January, 2024

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World’s largest catalogue of ocean DNA could boost drug discovery

Drug Discovery World

The world’s most comprehensive database for understanding microbial distribution and function in the ocean has been released, opening up new opportunities for drug discovery. Scientists at the King Abdullah University of Science and Technology (KAUST) in Thuwal, Saudi Arabia used the KAUST Metagenomic Analysis Platform (KMAP) to analyse massive amounts of sequencing data to release Global Ocean Gene Catalog 1.0.

DNA 258
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CAR-T for lupus: the ‘tip of the iceberg’ for cell therapy in autoimmune disease

BioPharma Drive: Drug Pricing

Since a landmark paper in 2022, drugmakers have begun nearly a dozen trials of cell therapies for lupus, with more set to start. Here’s why their efforts are worth watching.

Therapies 141
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ADHD Drug Zenzedi Recalled Over Pill Mixup

Drugs.com

TUESDAY, Jan. 30, 2024 -- The maker of a drug used to treat ADHD and narcolepsy has recalled one lot of the medication after a pill mixup was discovered.The recall notice, issued by Azurity Pharmaceuticals Inc., states that one lot of Zenzedi.

Drugs 138
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The Political Theater Of Importing Prescription Drugs From Canada

Forbes: Drug Truths

The FDA had been previously reluctant to approve such a plan for safety concerns.

FDA 249
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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The science of ageing and restoring healthspan

Drug Target Review

What is “healthspan” and how does it relate to Life Bioscience’s mission? It is no mystery that as we age our health starts to deteriorate, and we become increasingly susceptible to diseases. If we take into consideration the timeframe of our lives, our “healthspan” is defined as the number of healthy years we live, which is different than our lifespan, the number of years of life.

Science 145
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Sentiment & Themes Emerging From JPM 2024

LifeSciVC

By Aimee Raleigh, Principal at Atlas Venture, as part of the From The Trenches feature of LifeSciVC Just in time for new years’ reflections and resolutions, this year’s JPM felt like a refreshing burst of enthusiasm for a sector that has seen its challenges in 2022 and 2023 but also some green shoots. 2023 was a stellar year for M&A, comeback stories, burgeoning “hot” spaces, and for re-learning the basics of belt-tightening and careful capital allocation.

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Evolution might stop humans from solving climate change

Science Daily: Pharmacology News

Human culture has evolved to allow humans to extract resources and helped us expand to dominate the biosphere. But the same evolutionary processes may counteract efforts to solve new global environmental threats like climate change, according to a new study. Tackling the climate crisis will require worldwide regulatory, technical and economic systems supported by strong global cooperation.

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COVID Can Threaten Sickle Cell Patients, But Too Few Are Vaccinated

Drugs.com

FRIDAY, Jan. 12, 2024 -- Sickle cell disease is one of many chronic health conditions that dramatically increases the risk of hospitalization and death in people infected by COVID-19.Unfortunately, folks with sickle cell disease are much less.

Vaccine 141
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Deliberate Dysentery

Codon

Introduction The intentional infection of human beings with pathogens under study has been going on for centuries. In 1796, an English physician named Edward Jenner inoculated an 8-year-old boy against smallpox with cowpox lesions he retrieved from the hands of a dairymaid. Today, refined versions of these human challenge studies have become standard practice in testing vaccines for vector-borne diseases (e.g., yellow fever, malaria, and dengue), evaluating new drugs or treatments, and studying

Vaccine 132
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10 clinical trials to watch in the first half of 2024

BioPharma Drive: Drug Pricing

A non-addictive pain pill faces its definitive test, while study results in ALS, a rare heart disease and lung cancer could have far-reaching implications.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Addgene is Stopping Use of X (formerly Twitter)

addgene Blog

Addgene is announcing we have chosen to stop all activity on X, formerly Twitter. If you are interested in engaging with us on social media, you can find us on Bluesky: @addgene.bsky.social; or @addgene on Instagram, TikTok, Facebook, and LinkedIn. We are also exploring other social media platforms with active scientific communities and welcome suggestions in the comments.

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CAR-T therapy could “alter the treatment paradigm” of multiple sclerosis

Drug Discovery World

Kyverna Therapeutics has revealed plans to progress to Phase II trials of KYV-101 for multiple sclerosis (MS) following a green light from the US Food and Drug Administration (FDA). KYV-101 is an autologous, fully human CD19 chimeric antigen receptor (CAR) T-cell product candidate for use in B cell-driven autoimmune diseases. “This approval is a critically necessary step that paves the way to enrol patients with treatment-refractory progressive MS for whom there are no currently available

Therapies 312
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Scientists identify how dietary restriction slows brain aging and increases lifespan

Science Daily: Pharmacology News

Restricting calories is known to improve health and increase lifespan, but much of how it does so remains a mystery, especially in regard to how it protects the brain. Scientists have now uncovered a role for a gene called OXR1 that is necessary for the lifespan extension seen with dietary restriction and is essential for healthy brain aging.

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A 'Universal' COVID Vaccine Could Save Billions If Another Pandemic Strikes

Drugs.com

FRIDAY, Jan. 12, 2024 -- A universal coronavirus vaccine could have saved millions of lives and billions of dollars if one had been available prior to the pandemic, a new study argues. Further, a universal vaccine -- one that targets parts of the.

Vaccine 137
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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With retinal images and genetic data, researchers predict cardiovascular, metabolic, and other disease risks

Broad Institute

With retinal images and genetic data, researchers predict cardiovascular, metabolic, and other disease risks By Tom Ulrich January 25, 2024 Breadcrumb Home With retinal images and genetic data, researchers predict cardiovascular, metabolic, and other disease risks Images commonly taken as part of eye care may provide valuable information about patients' ocular and systemic health By Liana Wait January 25, 2024 Credit: Pete/Flickr Related news #WhyIScience Q&A: An aspiring physician-scientist inv

Disease 124
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A new startup from Feng Zhang and an ex-Illumina executive zeroes in on the epigenome

BioPharma Drive: Drug Pricing

Moonwalk Biosciences, the latest biotech cofounded by the gene editing scientist, joins other startups aiming to alter gene expression without changing DNA.

DNA 140
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AI in Drug Discovery - A Highly Opinionated Literature Review (Part III)

Practical Cheminformatics

Following up on Part I and Part II, the third post in this series is a collection of review articles published in 2023 that I found helpful.

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Research reveals an immune cell that can kill all cancers

Drug Discovery World

Researchers in the US have discovered that a type of immune cell in the human body known to be important for allergy and other immune responses can also attack cancer. Furthermore, these cells, called human type 2 innate lymphoid cells (ILC2s), can be expanded outside of the body and applied in larger numbers to overpower a tumour’s defenses and eliminate malignant cells in mouse models with cancer.

Research 289
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Bottled water can contain hundreds of thousands of previously uncounted tiny plastic bits

Science Daily: Pharmacology News

In recent years, there has been rising concern that tiny particles known as microplastics are showing up basically everywhere on Earth, from polar ice to soil, drinking water and food. Formed when plastics break down into progressively smaller bits, these particles are being consumed by humans and other creatures, with unknown potential health and ecosystem effects.

Research 134
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Study Links Use of Acetaminophen in Pregnancy With Child Behavioral Issues

Drugs.com

THURSDAY, Jan. 18, 2024 -- Expecting moms who often turn to acetaminophen for their aches and pains are more likely to wind up with kids who have behavioral issues, a new study warns.Children between the ages of 2 and 4 were more likely to have.

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Clinical trial patient recruitment: 5 common misconceptions

Antidote

Though clinical trial patient recruitment is an integral part of the medical research process, it is often one of the most difficult aspects of conducting a study. There are various reasons for this challenge, and among them is the widespread existence of misconceptions about participating in research that many patients may see as a barrier to entry.

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Kyverna sets plans for IPO in test of biotech market

BioPharma Drive: Drug Pricing

The offering is the fifth outlined by a biotech startup this month, suggesting companies are becoming more willing to gauge investors’ appetite for new stock offerings.

Marketing 123
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Immuno-oncology innovations redefining cancer treatment in 2024

Drug Target Review

What innovative approaches and technologies are anticipated to reshape immuno-oncology treatments in 2024? Immuno-oncology, notably through checkpoint inhibitors, has significantly reshaped cancer treatment over the past decade. The current shift focuses on enhancing their efficacy by addressing the crucial need for robust T cell responses, an apparent bottleneck for broader impact.

Treatment 119
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Biotech funding recovery predicted for 2024

Drug Discovery World

The biotech market is heading to recovery in 2024, following a marked downturn in investment in 2022 and 2023, according to healthcare industry professionals. A GlobalData survey ‘The State of the Biopharmaceutical Industry 2024’ found that more than 40% of the healthcare industry professionals surveyed globally expressed an optimistic or very optimistic sentiment on biotech funding starting to bounce back over the next 12 months.

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Scientists design a two-legged robot powered by muscle tissue

Science Daily: Pharmacology News

Compared to robots, human bodies are flexible, capable of fine movements, and can convert energy efficiently into movement. Drawing inspiration from human gait, researchers from Japan crafted a two-legged biohybrid robot by combining muscle tissues and artificial materials. This method allows the robot to walk and pivot.

Research 124
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FDA Looking Into New Risks With Popular Weight-Loss Drugs

Drugs.com

THURSDAY, Jan. 4, 2024 -- The U.S. Food and Drug Administration is investigating reports of additional dangers linked to several wildly popular weight-loss drugs.In a quarterly report issued this week, the agency said it is investigating.

FDA 126
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Patient Perspective: Jamie Troil Goldfarb shares her clinical trial experience [video]

Antidote

For individuals living with a condition like melanoma, volunteering to participate in a clinical trial can be a rewarding experience. Not only will patients be able to gain access to potential new treatments, but they will also be directly contributing to research that can save lives — something that Jamie Troil Goldfarb has experienced firsthand. Jamie received a diagnosis of stage IV melanoma in 2011, only 11 weeks after giving birth to her child.

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AstraZeneca, Daiichi aim for first pan-tumor ADC approval

BioPharma Drive: Drug Pricing

The FDA is reviewing the companies’ application for a “tumor agnostic” indication for their drug Enhertu, which would break new ground for antibody-drug conjugates.

FDA 121
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Deep Dive into IBM Sterling Certified Containers and Cloud Solutions

Perficient: Drug Development

Many retailers are embarking on a digital transformation to modernize and scale their order management system (OMS) solution. Built on a modern architecture, the solution wraps Docker containers around order management business services. This architecture streamlines application management and the release of new functionality. The container technology also supports varying levels of technical acumen, business continuity, security, and compliance.

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Merck continues to boost oncology pipeline through acquisitions

Drug Discovery World

Merck (MSD), through a subsidiary, has agreed to acquire immunotherapy company Harpoon Therapeutics for $680 million. The acquisition includes HPN328, an investigational delta-like ligand 3 (DLL3) targeting T-cell engager being evaluated in certain patients with small cell lung cancer and neuroendocrine tumours. The announcement follows the news that Merck agreed a deal with Inspirna for colorectal cancer drug ompenaclid (RGX-202).

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Trees struggle to 'breathe' as climate warms

Science Daily: Pharmacology News

Trees are struggling to sequester heat-trapping carbon dioxide (CO2) in warmer, drier climates, meaning that they may no longer serve as a solution for offsetting humanity's carbon footprint as the planet continues to warm, according to a new study.

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More Americans Will Only Have to Pay $35 a Month for Insulin in 2024

Drugs.com

TUESDAY, Jan. 2, 2024 -- Managing diabetes will be a less expensive proposition for more Americans in 2024.Sanofi has officially joined Novo Nordisk and Eli Lilly in lowering the cost of insulin to $35 a month for many patients. The three.

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What to know after a colon cancer diagnosis

Antidote

Colorectal cancer (often shortened simply to colon cancer) is the fourth-most commonly diagnosed cancer in the United States, and it is estimated that around 150,000 Americans are diagnosed each year. While the average age of diagnosis is 66, young adults are getting diagnosed in higher numbers every year, and researchers are still unsure as to why.

Research 122
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Allogene to shift strategy in bid to reposition CAR-T

BioPharma Drive: Drug Pricing

The company plans to restructure and will start a new late-stage study testing whether its “off-the-shelf” therapy can boost cure rates when used early on.

Therapies 126