Drugs.com
MAY 3, 2025
SATURDAY, May 3, 2025 Amyotrophic lateral sclerosis (ALS) known as Lou Gehrigs Disease based on the iconic 1930s New York Yankee baseball player is a progressive neurodegenerative disease that affects thousands of Americans every year. ALS re.
Chemical Biology and Drug Design
MAY 3, 2025
Osthole reduced YBX1 transcription by inhibiting MEF2A expression, thereby inactivating Wnt/-catenin signaling and inducing ferroptosis to alleviate liver fibrosis. ABSTRACT Liver fibrosis is pathologically associated with ferroptosis. Osthole (OST) has good therapeutic effects on liver fibrosis. Our study sought to investigate the pharmacological effects of OST on ferroptosis in hepatic stellate cells (HSCs) during the development of liver fibrosis and define the mechanisms involved.
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Chemical Biology and Drug Design
MAY 3, 2025
Design of ICOS/ICOS-L cyclic peptide inhibitor based on mimicking key interactions of ICOS-L with ICOS. ABSTRACT The interaction between the inducible T-cell costimulatory molecule (ICOS) and its ligand (ICOS-L) is a critical pathway in T-cell activation and immune regulation. We computationally designed a bicyclic peptide (CP5) that inhibits the ICOS/ICOS-L proteinprotein interaction (PPI).
Chemical Biology and Drug Design
MAY 3, 2025
ADSCs-EV transferred USP25 deubiquitinates and stabilizes SMAD7 expression in podocytes, thereby attenuating T2DM-induced kidney injury and podocyte apoptosis and inflammation. ABSTRACT Adipose tissue-derived mesenchymal stem cells (ADSCs) are identified to be potential therapeutic candidates for diabetic nephropathy (DN) through secreting exosomes (Exos).
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
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