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The rising impact of biomarkers in early clinical development

Drug Target Review

Haemoglobin A1c (HbA1c) is a validated surrogate endpoint for the reduction of microvascular complications associated with diabetes mellitus; reduced HIV-RNA levels serve as an endpoint for HIV disease control; and a reduction in low-density lipoprotein (LDL) cholesterol is used as an endpoint indicating lower likelihood of cardiovascular events.

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Therapeutic Oligos 2025 Keynote Speakers Announced

Elrig

This second ELRIG meeting on Therapeutic Oligonucleotides brings together esteemed scientists from academia, industry, and other members of the drug discovery community to explore the discovery, validation, and targeting of oligonucleotide-based drug candidates, including antisense oligonucleotides (ASOs) and small interfering RNA (siRNA).

RNA 59
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Looking beyond traditional oncogenic pathways to break cancer resistance

Drug Target Review

Analysis of transcriptional changes using RNA sequencing further confirmed that TT125-802 suppresses key non-oncogene resistance mechanisms including transcriptional networks around stemness, epithelial-mesenchymal transition (EMT), and transforming growth factor beta (TGFβ) signalling. Available from: [link] 8.Boni

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SRP-001: redefining pain treatment with a safer, non-opioid analgesic

Drug Target Review

Using the 10X Genomics Chromium platform, we conducted ribonucleic acid (RNA) sequencing on the midbrain’s PAG region in animals treated with SRP-001, ApAP and a vehicle control, focusing on gene expression changes related to pain processing. was founded in 2016 to develop safer, non-opioid therapies for acute and chronic pain.

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TACACICLIB, AUR-102, AURIGENE

New Drug Approvals

As a TFIIH subunit, CDK7 phosphorylates the CTD (Carboxy-Terminal-Domain) of the largest subunit of RNA polymerase II (pol II). In addition to CDK7, other CDKs have been reported to phosphorylate and regulate RNA pol (II) CTD. 13, 261-91, 1997). 1004-1014, 2004). Oct 1 5;24(20):2303-16, 2010; Blazek et al.,

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ATUZAGINSTAT

New Drug Approvals

In addition, older dogs had bacterial antigens and ribosomal RNA in their brains, consistent with systemic infection seen in humans. The pharmacokinetic profiles of COR388 in AD and controls were reported to be similar. Findings Two Phase 1 trials of atuzaginstat were completed by June 2019. All volunteers with AD had P. mmol, 1.00