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From siloed data to breakthroughs: multimodal AI in drug discovery

Drug Target Review

Unimodality does not allow for mixing data: cell data, images, molecular data, clinical data records, small molecule descriptors, ADME Tox data, transcriptomic data, text-based drug and disease representations, clinical trial protocols, publications and patent data, etc.

Drugs 64
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Reaching cruising altitude: New discovery tools to target RNA

Dark Matter Blog

The majority of small molecule drugs induce their therapeutic effects by seeking out and binding to their intended target while avoiding most other molecules in the dense milieu of the cell interior. Our overall mission at Arrakis is to expand the set of “druggable” targets for small-molecule medicines to include RNA.

RNA 52
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AI in Drug Discovery - A Highly Opinionated Literature Review (Part II)

Practical Cheminformatics

No member company will agree to use a representation that can potentially be reverse-engineered to reveal the chemical structures of its molecules. In each example, the authors use a modified version of their open source package MolPAL to design molecules with a specified selectivity profile.

Drugs 136
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AI At The Frontier: Empowering Early Career Professionals In Drug Discovery

Elrig

With a background in Bioinformatics and Computational Biology, she has a keen interest in using technology to solve problems in healthcare and medicine. There, I supported AI-enabled DD efforts in their small molecule portfolio. Bioinformatics is all about bringing together different areas of knowledge.

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AI-driven drug discovery: insights from Cresset

Drug Target Review

Cresset delivers software solutions and contract research expertise enabling companies around the world to accelerate their small molecule discovery processes efficiently and effectively. He also held a genomics consultancy role and worked as an R&D engineer in the speech-to-text domain at Hewlett Packard.

Drugs 64
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Codon Digest: GPT-4 Controls a Robot

Codon

Codon Digest is my weekly roundup of research, news, and industry highlights about engineered biology. These microbes were engineered to express tumor antigens that could “elicit T cells that were licensed by the commensal immune program but specific for a tumor,” including both CD4+ and CD8+ T cells, according to the study.

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Early evidence and emerging trends: How AI is shaping drug discovery and clinical development

Drug Target Review

Traditional drugs for eye diseases like glaucoma are small molecules delivered by simple eye drops. His leadership has driven international commercial success in areas including image analysis, data management, bioinformatics, advanced clinical trial data analysis leveraging machine learning and federated learning.