Covalent Modifiers

OCTOBER 20, 2024

Bangyan Xu, Simon J. Mountford, Philip E. Thompson, and Laura E. Edgington-Mitchell ACS Omega 2024 DOI: 10.1021/acsomega.4c07604 Covalent activity-based probes are invaluable tools to monitor protease activity in vitro and in vivo. We recently discovered that dimethyl sulfoxonium ylides (SYs) bind selectively to cysteine cathepsin proteases in a mechanism-dependent manner.

147

147

Drugs.com

OCTOBER 20, 2024

SUNDAY, Oct. 20, 2024 -- Youth sports deliver all kinds of health benefits, both mental and physical, but young athletes can still get hurt.Every year, more than 3.5 million U.S. kids are treated for sports-related injuries. The most common.

130

130

Molecular Design

OCTOBER 20, 2024

Previous Next In an earlier post I considered what it might mean to describe drug design as AI-based. In this post I’ll take a general look at using machine learning (ML) to assess AI-generated chemical structures. Whether or not ML models ultimately prove to be fit for this purpose it is worth pointing out that many visionaries and thought leaders who tout computation as a panacea to humanity’s ills fail to recognize the complexity of biology (take a look at In The Pipeline posts from 2007 | 20

Metabolic Stability 84

Metabolic Stability Drugs Pharmaceuticals 84

Perficient: Drug Development

OCTOBER 20, 2024

Problem Statement: In Talend, while generating output file if we need to add a column as number or column name with space or to include any special characters as column name in Talend it won’t allow directly by adding the above-mentioned column names in schema, will get the below mentioned error. As number as column name: As space in column name: As special characters in column name: Solution: The above use case was implemented by simple Talend job and with the below steps.

52

52

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

Clinical Trials

FDA Law Blog: Biosimilars

OCTOBER 20, 2024

By Larry K. Houck — Eric Idle, as a body collector, immortalized the phrase, “Bring out your dead! Bring out your dead!” in the 1975 comedy classic, Monty Python and the Holy Grail. The Drug Enforcement Administration (“DEA”) would do well to update that phrase as “Bring out your meds! Bring out your meds!” to call attention to the 26th National Prescription Take Back Day.

Drugs 59

Drugs 59