer therapy

Chemical Biology and Drug Design

Simultaneous inhibition of EGFR and VEGFR2 may improve the efficacy of cancer treatment. Understanding the macromolecular structures, activation mechanism, and pharmacophore features of both kinase inhibitors and their selectivity is essential in designing dual inhibitors of EGFR and VEGFR2. Abstract Epidermal growth factor receptor (EGFR) and vascular endothelial growth factor 2 (VEGFR2) are known as valid targets for cancer therapy.

Therapies 100

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Major Women's Health Study Supports Hormone Replacement Therapy in Early Menopause

Drugs.com

WEDNESDAY, May 1, 2024 -- Hormone replacement therapy can safely ease middle-aged women’s symptoms during early menopause, data from a major women’s health study show. Women younger than 60 can use hormone replacement to treat symptoms.

Therapies 116
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Did a magnetic field collapse trigger the emergence of animals?

Science Daily: Pharmacology News

Researchers uncovered compelling evidence that Earth's magnetic field was in a highly unusual state when the macroscopic animals of the Ediacaran Period -- 635 to 541 million years ago -- diversified and thrived. Their study raises the question of whether these fluctuations in Earth's ancient magnetic field led to shifts in oxygen levels that may have been crucial to the proliferation of life forms millions of years ago.

Research 138
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5 Obtrusive Blockers to Avoid as a Servant Leader

Perficient: Drug Development

We’ve all heard of servant leadership. The concept of “being a servant” to your teams and treating employees as critical individuals to be cultivated and empowered, has strong merit. However, many organizations fall short, with those at the top of the hierarchy viewing employees as interchangeable cogs in the corporate machine. Instead of diving deep into the theories, practices, and benefits of servant leadership, I will focus on a specific, related principle or mind-set: being unobtrusive.

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Delphia starts up with $67M to make a new type of cancer drug

BioPharma Drive: Drug Pricing

Delphia is developing medicines designed to overstress certain cellular pathways to the point tumor cells die, an approach the biotech calls “activation lethality.

Drugs 123
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Vaccines Have Saved 154 Million Lives, Mostly Babies, Over Past 50 Years

Drugs.com

MONDAY, April 29, 2024 -- Global vaccination efforts have saved an estimated 154 million lives, including 101 million infants, a new study led by the World Health Organization (WHO) shows.Immunization has contributed more to the health and survival.

Vaccine 116
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Significant new discovery in teleportation research -- Noise can improve the quality of quantum teleportation

Science Daily: Pharmacology News

Researchers succeeded in conducting an almost perfect quantum teleportation despite the presence of noise that usually disrupts the transfer of quantum state.

Research 139
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Cell Line Services FAQ

Crown Bioscience

This post delves into some frequently asked questions about Omni Screen and its unique capabilities in providing compliant, large-scale cell line screening solutions that are not only cutting-edge but also aligned with industry standards and regulations. Whether you're a researcher, a biotech professional, or someone keen on understanding the nuances of cell line screening, this discussion will provide valuable insights into how Crown Bioscience can support your scientific endeavors.

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Enlaza gets JP Morgan, Regeneron backing for covalent biologics

BioPharma Drive: Drug Pricing

The funds will help the cancer-focused startup Enlaza bring “several development candidates” towards human testing in the next few years, its CEO said.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Quit-Smoking Meds Not Working for You? Try Upping the Dose

Drugs.com

FRIDAY, May 2, 2024 -- Folks struggling to quit smoking might need a bump up on the dose of medication they’re using to help them stop, according to new clinical trial results.Patients are more likely to successfully quit if the dose of their.

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More plants on the menu of ancient hunter-gatherers

Science Daily: Pharmacology News

It has long been thought that meat played an important role in the diet of hunter-gatherers before the Neolithic transition. However, due to the scarcity of well-preserved human remains from Paleolithic sites, little information exists about the dietary habits of pre-agricultural human groups. A new study challenges this notion by presenting compelling isotopic evidence of a strong preference for plants among 15,000-year-old hunter-gatherers from Morocco.

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Using Optimizely Content Delivery API for data migration

Perficient: Drug Development

Optimizely Content Delivery API is very well known for building headless CMS, to connect to Single Page Apps, mobile apps, etc. However I also found that come in handy in terms of data migration. With the Content Delivery API, you can easily retrieve detailed information of source content in JSON format and map it to your target application. In this article, I will give a brief instruction on how to migrate data between Optimizely Content Cloud applications using the API.

Packaging 105
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GSK raises forecasts on strong vaccine, HIV drug sales

BioPharma Drive: Drug Pricing

Sales of the shingles vaccine Shingrix and the RSV shot Arexvy helped fuel quarterly revenue totals that surpassed analyst expectations, though the company warned momentum could slow in the months ahead.

Vaccine 118
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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More Evidence Supports Psilocybin's Antidepressant Powers

Drugs.com

THURSDAY, May 2, 2024 -- The active chemical in magic mushrooms could prove to be a powerful antidepressant, a new review finds.Psilocybin outperformed a variety of “control” treatments in easing symptoms of depression, researchers reported May.

Treatment 105
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Every breath you take: Study models the journey of inhaled plastic particle pollution

Science Daily: Pharmacology News

With recent studies having established the presence of nano and microplastic particles in the respiratory systems of both human and bird populations, new research has modeled what happens when people breathe in different kinds of plastic particles and where they end up.

Research 130
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Perficient Awarded as HCL Software’s Gold Reseller Award

Perficient: Drug Development

We are proud to announce Perficient has been awarded HCL Software’s Gold Reseller Award! This award comes as recognition for our continued collaboration and outstanding performance in regard to sales and delivery in 2023. As an HCL Software strategic partner, we actively drive innovation into HCL’s roadmap and collaborate closely from a product innovation and support perspective.

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Amgen shares soar as executives outline obesity drug push

BioPharma Drive: Drug Pricing

The company said data for its Wegovy competitor was promising enough to move the drug into late-stage testing, triggering a stock jump that added billions to Amgen’s market value.

Drugs 117
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Gas Stoves Could Leave Your Lungs Vulnerable to Nitrogen Dioxide

Drugs.com

FRIDAY, May 3, 2024 -- People in homes with gas or propane stoves regularly breathe in unhealthy levels of nitrogen dioxide, a new study says.Typical use of these stoves increases exposure to nitrogen dioxide (NO2) by an estimated 4 parts per.

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Earth-like environment likely on ancient Mars

Science Daily: Pharmacology News

A research team using the ChemCam instrument onboard NASA's Curiosity rover discovered higher-than-usual amounts of manganese in lakebed rocks within Gale Crater on Mars, which indicates that the sediments were formed in a river, delta, or near the shoreline of an ancient lake.

Research 136
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Advancing Clinical Data Management into a New Era

Quanticate

Innovative strategies paving the way for enhanced data quality, integrity and streamlined data validation and cleaning. The way we clean and validate data within clinical trials is continuously evolving, more than ever now with the advancements in technology that we are seeing across this industry year on year. These technological developments are reshaping the way data is handled, leading to improvements in the accuracy and efficiency of data.

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Lilly hikes revenue forecast by $2B as GLP-1 drug sales climb

BioPharma Drive: Drug Pricing

Supply continues to be tight, however, and the company anticipates further sales growth to be limited by how quickly it can bring on additional production capacity.

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MRNA Vaccine Fights Deadly Brain Tumor in Small Trial

Drugs.com

THURSDAY, May 2, 2024 -- An experimental cancer vaccine can quickly reprogram a person’s immune system to attack glioblastoma, the most aggressive and lethal form of brain cancer, a small, preliminary study has found.The cancer vaccine is based.

Vaccine 105
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Researchers identify over 2,000 genetic signals linked to blood pressure in study of over one million people

Science Daily: Pharmacology News

Researchers have discovered over a hundred new regions of the human genome, also known as genomic loci, that appear to influence a person's blood pressure. In total, over 2,000 independent genetic signals for blood pressure are now reported, demonstrating that blood pressure is a highly complex trait influenced by thousands of different genetic variants.

Research 129
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Balancing Work and Home Life: 4 Ways to Support Better Mental Health for Mothers

Perficient: Drug Development

I recently became a mother for the third time, welcoming a beautiful baby girl in July 2023. Stepping into the whirlwind of newborn life with two other children in tow felt like diving headfirst into uncharted waters! Balancing the needs of three young humans has become my daily adventure, filled with equal parts chaos and love. Mo therhood , whether it’s the first or fifth time, is a beautiful yet wildly demanding journey that nearly always involves juggling multiple responsibilities simultane

Nurses 98
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FTC targets ‘junk patents’ on Ozempic, other top drugs

BioPharma Drive: Drug Pricing

The move broadens the antitrust regulator’s campaign against allegedly “improper or inaccurate” patent listings by drugmakers to include top-selling medicines for weight loss, diabetes, asthma and COPD.

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Another Teen Vaping Danger: Toxic Lead, Uranium

Drugs.com

TUESDAY, April 30, 2023 -- Teens who vape frequently are exposing themselves to harmful metals like lead and uranium, a new study finds.Lead levels in urine are 40% higher among intermittent vapers and 30% higher among frequent vapers, compared to.

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Marriage of synthetic biology and 3D printing produces programmable living materials

Science Daily: Pharmacology News

Scientists are harnessing cells to make new types of materials that can grow, repair themselves and even respond to their environment. These solid 'engineered living materials' are made by embedding cells in an inanimate matrix that's formed in a desired shape. Now, researchers have 3D printed a bioink containing plant cells that were then genetically modified, producing programmable materials.

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Science show’s speakers bring star power to the lab

Drug Discovery Today

The SLS Show and Conference will feature huge names in science media

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