article thumbnail

Macrocyclization via Ring-Closing Metathesis in Drug Discovery & Process Chemistry

Drug Hunter

Interestingly, among the six case studies, none use the well-known Hoveyda-Grubbs II (HG-II) catalyst in the largest scale synthesis disclosed, though several employ HG-II derivatives, highlighting the rapid evolution of catalytic methods and distinct considerations for process chemistry. Gonzalez-Bobes, F. 2023 , 66 , (8), 5377-5396.

article thumbnail

Process Chemistry Unleashed: A 'Fit-for-Purpose' Approach to Accelerate IND Filing

Fierce BioTech

Process Chemistry Unleashed: A 'Fit-for-Purpose' Approach to Accelerate IND Filing pesurya Thu, 07/27/2023 - 11:27 Tue, 09/05/2023 - 10:00 Resource Type Webinar Qixuan Lu Duration 60 Minutes Process chemistry plays a pivotal role in various stages of the pharmaceutical R&D cycle.

Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

article thumbnail

Optimizing Protocols to Seamlessly Transfer Med. Chem. Synthesis to Process Development

Fierce BioTech

However, when medicinal and process chemistry teams collaborate toward a shared goal of accelerating early-phase development for IND filing, these challenges can be systematically addressed. These hurdles can delay the delivery of toxicology and clinical batches of the API, leading to costly setbacks for drug developers.

article thumbnail

Solid Form Analysis

Sygnature Discovery

For instance, small scale batches from chiral SFC might be amorphous and dissolve readily, but process chemistry and scale-up could produce a crystalline form, affecting solubility and in vivo performance. Understanding the solid form properties of a material can significantly impact other studies.

article thumbnail

Solid Form Analysis

Sygnature Discovery

For instance, small scale batches from chiral SFC might be amorphous and dissolve readily, but process chemistry and scale-up could produce a crystalline form, affecting solubility and in vivo performance. Understanding the solid form properties of a material can significantly impact other studies.

article thumbnail

Form and Formulation

Sygnature Discovery

Working closely with our colleagues in Process Chemistry and Scale-Up, Drug Metabolism and Pharmacokinetics (DMPK), Pharmacology, and Separation Science, we can apply the right tools to solve the most complex challenges in your project. This approach helps to overcome even the most complex bioavailability or stability challenges.

article thumbnail

Welcome to new Director David Hulcoop

The Open Targets Blog

This involves scaling up the process of making a few grams of the compound in the lab to hundreds of tonnes in a factory, in an environmentally-friendly, cost-effective way. Process chemistry is incredibly multidisciplinary: in addition to chemists, you need analytical teams to make sure everything is 99.9%