Drug Hunter

JUNE 5, 2023

Interestingly, among the six case studies, none use the well-known Hoveyda-Grubbs II (HG-II) catalyst in the largest scale synthesis disclosed, though several employ HG-II derivatives, highlighting the rapid evolution of catalytic methods and distinct considerations for process chemistry. Gonzalez-Bobes, F. 2023 , 66 , (8), 5377-5396.

Process Chemistry 206

Process Chemistry Drugs Production Clinical Development 206

Fierce BioTech

JULY 27, 2023

Process Chemistry Unleashed: A 'Fit-for-Purpose' Approach to Accelerate IND Filing pesurya Thu, 07/27/2023 - 11:27 Tue, 09/05/2023 - 10:00 Resource Type Webinar Qixuan Lu Duration 60 Minutes Process chemistry plays a pivotal role in various stages of the pharmaceutical R&D cycle.

Process Chemistry 52

Process Chemistry Compliance FDA Drug Development 52

Fierce BioTech

MAY 21, 2025

However, when medicinal and process chemistry teams collaborate toward a shared goal of accelerating early-phase development for IND filing, these challenges can be systematically addressed. These hurdles can delay the delivery of toxicology and clinical batches of the API, leading to costly setbacks for drug developers.

Process Chemistry 52

Process Chemistry Compliance Drug Development Drugs 52

Sygnature Discovery

JANUARY 26, 2024

For instance, small scale batches from chiral SFC might be amorphous and dissolve readily, but process chemistry and scale-up could produce a crystalline form, affecting solubility and in vivo performance. Understanding the solid form properties of a material can significantly impact other studies.

Process Chemistry 52

Process Chemistry 52

Sygnature Discovery

MAY 17, 2024

For instance, small scale batches from chiral SFC might be amorphous and dissolve readily, but process chemistry and scale-up could produce a crystalline form, affecting solubility and in vivo performance. Understanding the solid form properties of a material can significantly impact other studies.

Process Chemistry 52

Process Chemistry 52

Sygnature Discovery

JANUARY 26, 2024

Working closely with our colleagues in Process Chemistry and Scale-Up, Drug Metabolism and Pharmacokinetics (DMPK), Pharmacology, and Separation Science, we can apply the right tools to solve the most complex challenges in your project. This approach helps to overcome even the most complex bioavailability or stability challenges.

Process Chemistry 52

Process Chemistry Pharmacokinetics Clinical Development Laboratories 52

The Open Targets Blog

SEPTEMBER 21, 2023

This involves scaling up the process of making a few grams of the compound in the lab to hundreds of tonnes in a factory, in an environmentally-friendly, cost-effective way. Process chemistry is incredibly multidisciplinary: in addition to chemists, you need analytical teams to make sure everything is 99.9%

Organic Chemistry 82

Organic Chemistry Process Chemistry Small Molecule Science 82