Covalent Modifiers
NOVEMBER 7, 2024
Thomas M. Geiger, Radosław P. Nowak Annual Reports in Medicinal Chemistry , 2024 [link] Proteolysis targeting chimeras (PROTACs) are hetero-bifunctional molecules that remove disease-causing proteins through the means of targeted protein degradation (TPD). Since their proof-of-concept over 20 years ago, PROTACs emerged as new modality in drug discovery and chemical biology.
Science Daily: Pharmacology News
NOVEMBER 7, 2024
It's common knowledge that our brains -- and, specifically, our brain cells -- store memories. But a team of scientists has discovered that cells from other parts of the body also perform a memory function, opening new pathways for understanding how memory works and creating the potential to enhance learning and to treat memory-related afflictions.
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Drugs.com
NOVEMBER 7, 2024
THURSDAY, Nov. 7, 2024 -- More than a year after its advisory panel unanimously declared the drug phenylephrine to be useless against nasal congestion, the U.S. Food and Drug Administration is proposing that it be removed from common.
Science Daily: Pharmacology News
NOVEMBER 7, 2024
Researchers have developed an innovative technique to search for black hole light echoes. Their novel method, which will make it easier for the mass and the spin of black holes to be measured, represents a major step forward, since it operates independently of many of the other ways in which scientists have probed these parameters in the past.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
BioPharma Drive: Drug Pricing
NOVEMBER 7, 2024
Elevidys sales have increased since the FDA made a controversial choice to expand the therapy's use. Now, Sarepta is abandoning a successor to its drug Exondys 51, citing an “evolving" treatment landscape.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Drugs.com
NOVEMBER 7, 2024
THURSDAY, Nov. 7, 2024 -- About 7% of dairy workers exposed to the avian flu that is spreading through U.S. herds have become infected themselves, federal experts estimate.That number highlights concerns that circulating strains of bird flu might.
Science Daily: Pharmacology News
NOVEMBER 7, 2024
Plastic pollution exacerbates the impacts of all planetary boundaries, including climate change, ocean acidification and biodiversity loss, a new paper shows. Ahead of the final negotiations of the international Plastics Treaty, researchers urge decision-makers to stop viewing plastics pollution as merely a waste management problem.
Drugs.com
NOVEMBER 7, 2024
THURSDAY, Nov. 7, 2024 (HeathDay News) -- The active chemical in “magic mushrooms” may help treat anorexia, a new study has found.Following psilocybin treatment, 4 of 10 study participants showed clinically significant reductions in their ano.
Science Daily: Pharmacology News
NOVEMBER 7, 2024
A recent study finds that color vision evolved in animals more than 100 million years before the emergence of colorful fruits and flowers. And there has been a dramatic explosion of color signals in the last 100 million years.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Drugs.com
NOVEMBER 7, 2024
THURSDAY, Nov. 7, 2024 -- Rates of anxiety and depression among U.S. adults, especially younger folks, continues to rise, the latest federal data shows.Nearly 1 in every 5 (18.2%) adults reported anxiety issues in 2022, up from 15.6% in 2019.
Science Daily: Pharmacology News
NOVEMBER 7, 2024
Genes contain instructions for making proteins, and a central dogma of biology is that this information flows from DNA to RNA to proteins. But only two percent of the human genome actually encodes proteins; the function of the remaining 98 percent remains largely unknown. One pressing problem in human genetics is to understand what these regions of the genome do -- if anything at all.
Drugs.com
NOVEMBER 7, 2024
THURSDAY, Nov. 7, 2024 -- Four cases of the more infectious variant of mpox have been reported in the U.K., making it the first cluster of infections that have surfaced outside of Africa.British authorities announced the first case in that country.
Common Sense for Drug Policy Blog
NOVEMBER 7, 2024
Responses of People Who Use Drugs to the Presence of Xylazine in the Unregulated Drug Supply "PWUD demonstrated a predominantly protective approach to xylazine emergence by modifying their drug consumption routes and reducing injection drug use, aiming to mitigate potential harms associated with xylazine adulteration. While often discussed in the context of xylazine here, this echoes a broader literature that reveals an elevated prevalence of smoking among people who previously injected opioids
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drugs.com
NOVEMBER 7, 2024
THURSDAY, Nov.7, 2024 -- Women who take vitamin D supplements during a pregnancy may be giving their kids the legacy of stronger bones, new British research suggests.Children whose moms took vitamin D supplements when pregnant had stronger, denser.
Zobio
NOVEMBER 7, 2024
ZoBio is excited to introduce a new exclusive capability for making complex protein samples for drug discovery: isotopic labeling during mammalian expression. This ability provides the missing link between. Het bericht Isotopic Labeling in Mammalian Expression: The Missing Link for NMR Studies of Hard-to-Express Proteins verscheen eerst op ZoBio - Drug Discovery Technology.
Drugs.com
NOVEMBER 7, 2024
THURSDAY, Nov. 7, 2024 -- It doesn't take much: Adding just five minutes of exercise to your daily routine lowers your blood pressure and might cut your odds for heart disease, new research shows.“The good news is that whatever your physical a.
Zobio
NOVEMBER 7, 2024
ZoBio is excited to introduce a new exclusive capability for making complex protein samples for drug discovery: isotopic labeling during mammalian expression. This ability provides the missing link between. Het bericht Isotopic Labeling in Mammalian Expression: The Missing Link for NMR Studies of Hard-to-Express Proteins verscheen eerst op ZoBio - Drug Discovery Technology.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Drugs.com
NOVEMBER 7, 2024
THURSDAY, Nov. 7, 2024 -- Memories are constantly adapting in the brain over time, dynamically updating as people encounter new information and fresh experiences.Researchers think they’ve figured out the brain mechanism that drives this memory i.
Alta Sciences
NOVEMBER 7, 2024
Sensitive ASO Quantitation for Decentralized Trials blussier Thu, 11/07/2024 - 17:55 HTML In this poster presentation, our scientific team demonstrates the promising future of blood microsampling in decentralized clinical trials to support the development of antisense therapeutic drugs. Find out how they achieved precision, accuracy, and linearity within acceptance criteria with our sensitive and selective bioanalytical method for determining ASOs.
Drugs.com
NOVEMBER 7, 2024
THURSDAY, Nov. 7, 2024 -- An experimental portable device might be able to detect lung cancer from a person’s exhaled breath, researchers report.The device contains “nanoflake” sensors that can detect small changes in the gases exhaled by a person w.
BioPharma Drive: Drug Pricing
NOVEMBER 7, 2024
Sales of Moderna’s COVID-19 shot exceeded expectations, but the company’s launch of its new RSV vaccine has started slowly.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Drugs.com
NOVEMBER 7, 2024
THURSDAY, Nov. 7, 2024 -- Seniors who are drowsy during the day and find it hard to muster enthusiasm for activities could be at higher risk of a brain condition that precedes dementia, a new study warns.These sleep-related problems are associated.
Science Daily: Pharmacology News
NOVEMBER 7, 2024
Readily available thermoelectric generators operating under modest temperature differences can power CO2 conversion, according to a proof-of-concept study by chemists. The findings open up the intriguing possibility that the temperature differentials encountered in an array of environments -- from a typical geothermal installation on Earth to the cold, desolate surface of Mars -- could power the conversion of CO2 into a range of useful fuels and chemicals.
Drugs.com
NOVEMBER 7, 2024
THURSDAY, Nov. 7, 2024 -- The head of the company that makes the diabetes and obesity drugs Ozempic and Wegovy has warned that compounded versions of the active ingredient in those medications have now been linked to at least 100 hospitalizations.
Science Daily: Pharmacology News
NOVEMBER 7, 2024
Researchers have used ancient DNA to challenge long-held interpretations of the people of Pompeii. Contrary to physical appearances, the DNA evidence revealed unexpected variations in gender and kinship, revising the story as written since 1748. The genetic data also underlined the cosmopolitan nature of the Roman Empire, showing that Pompeians were mainly descended from immigrants from the eastern Mediterranean.
Drugs.com
NOVEMBER 7, 2024
THURSDAY, Nov. 7, 2024 -- After "Friends" star Matthew Perry was found dead in his home jacuzzi just over a year ago, an autopsy later pinpointed the main cause of death as an acute ketamine overdose. The coroner's report determined that high blood.
NIOSH Science Blog: Drugs
NOVEMBER 7, 2024
Introduction No Shave November is a great opportunity to grow out your beard for a good cause. But if you rely on a tight-fitting respirator for work, that extra facial hair could pose a safety concern. Respirators protect workers from harmful particles, but their effectiveness depends on forming a tight seal against your skin. So, what does that mean for your growing beard during No Shave November?
Drugs.com
NOVEMBER 7, 2024
THURSDAY, Nov. 7, 2024 -- Abortion pills are safe and effective even very early in a pregnancy, a new study finds.Clinics and hospitals tend to defer medication abortions until a woman’s pregnancy is confirmed using ultrasound, researchers said.But.
Drug Patent Watch
NOVEMBER 7, 2024
The rising cost of prescription drugs has become a significant public health concern, with millions of Americans struggling to afford their medications. One crucial factor in mitigating this issue is the increased use of generic drugs. Generic drugs have been instrumental in reducing healthcare costs, and their impact cannot be overstated.
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