Drug Target Review

OCTOBER 16, 2023

Two-dimensional cell models were the cornerstone of cellular assays in early drug discovery for years, yet the system lacks the genetic and epigenetic background of the patient and the cell-to-cell spatial architecture and cellular signalling between cells of different types within the tissue architecture.

Disease 122

Disease Immune Response Cell Biology Treatment 122

Drug Target Review

NOVEMBER 17, 2023

NK cells are among the front line of protection from infected and abnormal cells as part of the ‘innate immune response’. They recognise ‘cell stress molecules’ on the surface of infected, old, injured and cancerous cells without the need for complex pre-stimulation signals of the adaptive immune system (eg, T cells).

Therapies 118

Therapies Clinical Trials Cell Biology Trials 118

Broad Institute

MAY 21, 2025

In the 1990s, Michel Sadelain then at Memorial Sloan Kettering Cancer Center (MSKCC) designed CARs by combining fragments of tumor-recognizing antibodies with the molecular machinery found in T-cell receptors. Sadelain and Rivire also developed safe and reliable ways to produce these cells for use in patients.

Therapies 119

Therapies FDA Approval Engineering Immune Response 119

Broad Institute

OCTOBER 11, 2023

By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cell biology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer. They are used to treat cancers including melanoma and non-small cell lung cancer, but work only for a small fraction of patients. “We

Research 137

Research Immune Response Clinical Trials Therapies 137

Drug Target Review

OCTOBER 2, 2024

The heart does have limited regenerative capacity, but not enough of the healthy cells that capable of restoring function, making it difficult to recover from injuries such as myocardial infarction. However, cell-based therapies are intended to leverage those healthy cells via transplant to regenerate damaged tissue.

Therapies 98

Therapies Disease RNA Engineering 98

Codon

APRIL 30, 2023

Read more at Nature Biotechnology ( Similar paper at Nature Biomedical Engineering.) How to make a cell-penetrating Cas9 protein, and then incubate it with peptides to edit human cells. 2/ Live Long and Prosper, Lil’ Yeasty Boys Yeast cells usually live for about one week. Nature Biomedical Engineering.

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

APRIL 30, 2023

Read more at Nature Biotechnology ( Similar paper at Nature Biomedical Engineering.) How to make a cell-penetrating Cas9 protein, and then incubate it with peptides to edit human cells. 2/ Live Long and Prosper, Lil’ Yeasty Boys Yeast cells usually live for about one week. Nature Biomedical Engineering.

Vaccine 52

Vaccine DNA Engineering RNA 52