This site uses cookies to improve your experience. To help us insure we adhere to various privacy regulations, please select your country/region of residence. If you do not select a country, we will assume you are from the United States. Select your Cookie Settings or view our Privacy Policy and Terms of Use.
Cookie Settings
Cookies and similar technologies are used on this website for proper function of the website, for tracking performance analytics and for marketing purposes. We and some of our third-party providers may use cookie data for various purposes. Please review the cookie settings below and choose your preference.
Used for the proper function of the website
Used for monitoring website traffic and interactions
Cookie Settings
Cookies and similar technologies are used on this website for proper function of the website, for tracking performance analytics and for marketing purposes. We and some of our third-party providers may use cookie data for various purposes. Please review the cookie settings below and choose your preference.
Strictly Necessary: Used for the proper function of the website
Performance/Analytics: Used for monitoring website traffic and interactions
Unimodality does not allow for mixing data: cell data, images, molecular data, clinical data records, smallmolecule descriptors, ADME Tox data, transcriptomic data, text-based drug and disease representations, clinical trial protocols, publications and patent data, etc.
The majority of smallmolecule drugs induce their therapeutic effects by seeking out and binding to their intended target while avoiding most other molecules in the dense milieu of the cell interior. Our overall mission at Arrakis is to expand the set of “druggable” targets for small-molecule medicines to include RNA.
No member company will agree to use a representation that can potentially be reverse-engineered to reveal the chemical structures of its molecules. In each example, the authors use a modified version of their open source package MolPAL to design molecules with a specified selectivity profile.
With a background in Bioinformatics and Computational Biology, she has a keen interest in using technology to solve problems in healthcare and medicine. There, I supported AI-enabled DD efforts in their smallmolecule portfolio. Bioinformatics is all about bringing together different areas of knowledge.
Cresset delivers software solutions and contract research expertise enabling companies around the world to accelerate their smallmolecule discovery processes efficiently and effectively. He also held a genomics consultancy role and worked as an R&D engineer in the speech-to-text domain at Hewlett Packard.
Codon Digest is my weekly roundup of research, news, and industry highlights about engineered biology. These microbes were engineered to express tumor antigens that could “elicit T cells that were licensed by the commensal immune program but specific for a tumor,” including both CD4+ and CD8+ T cells, according to the study.
Traditional drugs for eye diseases like glaucoma are smallmolecules delivered by simple eye drops. His leadership has driven international commercial success in areas including image analysis, data management, bioinformatics, advanced clinical trial data analysis leveraging machine learning and federated learning.
Drugs that were developed and commercialised 30+ years ago were relatively simple smallmolecules. Todays smallmolecules are far larger, more complex, and chase highly specific (and difficult to hit) targets, thereby increasing the chances of undesired side effects. This failure is getting more pronounced by the day.
We organize all of the trending information in your field so you don't have to. Join 15,000+ users and stay up to date on the latest articles your peers are reading.
You know about us, now we want to get to know you!
Let's personalize your content
Let's get even more personalized
We recognize your account from another site in our network, please click 'Send Email' below to continue with verifying your account and setting a password.
Let's personalize your content