Drug Discovery World

JANUARY 23, 2024

The world’s most comprehensive database for understanding microbial distribution and function in the ocean has been released, opening up new opportunities for drug discovery. Scientists at the King Abdullah University of Science and Technology (KAUST) in Thuwal, Saudi Arabia used the KAUST Metagenomic Analysis Platform (KMAP) to analyse massive amounts of sequencing data to release Global Ocean Gene Catalog 1.0.

DNA 258

DNA Drugs Science 258

BioPharma Drive: Drug Pricing

JANUARY 30, 2024

Since a landmark paper in 2022, drugmakers have begun nearly a dozen trials of cell therapies for lupus, with more set to start. Here’s why their efforts are worth watching.

Therapies 141

Therapies Disease Trials 141

Drugs.com

JANUARY 30, 2024

TUESDAY, Jan. 30, 2024 -- The maker of a drug used to treat ADHD and narcolepsy has recalled one lot of the medication after a pill mixup was discovered.The recall notice, issued by Azurity Pharmaceuticals Inc., states that one lot of Zenzedi.

Drugs 138

Drugs Pharmaceuticals 138

Forbes: Drug Truths

JANUARY 11, 2024

The FDA had been previously reluctant to approve such a plan for safety concerns.

FDA 249

FDA Drugs 249

Advertisement

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Target Review

JANUARY 8, 2024

What is “healthspan” and how does it relate to Life Bioscience’s mission? It is no mystery that as we age our health starts to deteriorate, and we become increasingly susceptible to diseases. If we take into consideration the timeframe of our lives, our “healthspan” is defined as the number of healthy years we live, which is different than our lifespan, the number of years of life.

Science 145

Science Disease FDA Approval Pharmaceutical Companies 145

Science Daily: Pharmacology News

JANUARY 2, 2024

Human culture has evolved to allow humans to extract resources and helped us expand to dominate the biosphere. But the same evolutionary processes may counteract efforts to solve new global environmental threats like climate change, according to a new study. Tackling the climate crisis will require worldwide regulatory, technical and economic systems supported by strong global cooperation.

141

141

LifeSciVC

JANUARY 16, 2024

By Aimee Raleigh, Principal at Atlas Venture, as part of the From The Trenches feature of LifeSciVC Just in time for new years’ reflections and resolutions, this year’s JPM felt like a refreshing burst of enthusiasm for a sector that has seen its challenges in 2022 and 2023 but also some green shoots. 2023 was a stellar year for M&A, comeback stories, burgeoning “hot” spaces, and for re-learning the basics of belt-tightening and careful capital allocation.

Small Molecule 140

Small Molecule Trials Therapies Disease 140

Drugs.com

JANUARY 12, 2024

FRIDAY, Jan. 12, 2024 -- Sickle cell disease is one of many chronic health conditions that dramatically increases the risk of hospitalization and death in people infected by COVID-19.Unfortunately, folks with sickle cell disease are much less.

Vaccine 141

Vaccine Hospitals Disease 141

BioPharma Drive: Drug Pricing

JANUARY 2, 2024

A non-addictive pain pill faces its definitive test, while study results in ALS, a rare heart disease and lung cancer could have far-reaching implications.

Clinical Trials 143

Clinical Trials Trials Disease 143

addgene Blog

JANUARY 11, 2024

Addgene is announcing we have chosen to stop all activity on X, formerly Twitter. If you are interested in engaging with us on social media, you can find us on Bluesky: @addgene.bsky.social; or @addgene on Instagram, TikTok, Facebook, and LinkedIn. We are also exploring other social media platforms with active scientific communities and welcome suggestions in the comments.

129

129

Advertisement

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Science Daily: Pharmacology News

JANUARY 11, 2024

Restricting calories is known to improve health and increase lifespan, but much of how it does so remains a mystery, especially in regard to how it protects the brain. Scientists have now uncovered a role for a gene called OXR1 that is necessary for the lifespan extension seen with dietary restriction and is essential for healthy brain aging.

136

136

Drug Discovery World

JANUARY 5, 2024

Kyverna Therapeutics has revealed plans to progress to Phase II trials of KYV-101 for multiple sclerosis (MS) following a green light from the US Food and Drug Administration (FDA). KYV-101 is an autologous, fully human CD19 chimeric antigen receptor (CAR) T-cell product candidate for use in B cell-driven autoimmune diseases. “This approval is a critically necessary step that paves the way to enrol patients with treatment-refractory progressive MS for whom there are no currently available

Therapies 312

Therapies Treatment Protein Expression Trials 312

Codon

JANUARY 21, 2024

Introduction The intentional infection of human beings with pathogens under study has been going on for centuries. In 1796, an English physician named Edward Jenner inoculated an 8-year-old boy against smallpox with cowpox lesions he retrieved from the hands of a dairymaid. Today, refined versions of these human challenge studies have become standard practice in testing vaccines for vector-borne diseases (e.g., yellow fever, malaria, and dengue), evaluating new drugs or treatments, and studying

Vaccine 128

Vaccine Trials Disease Virus 128

Drugs.com

JANUARY 12, 2024

FRIDAY, Jan. 12, 2024 -- A universal coronavirus vaccine could have saved millions of lives and billions of dollars if one had been available prior to the pandemic, a new study argues. Further, a universal vaccine -- one that targets parts of the.

Vaccine 137

Vaccine 137

Advertisement

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

BioPharma Drive: Drug Pricing

JANUARY 4, 2024

Moonwalk Biosciences, the latest biotech cofounded by the gene editing scientist, joins other startups aiming to alter gene expression without changing DNA.

DNA 140

DNA 140

Practical Cheminformatics

JANUARY 16, 2024

Following up on Part I and Part II, the third post in this series is a collection of review articles published in 2023 that I found helpful.

Targeted Protein Degradation 141

Targeted Protein Degradation Small Molecule Computational Chemistry Bioinformatics 141

Science Daily: Pharmacology News

JANUARY 8, 2024

In recent years, there has been rising concern that tiny particles known as microplastics are showing up basically everywhere on Earth, from polar ice to soil, drinking water and food. Formed when plastics break down into progressively smaller bits, these particles are being consumed by humans and other creatures, with unknown potential health and ecosystem effects.

Research 135

Research 135

Drug Discovery World

JANUARY 12, 2024

Researchers in the US have discovered that a type of immune cell in the human body known to be important for allergy and other immune responses can also attack cancer. Furthermore, these cells, called human type 2 innate lymphoid cells (ILC2s), can be expanded outside of the body and applied in larger numbers to overpower a tumour’s defenses and eliminate malignant cells in mouse models with cancer.

Research 289

Research Immune Response Virus Therapies 289

Antidote

JANUARY 5, 2024

Though clinical trial patient recruitment is an integral part of the medical research process, it is often one of the most difficult aspects of conducting a study. There are various reasons for this challenge, and among them is the widespread existence of misconceptions about participating in research that many patients may see as a barrier to entry.

Clinical Trials 124

Clinical Trials Trials Research 124

Drugs.com

JANUARY 18, 2024

THURSDAY, Jan. 18, 2024 -- Expecting moms who often turn to acetaminophen for their aches and pains are more likely to wind up with kids who have behavioral issues, a new study warns.Children between the ages of 2 and 4 were more likely to have.

128

128

Broad Institute

JANUARY 25, 2024

With retinal images and genetic data, researchers predict cardiovascular, metabolic, and other disease risks By Tom Ulrich January 25, 2024 Breadcrumb Home With retinal images and genetic data, researchers predict cardiovascular, metabolic, and other disease risks Images commonly taken as part of eye care may provide valuable information about patients' ocular and systemic health By Liana Wait January 25, 2024 Credit: Pete/Flickr Related news #WhyIScience Q&A: An aspiring physician-scientist inv

Disease 120

Disease Research Medical Schools Science 120

BioPharma Drive: Drug Pricing

JANUARY 17, 2024

The offering is the fifth outlined by a biotech startup this month, suggesting companies are becoming more willing to gauge investors’ appetite for new stock offerings.

Marketing 123

Marketing 123

Science Daily: Pharmacology News

JANUARY 31, 2024

Trees are struggling to sequester heat-trapping carbon dioxide (CO2) in warmer, drier climates, meaning that they may no longer serve as a solution for offsetting humanity's carbon footprint as the planet continues to warm, according to a new study.

133

133

Drug Discovery World

JANUARY 10, 2024

The biotech market is heading to recovery in 2024, following a marked downturn in investment in 2022 and 2023, according to healthcare industry professionals. A GlobalData survey ‘The State of the Biopharmaceutical Industry 2024’ found that more than 40% of the healthcare industry professionals surveyed globally expressed an optimistic or very optimistic sentiment on biotech funding starting to bounce back over the next 12 months.

Pharmaceutical Companies 288

Pharmaceutical Companies Marketing International Pharmaceuticals 288

Antidote

JANUARY 29, 2024

For individuals living with a condition like melanoma, volunteering to participate in a clinical trial can be a rewarding experience. Not only will patients be able to gain access to potential new treatments, but they will also be directly contributing to research that can save lives — something that Jamie Troil Goldfarb has experienced firsthand. Jamie received a diagnosis of stage IV melanoma in 2011, only 11 weeks after giving birth to her child.

Clinical Trials 122

Clinical Trials Trials Doctors Treatment 122

Drugs.com

JANUARY 4, 2024

THURSDAY, Jan. 4, 2024 -- The U.S. Food and Drug Administration is investigating reports of additional dangers linked to several wildly popular weight-loss drugs.In a quarterly report issued this week, the agency said it is investigating.

FDA 126

FDA Drugs 126

Drug Target Review

JANUARY 23, 2024

What innovative approaches and technologies are anticipated to reshape immuno-oncology treatments in 2024? Immuno-oncology, notably through checkpoint inhibitors, has significantly reshaped cancer treatment over the past decade. The current shift focuses on enhancing their efficacy by addressing the crucial need for robust T cell responses, an apparent bottleneck for broader impact.

Treatment 122

Treatment Immune Response Vaccine Therapies 122

BioPharma Drive: Drug Pricing

JANUARY 29, 2024

The FDA is reviewing the companies’ application for a “tumor agnostic” indication for their drug Enhertu, which would break new ground for antibody-drug conjugates.

FDA 121

FDA Drugs 121

Science Daily: Pharmacology News

JANUARY 18, 2024

Researchers have designed a self-powering, battery-free, energy-harvesting sensor. Using the framework they developed, they produced a temperature sensor that can harvest and store the energy from the magnetic field that exists in the open air around a wire.

Research 131

Research 131

Drug Discovery World

JANUARY 15, 2024

Merck (MSD), through a subsidiary, has agreed to acquire immunotherapy company Harpoon Therapeutics for $680 million. The acquisition includes HPN328, an investigational delta-like ligand 3 (DLL3) targeting T-cell engager being evaluated in certain patients with small cell lung cancer and neuroendocrine tumours. The announcement follows the news that Merck agreed a deal with Inspirna for colorectal cancer drug ompenaclid (RGX-202).

Clinical Development 263

Clinical Development Research Laboratories Clinical Trials Laboratories 263

Antidote

JANUARY 26, 2024

Colorectal cancer (often shortened simply to colon cancer) is the fourth-most commonly diagnosed cancer in the United States, and it is estimated that around 150,000 Americans are diagnosed each year. While the average age of diagnosis is 66, young adults are getting diagnosed in higher numbers every year, and researchers are still unsure as to why.

Research 122

Research 122

Drugs.com

JANUARY 2, 2024

TUESDAY, Jan. 2, 2024 -- Managing diabetes will be a less expensive proposition for more Americans in 2024.Sanofi has officially joined Novo Nordisk and Eli Lilly in lowering the cost of insulin to $35 a month for many patients. The three.

124

124

Perficient: Drug Development

JANUARY 19, 2024

Many retailers are embarking on a digital transformation to modernize and scale their order management system (OMS) solution. Built on a modern architecture, the solution wraps Docker containers around order management business services. This architecture streamlines application management and the release of new functionality. The container technology also supports varying levels of technical acumen, business continuity, security, and compliance.

Compliance 118

Compliance Marketing Licensing Licensing 118

BioPharma Drive: Drug Pricing

JANUARY 4, 2024

The company plans to restructure and will start a new late-stage study testing whether its “off-the-shelf” therapy can boost cure rates when used early on.

Therapies 126

Therapies 126