January, 2024

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CAR-T for lupus: the ‘tip of the iceberg’ for cell therapy in autoimmune disease

BioPharma Drive: Drug Pricing

Since a landmark paper in 2022, drugmakers have begun nearly a dozen trials of cell therapies for lupus, with more set to start. Here’s why their efforts are worth watching.

Therapies 141
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ADHD Drug Zenzedi Recalled Over Pill Mixup

Drugs.com

TUESDAY, Jan. 30, 2024 -- The maker of a drug used to treat ADHD and narcolepsy has recalled one lot of the medication after a pill mixup was discovered.The recall notice, issued by Azurity Pharmaceuticals Inc., states that one lot of Zenzedi.

Drugs 138
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Suppression of mast cell activation by GPR35: GPR35 is a primary target of disodium cromoglycate [Inflammation, Immunopharmacology, and Asthma]

ASPET

Mast cell stabilizers including disodium cromoglycate (DSCG) were found to have potential as the agonists of an orphan G protein-coupled receptor, GPR35, although it remains to be determined whether GPR35 is expressed in mast cells and involved in suppression of mast cell degranulation. Our purpose in this study is to verify the expression of GPR35 in mast cells, and to clarify how GPR35 modulates the degranulation.

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Curcumin affects apoptosis of colorectal cancer cells through ATF6?mediated endoplasmic reticulum stress

Chemical Biology and Drug Design

Curcumin activates ATF6-regulated endoplasmic reticulum (ER) stress, promotes ATF6 nuclear translocation, activates Chop/Bax/Bcl-2/Caspase-3 apoptosis pathway, and promotes apoptosis of CRC cells. Abstract Colorectal cancer (CRC) is the main cause of cancer-associated death. Herein, we treated SW620 and HT-29 CRC cells with different curcumin concentrations, followed by treatment with the half maximal inhibitory concentration (IC50) curcumin/endoplasmic reticulum stress (ERS) inhibitor 4-phenyl

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Claims that AI will “revolutionise pharma R&D” are (almost entirely) hype

DrugBaron

This month’s announcement that Alphabet’s Isomorphic Labs, led by the talented and charismatic Deepmind co-founder Demis Hassabis, had inked discovery collaboration deals with both Lilly and Novartis was just the latest indication that AI-enabled pharma R&D was ready for the big time. Billions of dollars have been invested in companies promising to “revolutionise pharma R&D” through the application of artificial intelligence – but it is now clear that global pharma companies, and not ju

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The science of ageing and restoring healthspan

Drug Target Review

What is “healthspan” and how does it relate to Life Bioscience’s mission? It is no mystery that as we age our health starts to deteriorate, and we become increasingly susceptible to diseases. If we take into consideration the timeframe of our lives, our “healthspan” is defined as the number of healthy years we live, which is different than our lifespan, the number of years of life.

Science 145

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Unprecedented ocean heating shows risks of a world 3°C warmer

Science Daily: Pharmacology News

New research examines the causes of the record-breaking ocean temperatures witnessed in 2023.

Research 142
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Novel Benzofuran Derivatives Induce Monoamine Release and Substitute for the Discriminative Stimulus Effects of 3,4-Methylenedioxymethamphetamine [Behavioral Pharmacology]

ASPET

3,4-Methylenedioxymethamphetamine (MDMA) has shown efficacy as a medication adjunct for treating post-traumatic stress disorder (PTSD). However, MDMA is also used in non-medical contexts that pose risk for cardiovascular and neurological complications. It is well established that MDMA exerts its effects by stimulating transporter-mediated release of the monoamines, 5-hydroxytryptamine (5-HT), norepinephrine, and dopamine.

Drugs 184
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10 clinical trials to watch in the first half of 2024

BioPharma Drive: Drug Pricing

A non-addictive pain pill faces its definitive test, while study results in ALS, a rare heart disease and lung cancer could have far-reaching implications.

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COVID Can Threaten Sickle Cell Patients, But Too Few Are Vaccinated

Drugs.com

FRIDAY, Jan. 12, 2024 -- Sickle cell disease is one of many chronic health conditions that dramatically increases the risk of hospitalization and death in people infected by COVID-19.Unfortunately, folks with sickle cell disease are much less.

Vaccine 141
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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AI in Drug Discovery - A Highly Opinionated Literature Review (Part III)

Practical Cheminformatics

Following up on Part I and Part II, the third post in this series is a collection of review articles published in 2023 that I found helpful.

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Sentiment & Themes Emerging From JPM 2024

LifeSciVC

By Aimee Raleigh, Principal at Atlas Venture, as part of the From The Trenches feature of LifeSciVC Just in time for new years’ reflections and resolutions, this year’s JPM felt like a refreshing burst of enthusiasm for a sector that has seen its challenges in 2022 and 2023 but also some green shoots. 2023 was a stellar year for M&A, comeback stories, burgeoning “hot” spaces, and for re-learning the basics of belt-tightening and careful capital allocation.

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Evolution might stop humans from solving climate change

Science Daily: Pharmacology News

Human culture has evolved to allow humans to extract resources and helped us expand to dominate the biosphere. But the same evolutionary processes may counteract efforts to solve new global environmental threats like climate change, according to a new study. Tackling the climate crisis will require worldwide regulatory, technical and economic systems supported by strong global cooperation.

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Battling antibiotic resistance in the lab and the clinic

Broad Institute

Battling antibiotic resistance in the lab and the clinic By Leah Eisenstadt January 30, 2024 Breadcrumb Home Battling antibiotic resistance in the lab and the clinic Physician-scientist Roby Bhattacharyya uses genomics and his experiences treating patients to study how “superbugs” evade drugs and find better ways to combat these dangerous pathogens.

Hospitals 137
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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A new startup from Feng Zhang and an ex-Illumina executive zeroes in on the epigenome

BioPharma Drive: Drug Pricing

Moonwalk Biosciences, the latest biotech cofounded by the gene editing scientist, joins other startups aiming to alter gene expression without changing DNA.

DNA 140
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A 'Universal' COVID Vaccine Could Save Billions If Another Pandemic Strikes

Drugs.com

FRIDAY, Jan. 12, 2024 -- A universal coronavirus vaccine could have saved millions of lives and billions of dollars if one had been available prior to the pandemic, a new study argues. Further, a universal vaccine -- one that targets parts of the.

Vaccine 137
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AI in Drug Discovery - A Highly Opinionated Literature Review (Part II)

Practical Cheminformatics

Picking up where we left off in Part I , this post covers several other ML in drug discovery topics that interested me in 2023. Some areas, like large language models, are new, and most of the work is at the proof-of-concept stage. Others, like active learning, are more mature, and several groups are starting to explore nuances of the methods. Here’s the structure of Part II. 4.

Drugs 141
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Addgene is Stopping Use of X (formerly Twitter)

addgene Blog

Addgene is announcing we have chosen to stop all activity on X, formerly Twitter. If you are interested in engaging with us on social media, you can find us on Bluesky: @addgene.bsky.social; or @addgene on Instagram, TikTok, Facebook, and LinkedIn. We are also exploring other social media platforms with active scientific communities and welcome suggestions in the comments.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Scientists identify how dietary restriction slows brain aging and increases lifespan

Science Daily: Pharmacology News

Restricting calories is known to improve health and increase lifespan, but much of how it does so remains a mystery, especially in regard to how it protects the brain. Scientists have now uncovered a role for a gene called OXR1 that is necessary for the lifespan extension seen with dietary restriction and is essential for healthy brain aging.

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Injectable agents could improve liquid biopsy for cancer detection and monitoring

Broad Institute

Injectable agents could improve liquid biopsy for cancer detection and monitoring By Corie Lok January 18, 2024 Breadcrumb Home Injectable agents could improve liquid biopsy for cancer detection and monitoring Researchers at Broad and MIT report the first injectable “priming agents” for liquid biopsy that increased circulating tumor DNA by more than 10-fold in mice.

DNA 133
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Non-opioid drug from Vertex cuts pain in major trial tests

BioPharma Drive: Drug Pricing

The company plans to soon ask the FDA for approval of the drug, which it has pitched as a safer alternative to addictive opioid painkillers.

Trials 135
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Study Links Use of Acetaminophen in Pregnancy With Child Behavioral Issues

Drugs.com

THURSDAY, Jan. 18, 2024 -- Expecting moms who often turn to acetaminophen for their aches and pains are more likely to wind up with kids who have behavioral issues, a new study warns.Children between the ages of 2 and 4 were more likely to have.

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Decoding stem cells for personalised regenerative medicine

Drug Target Review

In research published in Scientific Reports , 1 investigators focused on mesenchymal stem cells (MSCs), known for their potential in treating cell defects and regulating immune responses. Through a series of experiments, they successfully developed a personalised stem cell therapy using a data-driven, single-cell technique based on swift subcellular proteomic imaging.

RNA 128
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Clinical trial patient recruitment: 5 common misconceptions

Antidote

Though clinical trial patient recruitment is an integral part of the medical research process, it is often one of the most difficult aspects of conducting a study. There are various reasons for this challenge, and among them is the widespread existence of misconceptions about participating in research that many patients may see as a barrier to entry.

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Bottled water can contain hundreds of thousands of previously uncounted tiny plastic bits

Science Daily: Pharmacology News

In recent years, there has been rising concern that tiny particles known as microplastics are showing up basically everywhere on Earth, from polar ice to soil, drinking water and food. Formed when plastics break down into progressively smaller bits, these particles are being consumed by humans and other creatures, with unknown potential health and ecosystem effects.

Research 140
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Q&A: New approaches are needed to find better cancer drug targets

Broad Institute

Q&A: New approaches are needed to find better cancer drug targets By Allessandra DiCorato January 22, 2024 Breadcrumb Home Q&A: New approaches are needed to find better cancer drug targets Bill Sellers, head of Broad’s Cancer Program, talks about how to discover new classes of genetic dependencies that could move therapies closer to curing cancer patients.

Drugs 128
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Backed by billionaires, a new biomedical institute tests an unorthodox approach

BioPharma Drive: Drug Pricing

Arena BioWorks, which will be led by Harvard University scientist Stuart Schreiber, seeks to blend academic and venture capital drug research models.

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FDA Looking Into New Risks With Popular Weight-Loss Drugs

Drugs.com

THURSDAY, Jan. 4, 2024 -- The U.S. Food and Drug Administration is investigating reports of additional dangers linked to several wildly popular weight-loss drugs.In a quarterly report issued this week, the agency said it is investigating.

FDA 126
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Immuno-oncology innovations redefining cancer treatment in 2024

Drug Target Review

What innovative approaches and technologies are anticipated to reshape immuno-oncology treatments in 2024? Immuno-oncology, notably through checkpoint inhibitors, has significantly reshaped cancer treatment over the past decade. The current shift focuses on enhancing their efficacy by addressing the crucial need for robust T cell responses, an apparent bottleneck for broader impact.

Treatment 122
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Patient Perspective: Jamie Troil Goldfarb shares her clinical trial experience [video]

Antidote

For individuals living with a condition like melanoma, volunteering to participate in a clinical trial can be a rewarding experience. Not only will patients be able to gain access to potential new treatments, but they will also be directly contributing to research that can save lives — something that Jamie Troil Goldfarb has experienced firsthand. Jamie received a diagnosis of stage IV melanoma in 2011, only 11 weeks after giving birth to her child.

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Scientists design a two-legged robot powered by muscle tissue

Science Daily: Pharmacology News

Compared to robots, human bodies are flexible, capable of fine movements, and can convert energy efficiently into movement. Drawing inspiration from human gait, researchers from Japan crafted a two-legged biohybrid robot by combining muscle tissues and artificial materials. This method allows the robot to walk and pivot.

Research 132
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With retinal images and genetic data, researchers predict cardiovascular, metabolic, and other disease risks

Broad Institute

With retinal images and genetic data, researchers predict cardiovascular, metabolic, and other disease risks By Tom Ulrich January 25, 2024 Breadcrumb Home With retinal images and genetic data, researchers predict cardiovascular, metabolic, and other disease risks Images commonly taken as part of eye care may provide valuable information about patients' ocular and systemic health By Liana Wait January 25, 2024 Credit: Pete/Flickr Related news #WhyIScience Q&A: An aspiring physician-scientist inv

Disease 124
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Allogene to shift strategy in bid to reposition CAR-T

BioPharma Drive: Drug Pricing

The company plans to restructure and will start a new late-stage study testing whether its “off-the-shelf” therapy can boost cure rates when used early on.

Therapies 127