Wed.Mar 26, 2025

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1,2,3‐Triazole Tethered Spiro[Indoline‐Oxirane] Derivatives Induce Anticancer Effects in Human Hepatoma Cells

Chemical Biology and Drug Design

Synthesis and anticancer studies of spiro[indoline-oxirane] derivatives. ABSTRACT Epoxides are well-known compounds as anticancer agents. In this article, we present the synthesis of novel 3-phenyl-1-((1-aryl-1 H -1,2,3-triazol-5-yl)methyl)spiro[indoline-3,2-oxiran]-2-one derivatives by the regioselective reaction of sulfur ylides with 1,2,3-triazole-tethered isatins and their anticancer effects on hepatocellular carcinoma (HCC) cells HepG2 and HCCLM3.

Research 100
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Repetitive behaviors and special interests are more indicative of an autism diagnosis than a lack of social skills

Science Daily: Pharmacology News

People with autism are typically diagnosed by clinical observation and assessment. To deconstruct the clinical decision process, which is often subjective and difficult to describe, researchers used a large language model (LLM) to synthesize the behaviors and observations that are most indicative of an autism diagnosis. Their results show that repetitive behaviors, special interests, and perception-based behaviors are most associated with an autism diagnosis.

Research 267
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Unlocking the Future of Enterprise AI: Databricks announces Anthropic Partnership

Perficient: Drug Development

The recent strategic partnership between Databricks and Anthropic is a big step forward for enabling enterprises to build, deploy, and govern AI agents that reason over proprietary data with accuracy, security, and governance. The landscape of enterprise AI is evolving rapidly, and we’re excited to share how our practice is positioned to help businesses maximize the potential of AI.

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Compliance Challenges in Generic Drug Development: Lessons Learned

Drug Patent Watch

The Unseen Hurdles of Generic Drug Development: Lessons Learned As the pharmaceutical industry continues to evolve, one thing remains constant: the pursuit of affordable, high-quality medications for patients worldwide. Generic drugs have long been a vital part of this equation, offering a more accessible alternative to brand-name medications. However, the journey to bringing a generic drug to market is often fraught with challenges.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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A cleaner future for tires: Scientists pioneer chemical process to repurpose rubber waste

Science Daily: Pharmacology News

Every year, millions of tires end up in landfills, creating an environmental crisis with far-reaching consequences. In the United States alone, over 274 million tires were scrapped in 2021, with nearly a fifth of them being discarded into landfills. A study has now pioneered a technique for breaking down this rubber waste and transforming it into valuable precursors for epoxy resins.

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Drug Channels News Roundup, March 2025: PBM Unbundling Update, Stelara Biosimilar Price War, My $0.02 on the Optum Rx News, Follow the Dollar, and #DCLF2025

Drug Channels

Spring has officially arrived in sunny downtown Philadelphiathe proud home base of Drug Channels. As you can see on the right, we celebrated in Miami at the Drug Channels Leadership Forum. The vernal equinox also brought a surprising surge of industry updates and noteworthy news you wont want to miss: Blue Shield of California provides a puzzling update to its PBM unbundling effort The Stelara biosimilar price war begins My reaction to Optum Rxs pharmacy reimbursement announcement A valuable Fol

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The devastating human impact on biodiversity

Science Daily: Pharmacology News

Humans are having a highly detrimental impact on biodiversity worldwide. Not only is the number of species declining, but the composition of species communities is also changing. This is one of the largest studies ever conducted on this topic.

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Wave to seek approval of Duchenne drug after mid-stage study data

BioPharma Drive: Drug Pricing

The company plans to file next year for an accelerated clearance of its "exon-skipping" treatment, which would compete with one of Sarepta's medicines.

Treatment 267
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Five minutes a day eccentric exercise can improve your life

Science Daily: Pharmacology News

As little as five minutes a day of eccentric exercise could offer significant health benefits to those living a stagnant lifestyle.

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Makary confirmed by Senate as FDA commissioner

BioPharma Drive: Drug Pricing

The Johns Hopkins surgeon will helm the agency as layoffs loom and important decisions on treatments for rare and infectious diseases await.

FDA 254
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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A safe nuclear battery that could last a lifetime

Science Daily: Pharmacology News

Lithium-ion batteries, used in consumer devices and electric vehicles, typically last hours or days between charges. However, with repeated use, they degrade and need to be charged more frequently. Now, researchers are considering radiocarbon as a source for safe, small and affordable nuclear batteries that could last decades or longer without charging.

Research 240
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Tuberculosis on the Rise Again in the United States

Drugs.com

WEDNESDAY, March 26, 2025 -- Preliminary data released this month by the U.S. Centers for Disease Control and Prevention indicate that more than 10,300 tuberculosis (TB) cases were reported last year, representing an 8 percent increase from 2023.

Disease 239
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Cuttlefish 'mesmerize' their prey with a moving skin pattern, study finds

Science Daily: Pharmacology News

While sneaking up on prey, cuttlefish employ a dynamic skin display to avoid detection in last moments of approach, researchers have found.

Research 229
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Gum May Be a Hidden Source of Microplastics

Drugs.com

WEDNESDAY, March 26, 2025 -- That stick of gum you’re chewing? It might be minty fresh, but it could also come with a little something extra: tiny bits of plastic. A new study finds that one piece of gum can release hundreds -- possibly.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Mini rolling robot takes virtual biopsies

Science Daily: Pharmacology News

A tiny magnetic robot which can take 3D scans from deep within the body, that could revolutionize early cancer detection, has been developed by researchers. The team say this is the first time it has been possible to generate high-resolution three-dimensional ultrasound images taken from a probe deep inside the gastrointestinal tract, or gut.

Research 226
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Epicrispr banks $68M to test epigenetic editing on rare muscle disease

BioPharma Drive: Drug Pricing

The startup is using CRISPR tools to stop errant expression of a gene linked to facioscapulohumeral muscular dystrophy, a disorder on the radars of several drugmakers.

Disease 195
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Entangled in self-discovery: Quantum computers analyze their own entanglement

Science Daily: Pharmacology News

Quantum computers are able to solve complex calculations that would take traditional computers thousands of years in just a few minutes. What if that analytical power is turned inwards towards the computer itself?

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Federal Government Pulls Back $11.4 Billion in COVID Health Funds

Drugs.com

WEDNESDAY, March 26, 2025 -- The federal government is clawing back $11.4 billion in COVID funding, a move that could affect local and state public health efforts across the country. The U.S. Department of Health and Human Services (HHS) said the.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Scientists uncover key mechanism in evolution: Whole-genome duplication drives long-term adaptation

Science Daily: Pharmacology News

Scientists uncovered how whole-genome duplication emerges and remains stable over thousands of generations of evolution in the lab.

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Bayer gains cancer drug from China’s Puhe; Axsome gets mixed ADHD data

BioPharma Drive: Drug Pricing

The German firm licensed a PRMT5 inhibitor that’s now in Phase 1 testing. Elsewhere, GSK is testing an intriguing hypothesis and Novo fine tuned its Wegovy cash-pay program.

Licensing 152
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Artificial intelligence uses less energy by mimicking the human brain

Science Daily: Pharmacology News

Electrical and computer engineers have developed a 'Super-Turing AI,' which operates more like the human brain. This new AI integrates certain processes instead of separating them and then migrating huge amounts of data like current systems do.

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FDA approves first-of-its-kind antibiotic from GSK

BioPharma Drive: Drug Pricing

The drug is a needed new option for treating uncomplicated UTIs, a common infection that’s becoming harder to treat as rates of microbial resistance rise.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Earliest days of Earth's formation

Science Daily: Pharmacology News

New research sheds light on the earliest days of the earth's formation and potentially calls into question some earlier assumptions in planetary science about the early years of rocky planets. Establishing a direct link between the Earth's interior dynamics occurring within the first 100 million years of its history and its present-day structure, the work is one of the first in the field to combine fluid mechanics with chemistry to better understand the Earth's early evolution.

Science 205
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Powerful MRI Scans Aid Epilepsy Surgery

Drugs.com

WEDNESDAY, March 26, 2025 -- The first sign of seizures for Amanda Bradbury were auras in her vision that cropped up around age 19.Then came frequent bouts of anxiety, struggling to maintain focus and follow conversations, forgetting things, and.

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New species revealed after 25 years of study on 'inside out' fossil -- and named after discoverer's mum

Science Daily: Pharmacology News

A new species of fossil is 444 million years-old with soft insides perfectly preserved. Research 'ultramarathon' saw palaeontologist puzzled by bizarre fossil for 25 years.

Research 195
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New Material Allows Amputees To Adjust Prosthetic Limb Fit Via Smartphone

Drugs.com

WEDNESDAY, March 26, 2025 -- Chafing, blisters and sores are common problems for people fitted with an artificial limb.The artificial limbs fixed, rigid shape cant adapt to changes in a persons body, ultimately causing it to rub against a perso.

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Researchers' breakthrough method reveals clouds amplify global warming far more than previously understood

Science Daily: Pharmacology News

Tropical marine low clouds play a crucial role in regulating Earth's climate. However, whether they mitigate or exacerbate global warming has long remained a mystery. Now, researchers have developed a groundbreaking method that significantly improves accuracy in climate predictions. This led to a major discovery -- that tropical cloud feedback may have amplified the greenhouse effect by a staggering 71% more than previously known to scientists.

Research 182
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New Moms Benefit From Regular Workouts

Drugs.com

WEDNESDAY, March 26, 2025 -- Childbirth is an overwhelming accomplishment, but new mothers would do best not to rest on their laurels following delivery, a new guideline says.New moms should clock at least two hours a week of moderate to vigorous.

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How did the large brain evolve?

Science Daily: Pharmacology News

Two specific genes that evolve exclusively in humans jointly influence the development of the cerebrum. Researchers have provided evidence that these genes contribute together to the evolutionary enlargement of the brain.

Research 179
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Support Systems: Building Your Multiple Sclerosis (MS) Care Team

Antidote

Living with multiple sclerosis (MS) can sometimes feel like youre navigating an unpredictable roadone with unexpected twists, turns, and detours. Theres so much information to absorb, decisions to make, and changes to navigate. At times, it might feel isolatingbut heres the truth: You are not alone in this.

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Cleaning microplastics

Science Daily: Pharmacology News

Proof-of-concept work uses unique, safe particles to remove microplastics in a single cycle.

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Bavtavirine

New Drug Approvals

Bavtavirine, CAS 1956373-71-9 KAJ2CK6ZYE 4-((4-Amino-8-(4-((1E)-2-cyanoethenyl)-2,6-dimethylphenyl)-2-quinazolinyl)amino)benzonitrile Benzonitrile, 4-((4-amino-8-(4-((1E)-2-cyanoethenyl)-2,6-dimethylphenyl)-2-quinazolinyl)amino)- C 26 H 20 N 6 416.48 Benzonitrile, 4-[[4-amino-8-[4-[(1 E )-2-cyanoethenyl]-2,6-dimethylphenyl]-2-quinazolinyl]amino]- Gilead Sciences, Inc.; Institute of Organic Chemistry and Biochemistry of the AS CR, v.v.i.