Covalent Modifiers

APRIL 9, 2025

Dennis H. Kim and Watson J. Lees Biochemistry 2025 DOI: 10.1021/acs.biochem.4c00522 The antibiotic fosfomycin is an epoxy-phosphonate natural product with a broad spectrum of antibacterial activity and distinct mechanism of action that has been in clinical use for 50 years. Fosfomycin is an irreversible covalent inhibitor of UDP-GlcNAc enolpyruvyl transferase (MurA), which catalyzes the first committed step in bacterial peptidoglycan biosynthesis.

Production

Drug Patent Watch

APRIL 9, 2025

Patient-Centric Approaches to Maintaining Brand Value As the pharmaceutical industry continues to evolve, one thing remains clear: patients are at the forefront of every decision. At DrugPatentWatch, we've seen firsthand how patient-centric approaches can make all the difference in maintaining brand value. In our latest blog post, we explore the importance of putting patients first in brand strategy.

Pharmaceuticals

Science Daily: Pharmacology News

APRIL 9, 2025

Wear and tear on plastic products releases small to nearly invisible plastic particles, which could impact people's health when consumed or inhaled. To make these particles biodegradable, researchers created plastics from plant starch instead of petroleum. An initial study shows how animals consuming particles from this alternative material developed health problems such as liver damage and gut microbiome imbalances.

Production

Drug Patent Watch

APRIL 9, 2025

"Market Domination Through Cost Optimization: A Game-Changer for Generic Drug Manufacturers As the pharmaceutical industry continues to evolve, generic drug manufacturers are facing increasing pressure to reduce production costs while maintaining quality and regulatory compliance. At DrugPatentWatch, we've identified key strategies to help generic drug manufacturers optimize their production costs and gain a competitive edge in the market.

Production

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

Clinical Trials

Drug Channels

APRIL 9, 2025

It's time for Drug Channels annual update of vertical integration among insurers, PBMs, specialty pharmacies, and healthcare services within U.S. drug channels. As you can see below, we have revised, renovated, and refurbished our infamous illustration of the major vertical business relationships among the largest companies. Proponents of these vertical integration arrangements argue that they create opportunities to mine healthcare costs.

Specialty Pharmacies

Drug Patent Watch

APRIL 9, 2025

Just spent the day diving into the world of biosimilars and regulatory considerations. Key takeaways from the article on DrugPatentWatch: Biosimilar extrapolation of indications is a complex process that requires a deep understanding of the regulatory landscape. The FDA has established a framework for evaluating biosimilarity, but there is still a lack of clarity around extrapolation.

Biosimilars

Drug Patent Watch

APRIL 9, 2025

"Unlocking New Hope for Neurological Disorders As we continue to push the boundaries of medical innovation, I'm excited to share with you a game-changing development in the fight against neurological disorders. At the forefront of this revolution is AI-based drug repurposing. By leveraging cutting-edge technology, researchers are re-examining existing medications to identify new uses for treating conditions such as Alzheimer's, Parkinson's, and multiple sclerosis.

Clinical Trials

Science Daily: Pharmacology News

APRIL 9, 2025

Heavy drinkers who have eight or more alcoholic drinks per week have an increased risk of brain lesions called hyaline arteriolosclerosis, signs of brain injury that are associated with memory and thinking problems, according to a new study.

Drugs.com

APRIL 9, 2025

WEDNESDAY, April 9, 2025 -- An experimental drug can help patients with advanced multiple sclerosis (MS) delay the progressive disability that comes with their disorder, a new clinical trial suggests.The drug, tolebrutinib, delayed disability.

Clinical Trials

Science Daily: Pharmacology News

APRIL 9, 2025

From a tiny sample of tissue no larger than a grain of sand, scientists have come within reach of a goal once thought unattainable: building a complete functional wiring diagram of a portion of the brain.

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Drugs.com

APRIL 9, 2025

WEDNESDAY, April 9, 2025 -- Americas emergency rooms are near the breaking point, causing long wait times and boarding of patients awaiting care, a new study says.Essentially, ERs are being asked to serve as health care hubs that offer services f.

Science Daily: Pharmacology News

APRIL 9, 2025

Evidence shows that hunter-gatherers were crossing at least 100 kilometers (km) of open water to reach the Mediterranean island of Malta 8,500 years ago, a thousand years before the arrival of the first farmers.

Drugs.com

APRIL 9, 2025

WEDNESDAY, April 9, 2025 -- Food additive mixtures commonly found in diet drinks, soups, dairy desserts and sauces may slightly increase a persons risk of type 2 diabetes, a new study says.A mixture of additives commonly found in artificially s.

Science Daily: Pharmacology News

APRIL 9, 2025

Astronomers have peered back in time to find what looks like a population of 'hidden' galaxies that could hold the key to unlocking some of the universe's secrets. If their existence is confirmed it would 'effectively break current models of galaxy numbers and evolution'. The possible galaxies may also provide the missing piece of the puzzle for the energy generation in the universe in infrared light.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drugs.com

APRIL 9, 2025

WEDNESDAY, April 9, 2025 -- In an effort to address high maternal and infant mortality rates plaguing many of the Southern U.S. states, legislators in Alabama have passed a bill that will allow Medicaid to be more easily accessible for pregnant.

Science Daily: Pharmacology News

APRIL 9, 2025

In a cave overlooking the ocean on the southern coast of South Africa, archaeologists discovered thousands of stone tools, created by ancient humans roughly 20,000 years ago. By examining tiny details in the chipped edges of the blades and stones, archaeologists are able to tell how the tools were made -- which revealed that people were sharing crafting techniques over wide distances.

BioPharma Drive: Drug Pricing

APRIL 9, 2025

In its first full year on the U.S. market, bladder cancer treatment Adstiladrin earned about $77 million. Elsewhere, Lilly backed a cancer drug startup and Bristol Myers won a new Opdivo approval.

Therapies

Science Daily: Pharmacology News

APRIL 9, 2025

Engineers have hit the trifecta of sustainability technology: A group has developed a low-cost method to produce carbon-free 'green' hydrogen via solar-powered electrolysis of seawater. A happy byproduct of the process? Potable water.

Engineering

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

APRIL 9, 2025

WEDNESDAY, April 9, 2025 -- Folks with low back pain can use their minds to effectively cope with their suffering, a new clinical trial says.Mindfulness meditation and cognitive-behavioral therapy (CBT) both significantly reduced pain among people.

Clinical Trials

Science Daily: Pharmacology News

APRIL 9, 2025

FLUID, an open-source, 3D-printed robot, offers an affordable and customizable solution for automated material synthesis, making advanced research accessible to more scientists.

Research

Drugs.com

APRIL 9, 2025

WEDNESDAY, April 9, 2025 -- People with heart implants could be in trouble if theyre hit with a powerful handheld taser, a new study says.A heavy electrical charge delivered by a taser could cause a pacemaker or implanted defibrillator to m.

Science Daily: Pharmacology News

APRIL 9, 2025

Rhinos that flourished across much of North America 12 million years ago gathered in huge herds, according to a new study.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

APRIL 9, 2025

WEDNESDAY, April 9, 2025 -- Brain diseases like stroke, dementia and depression share common risk factors, and changing any can lower a persons risk of all three conditions, a new study says.Addressing factors as varied as blood pressure, blood s.

Disease

Science Daily: Pharmacology News

APRIL 9, 2025

Rsearchers have developed the first wearable device for measuring gases emitted from and absorbed by the skin. By analyzing these gases, the device offers an entirely new way to assess skin health, including monitoring wounds, detecting skin infections, tracking hydration levels, quantifying exposure to harmful environmental chemicals and more.

Drugs.com

APRIL 9, 2025

WEDNESDAY, April 9, 2025 -- A health care program focused on suicide prevention has helped lower suicides and attempts, a new study shows.The program, called the "Zero Suicide Model," relies on screening, safety planning and mental health support.

Science Daily: Pharmacology News

APRIL 9, 2025

Researchers have discovered a way to get anti-inflammatory medicine across the blood-brain barrier, opening the door to potential new therapies for a range of conditions, including Alzheimer's disease, multiple sclerosis, Parkinson's disease and cancer cachexia.

Treatment

Broad Institute

APRIL 9, 2025

Diffusion for molecule generation/Structured variational autoencoders for prediction and optimization By Rose Circeo April 9, 2025 Breadcrumb Home Diffusion for molecule generation/Structured variational autoencoders for prediction and optimization Alexandru Dumitrescu Aalto University Dani Korpela Aalto University Primer: Diffusion for molecule generation In silico molecule generation enables the rapid creation of an initial pool of drug-like molecules, potentially accelerating significantly dr

Drugs

Science Daily: Pharmacology News

APRIL 9, 2025

A medical breakthrough could result in the first treatment for rare but serious diseases in which genetic defects disrupt cellular energy production. Researchers have identified a molecule that helps more mitochondria function properly.

Treatment

BioPharma Drive: Drug Pricing

APRIL 9, 2025

Shares in many large drugmakers fell Wednesday on the president's threat, which could further challenge an already battered sector.

Pharmaceuticals

Science Daily: Pharmacology News

APRIL 9, 2025

Research into transcription factors deepen understanding of the 'language' of the genome, offering insights into human development.

Research

Drugs.com

APRIL 9, 2025

WEDNESDAY, April 9, 2025 -- The Trump administration has let go of the last remaining U.S. health officials who oversaw HIV care for more than 1.1 million mothers and children in low-income countries.The move raises alarms about how these.

Science Daily: Pharmacology News

APRIL 9, 2025

A new study reveals the modern arid desert between Africa and Saudi Arabia was once regularly lush and green with rivers and lakes over a period of 8 million years, allowing for the occupation and movements of both animals and hominins.