Drug Target Review

NOVEMBER 13, 2023

The instructions to form a cell are encoded in DNA strands, wrapped in proteins and RNA, and wound together into a 3D structure called chromatin. Nature reviews immunology [Internet] 2008 July [2023 November 10]; 8:523-32. It is challenging to change a cell’s identity, even from an infection-fighting T cell to a regulatory T cell.

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Government DNA RNA Regulations 105

Codon

JUNE 11, 2024

Their solution was to fuse hairpins, little loops made from RNA or DNA, at various positions along the DNA strand that was being sequenced. But in 2008 , physicists at the University of Washington made a nanopore sequencer using a protein, called MspA, from Mycobacterium smegmatis, a bacterium first described in the 1880s.

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DNA Engineering RNA Small Molecule 97

Drug Target Review

MARCH 21, 2024

There are a few approved therapies for DMD including four exon-skipping drugs and one AAV-microdystrophin drug, which uses a shortened version of dystrophin. AAV-based therapies often can’t be dosed more than once due to concerns about an immune response. Of note, mRNA is redosable as opposed to AAV. Human molecular genetics.

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Therapies RNA Immune Response Treatment 65

Elrig

MARCH 10, 2025

The free-to-attend event will bring together scientists, researchers and entrepreneurs from across the drug discovery community working on proteins, RNA, cell and gene therapies, PROTACs, as well as the application of big data to support target identification, biomarkers and the development of big molecules.

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Research Laboratories Medical Schools Engineering 52

Drug Target Review

NOVEMBER 27, 2024

As precision medicines, including RNA interference (RNAi) and oligonucleotide therapies, become more prominent, the importance of advanced techniques in streamlining biomarker validation and expediting the regulatory review process becomes even clearer. 2008 Aug 1;63(8):879–84. Food and Drug Administration.

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Drug Development Regulations Laboratories FDA 52

Codon

AUGUST 10, 2023

Nature Reviews Molecular Cell Biology (2008). Drug Discovery Today: Disease Models (2008). Link A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity , by Jinek M. Molecular Systems Biology (2008). Link Modelling and analysis of gene regulatory networks , by Karlebach G. & et al. . &

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DNA Cell Biology Molecular Biology Engineering 98

Codon

APRIL 28, 2025

While initially overlooked, GFP later revolutionized biology and medicine, earning Shimomura a share of the 2008 Nobel Prize in Chemistry. Each cell contains messenger RNA (mRNA) that carries instructions for making proteins, so Prasher first extracted mRNA from Aequorea and converted it into complementary DNA (cDNA).

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DNA Engineering Research Virus 77