Thu.Mar 20, 2025

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Plop.js – A micro-generator framework: Template Creation (Part-2)

Perficient: Drug Development

Continuing Our Plop.js Journey from last blog In our previous discussion, we explored an introduction to Plop.js and its installation in a Next.js project. Additionally, we looked at a basic skeleton of plopfile.js. Understanding the Components of plopfile.js As we saw earlier, the plopfile.js consists of key elements that define the generator. Lets break them down again for clarity: The setGenerator creates a generator of the plop.

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Strategies for effective biosimilar regulatory agency interactions

Drug Patent Watch

Navigating the Complex World of Biosimilar Regulatory Agency Interactions As a biosimilar developer, you know that getting your product to market can be a long and arduous process. One of the most critical components of this journey is interacting with regulatory agencies. But how can you ensure that these interactions are effective and set your product up for success?

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Plop.js – A micro-generator framework: Introduction and Installation (Part-1)

Perficient: Drug Development

We all may have come across this situation countless times in our projectscopying and pasting files just to create a new component, page, or service. Unfortunately, this slows us down and hampers our productivity by introducing errors into the workflow. However, there’s a solution! Plop.js is the answer to this problem, as it automates these tasks and allows us to focus on writing great code.

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The Advantages of Using a CDMO

Drug Patent Watch

Unlock the Full Potential of Your Pharmaceutical Product: The Power of a CDMO As a pharmaceutical professional, you're constantly looking for ways to bring innovative products to market faster and more efficiently. One key strategy that can help you achieve this goal is partnering with a Contract Development and Manufacturing Organization (CDMO). But what exactly is a CDMO, and how can it benefit your business?

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Bring Your Own Device (BYOD) Clinical Trials: How They Transform Decentralized Data Capture

Crucial Data Solutions

What Is BYOD in Clinical Trials? Bring Your Own Device (BYOD) is changing the way clinical trials collect and manage. The post Bring Your Own Device (BYOD) Clinical Trials: How They Transform Decentralized Data Capture appeared first on Crucial Data Solutions.

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New DESI results strengthen hints that dark energy may evolve

Science Daily: Pharmacology News

The Dark Energy Spectroscopic Instrument used millions of galaxies and quasars to build the largest 3D map of our universe to date. Combining their data with other experiments shows signs that the impact of dark energy may be weakening over time -- and the standard model of how the universe works may need an update.

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Galapagos birds exhibit 'road rage' due to noise

Science Daily: Pharmacology News

A new study has discovered that birds in the Galapagos Islands are changing their behavior due to traffic noise, with those frequently exposed to vehicles showing heightened levels of aggression. During trials involving traffic noise, Galapagos yellow warblers (Setophaga petechia aureola) increased the duration of their songs, increased the minimum frequencies of their songs (to reduce overlap with the traffic noise), and birds living close to roads displayed increased physical aggression.

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Clot-Busting Drug, TNKase, Quicker And As Effective In Treating Stroke

Drugs.com

THURSDAY, March 20, 2025 -- A newly approved clot- busting drug for stroke works as well as a decades-old medication still used by most U.S. hospitals, and can be delivered even more quickly, a new study says. Tenecteplase (TNKase) is the first new.

Hospitals 204
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Insomniac fruit fly mutants show enhanced memory despite severe sleep loss

Science Daily: Pharmacology News

Fruit fly mutants that have severe sleep deficits perform better at olfactory learning and memory tasks, according to a new study. The paradox of enhanced memory despite sleep loss could be explained by protein kinase A (PKA) signaling in the mushroom body of the fly brain.

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ADHD Misinformation Rampant On TikTok

Drugs.com

THURSDAY, March 20, 2025 -- TikToks most popular videos on ADHD are as likely to misinform viewers as they are to provide helpful hints, a new study says.More than half the claims made in the 100 most-viewed TikTok videos about a.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Oxygen discovered in most distant known galaxy

Science Daily: Pharmacology News

Astronomers have detected oxygen in the most distant known galaxy, JADES-GS-z14-0. This record-breaking detection is making astronomers rethink how quickly galaxies formed in the early Universe.

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Novartis builds case for new SMA gene therapy

BioPharma Drive: Drug Pricing

To Novartis, fresh late-stage data support the idea that its intrathecal drug, which has the same active ingredient as Zolgensma, could be approved for a broad range of spinal muscular atrophy patients.

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Another Raw Pet Food Recalled After Bird Flu Sickens Two Cats

Drugs.com

THURSDAY, March 20, 2025 -- A California pet food company has recalled raw chicken products after they were linked to bird flu infections in two cats and suspected in a third in New York City. Savage Pet, based in El Cajon, California, recalled one.

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Sanofi wagers $600M on a dual-targeting antibody drug for autoimmune disease

BioPharma Drive: Drug Pricing

The deal with startup Dren Bio hands Sanofi a so-called myeloid cell engager that would compete with an array of programs aiming to “reset” the immune systems of people with inflammatory conditions.

Disease 177
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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New Clot-Busting Drug Quicker And As Effective In Treating Stroke

Drugs.com

THURSDAY, March 20, 2025 -- A newly approved clot- busting drug for stroke works as well as a decades-old medication still used by most U.S. hospitals, and can be delivered even more quickly, a new study says.Tenecteplase (TNKase) is the first new.

Hospitals 172
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New AI tool generates high-quality images faster than state-of-the-art approaches

Science Daily: Pharmacology News

Researchers developed a hybrid AI approach that can generate realistic images with the same or better quality than state-of-the-art diffusion models, but that runs about nine times faster and uses fewer computational resources. The tool uses an autoregressive model to quickly capture the big picture and then a small diffusion model to refine the details of the image.

Research 167
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Combination Therapy Recommended For Migraines

Drugs.com

THURSDAY, March 20, 2025 -- Doctors should prescribe triptans for migraine patients who arent receiving relief from over-the-counter (OTC) pain relievers, according to a new clinical guideline from the American College of Physicians.The r.

Therapies 158
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The cell's powerhouses: Molecular machines enable efficient energy production

Science Daily: Pharmacology News

Mitochondria are the powerhouses in our cells, producing the energy for all vital processes. Using cryo-electron tomography, researchers have now gained insight into the architecture of mitochondria at unprecedented resolution. They discovered that the proteins responsible for energy generation assemble into large 'supercomplexes', which play a crucial role in providing the cell's energy.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Dance Soothes Agitation In Alzheimer's Patients

Drugs.com

THURSDAY, March 20, 2025 -- Dancing is known to lift the spirit, and a new study shows that Alzheimers disease patients respond to the rhythmic moves as well.Dance classes eased agitation in a small group of people with Alzheimers disease and oth.

Disease 139
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Gene Therapy Studies and Germline Integration Assessment in Nonhuman Primates

Alta Sciences

Gene Therapy Studies and Germline Integration Assessment in Nonhuman Primates lperez Thu, 03/20/2025 - 22:44 Publication Poster_Altasciences_SOT_2025Gene_Therapy_Studies_and_Germline_Integration_Assessment_in_NHPs.

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Tonsil Removal Helps Kids With Snoring/Sleep Apnea

Drugs.com

THURSDAY, March 20, 2025 -- Removing the tonsils and adenoids can improve the sleep of kids with mild breathing problems that disturb their slumber, a new clinical trial reports.Children with sleep problems needed to see a doctor 32% less often and.

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Standardization and Harmonization of Altasciences Historical Control Database Development Using Certara SEND Explorer® for Integrated Toxicological Evaluation

Alta Sciences

Standardization and Harmonization of Altasciences Historical Control Database Development Using Certara SEND Explorer for Integrated Toxicological Evaluation lperez Thu, 03/20/2025 - 22:46 Publication Poster_Altasciences_SOT_2025Standardization_and_Harmonization_of_Altasciences_HCD.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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FDA Increases Testing For Heavy Metals In Baby Formula

Drugs.com

THURSDAY, March 20, 2025 -- The U.S. Food and Drug Administration (FDA) is stepping up testing for heavy metals in infant formula and reviewing key nutrients required in these products, federal health officials said. "The FDA will use all resources.

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Targeted Gene Therapy for CNS Disorders: Precision of Intra-Cerebroventricular (ICV) Delivery and Post-Administration Behavioral Assessments in Mice

Alta Sciences

Targeted Gene Therapy for CNS Disorders: Precision of Intra-Cerebroventricular (ICV) Delivery and Post-Administration Behavioral Assessments in Mice lperez Thu, 03/20/2025 - 22:48 Publication Poster_Altasciences_SOT_2025Targeted_Gene_Therapy_for_CNS_Disorders.

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Alnylam drug gets long-awaited FDA approval in deadly heart disease

BioPharma Drive: Drug Pricing

Amvuttra’s clearance in a rare form of cardiomyopathy could help Alnylam turn a regular profit — if it can wrest control of a competitive and fast-changing market.

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A 13-Week Dermal Toxicity Study of VIM-004 Gel, a STAR Particles Based Formulation in Göttingen Minipigs®

Alta Sciences

A 13-Week Dermal Toxicity Study of VIM-004 Gel, a STAR Particles Based Formulation in Gttingen Minipigs lperez Thu, 03/20/2025 - 22:49 Publication Poster_Altasciences_SOT_2025A_13-Week_Dermal_Toxicity_Study_in_Gottingen_Minipigs.

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Trump Administration May Cut CDC's HIV Prevention Division

Drugs.com

THURSDAY, March 20, 2025 -- The Trump administration is weighing elimination of the U.S. Centers for Disease Control and Preventions (CDC) Division on HIV Prevention, sparking concerns among public health experts.If implemented, the move could s.

Disease 197
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From dinosaurs to birds: the origins of feather formation

Science Daily: Pharmacology News

Feathers, essential for thermoregulation, flight, and communication in birds, originate from simple appendages known as proto-feathers, which were present in certain dinosaurs.By studying embryonic development of the chicken, researchers from the University of Geneva (UNIGE) have uncovered a key role of a molecular signalling pathway (the Shh pathway) in their formation.

Research 258
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Potential Role of Hesperidin in Improving Experimental Pulmonary Arterial Hypertension in Rats via Modulation of the NF‐κB Pathway

Chemical Biology and Drug Design

The figure illustrates the therapeutic effects of hesperidin on monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) in a rat model. Hesperidin improves PAH by reducing right ventricular systolic pressure, Fulton index, and mean pulmonary arterial pressure while increasing pulmonary artery velocity time integral and acceleration time. It also suppresses inflammation by inhibiting the NF-B pathway, leading to decreased expression of inflammatory cytokines and markers of vascular remo

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Why don't we remember being a baby? New study provides clues

Science Daily: Pharmacology News

Though we learn so much during our first years of life, we can't, as adults, remember specific events from that time. Researchers have long believed we don't hold onto these experiences because the part of the brain responsible for saving memories -- the hippocampus -- is still developing well into adolescence and just can't encode memories in our earliest years.

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The Biotech Juggling Act: Keeping all the Balls in the Air

LifeSciVC

When the going gets tough, the tough get going By Ram Aiyar, CEO of Korro Bio, as part of the From the Trenches feature of LifeSciVC. It has been quite a start to the 2025 year. The sentiment around biotech starting from the yearly JPM conference has been sour at best see post from Atlas Aimee Raleigh ( here ). Since then, sentiment has gotten progressively worse due to the many uncertainties that exist for investors.

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Novel memristors to overcome AI's 'catastrophic forgetting'

Science Daily: Pharmacology News

Memristors consume extremely little power and behave similarly to brain cells. Researchers have now introduced novel memristive that offer significant advantages: they are more robust, function across a wider voltage range, and can operate in both analog and digital modes. Their unique properties could help address the problem of 'catastrophic forgetting,' where artificial neural networks abruptly forget previously learned information.

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