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Unlocking Undruggable Targets: Shifting Paradigms in Modern Drug Discovery

DrugBank

But as molecular biology has advanced, so too has our approach to finding new drugs. Today, we're able to identify and target specific molecules involved in disease processes—a method that's much more like using a sniper rifle than throwing darts blindfolded. This method was more about serendipity than science.

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Medicinal Chemistry In The Age Of Artificial Intelligence

LifeSciVC

The genomic capabilities that were brought online for drug discovery (cheaper & faster next-gen DNA sequencing) did not diminish the need for biologists and translational scientists in target and patient selection, respectively. One final parallel to 2001.

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Phages could help to tackle antimicrobial resistance

Drug Target Review

Phage have been of interest to scientists as tools to understand fundamental molecular biology, as vectors of horizontal gene transfer and drivers of bacterial evolution, as sources of diagnostic and genetic tools, and as novel therapeutic agents. Its presence elsewhere would indicate something is wrong. But what, exactly?”

RNA 59
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The evolution of cell therapy to address unmet medical needs

Drug Target Review

The other powerful benefit is that our cell lines can become any of the cell types of the human body – these cells have within their DNA the capability to become any of the more than 200 human cell types which you might want to manufacture. Just like small molecules and antibodies, cell therapies are changing how we treat patients.

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A Look Back

Dark Matter Blog

The only subject in school that held my interest was biology. As soon as I learned about DNA and RNA, I wanted to be a molecular biologist. I wanted to use molecular biology to create drugs. Last stops at RNA My last roles in biotech were where my original passion began: DNA and RNA.

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AI At The Frontier: Empowering Early Career Professionals In Drug Discovery

Elrig

Srinivasan has led the development of multiple computational pipelines to process data from different next generation sequencing techniques with applications in oncology, genome editing systems including CRISPR-Cas mediated DNA editing, and ADAR-mediated RNA editing. There, I supported AI-enabled DD efforts in their small molecule portfolio.

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Toxic Proteins for Drug Discovery

Codon

While small-molecule drugs continue to play a critical role in modern medicine, we are witnessing a shift toward the increasing development of amino acid-based therapeutics. This is the step after the initial transcription of DNA into mRNA by RNA Polymerase II, the protein to which alpha amanitin binds.

Drugs 106