Sat.Apr 06, 2024 - Fri.Apr 12, 2024

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Vodcast: Dr Adriano Flora, The Jackson Laboratory

Drug Discovery World

The latest sponsored DDW Sitting Down With vodcast features Dr Adriano Flora, Director of Business Development at The Jackson Laboratory (JAX). He discusses alternatives to non-human primates, the key benefits of this, and what impact will they have on the future of drug development. Moreover, he answers questions on the key breakthroughs in recent years in this field and how have these impacted future success, as well as challenges in the clinic that must be overcome to ensure this success is a

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Will Biopharma Companies Shun Vaccine R&D In A New Pandemic?

Forbes: Drug Truths

Only biopharma could have combated Covid-19; no other industry has the capacity to do so. When the world was in crisis, this industry responded. If need be, it will again, despite the financial consequences.

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Trending Sources

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Parkinson's Disease: New theory on the disease's origins and spread

Science Daily: Pharmacology News

New hypothesis paper builds on a growing scientific consensus that Parkinson's disease route to the brain starts in either the nose or the gut and proposes that environmental toxicants are the likely source.

Disease 143
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Psychiatry drugs finally have pharma’s attention. Can they keep it?

BioPharma Drive: Drug Pricing

Recent biotech company acquisitions have put emerging schizophrenia treatments in focus. But many development hurdles still stand in the way of new medicines for the brain.

Treatment 135
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Meet the Researcher: Stefano Gullà, Kling Biotherapeutics

Drug Discovery World

DDW’s Megan Thomas speaks to Stefano Gullà, Chief Scientific Officer at Kling Biotherapeutics. MT: Where do you work, and can you tell us what you’re working on at the moment? SG: I am the Chief Scientific Officer at Kling Biotherapeutics. Together with my colleagues, I am tackling what is one of the most pressing problems in biotech, the discovery of targets to serve as the basis for new therapies for cancer and infectious diseases.

Research 147
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Using Internal Traffic Control Plans to Prevent Construction Worker Injuries and Fatalities in Work Zones

NIOSH Science Blog: Drugs

Struck-by injuries are the leading cause of nonfatal injuries and second most common cause of fatalities among construction workers. From 2011 to 2022, there were 1,462 fatal occupational injuries that occurred at road construction sites.[1] Of these, 68% (n=1,000) were among workers in the construction industry (See figure) followed by workers in transportation and warehousing (11%; n=168) and professional and business services (9%; n=132) industries.

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New postpartum depression drugs are here. Diagnosis, treatment hurdles still stand in the way.

BioPharma Drive: Drug Pricing

The first medicine approved for PPD, Sage’s Zulresso, never gained traction. The company is in the midst of launching its second, but long-standing challenges could slow uptake.

Treatment 124
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Where is the opportunity in the therapeutic antibody market?

Drug Discovery World

In this free webinar, you will hear from Dr Jill O’Donnell-Tormey, CEO and Director of Scientific Affairs at Cancer Research Institute; Dr Roger Levy, Senior Global Medical Director, GSK Specialty Medicine; Dr Sheila Keating, VP of Immunology at Gigagen; as well as event sponsors Dr Milind Nigam, Leader – Scientific Solutions Consulting at Benchling, and Dr Paola Genevini, Technical Sales Specialist at Bio-Rad.

Marketing 147
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Chlamydia Vaccine Shows Promise in Early Trial

Drugs.com

FRIDAY, April 12, 2024 -- A chlamydia vaccine has triggered immune responses in an early trial, raising hopes that one day it might help curb the spread of the sexually transmitted infection (STI).There is currently no vaccine for chlamydia, which.

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Star Trek's Holodeck recreated using ChatGPT and video game assets

Science Daily: Pharmacology News

Star Trek's Holodeck is no longer just science fiction. Using AI, engineers have created a tool that can generate 3D environments, prompted by everyday language.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Novartis pauses some trials of cancer drug Kisqali to fix manufacturing

BioPharma Drive: Drug Pricing

The company said the pause is necessary to meet regulatory limits on nitrosamine, but added it will not affect commercial supply nor regulatory review of the drug in early breast cancer.

Trials 112
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This week in drug discovery (8-12 April) 

Drug Discovery World

News round-up for 8-12 April by DDW Digital Content Editor Diana Spencer. The cancer research news has been coming thick and fast from the American Association of Cancer Research (AACR) Annual Meeting in San Diego this week, so our Friday round-up focuses on drug discovery in oncology. The top stories: Genetically engineered dendritic cells enhance lung cancer therapy A study by researchers at the UCLA Health Jonsson Comprehensive Cancer Center in the US suggests that injecting engineered dendri

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Many Cancer Drugs Still Unproven 5 Years After Accelerated Approval

Drugs.com

MONDAY, April 8, 2024 -- New research questions the effectiveness of the U.S. Food and Drug Administration's accelerated drug approval program after finding that many cancer drugs remain unproven five years later.The study, published Sunday in the.

Drugs 116
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Revolutionary molecular device unleashes potential for targeted drug delivery and self-healing materials

Science Daily: Pharmacology News

In a new breakthrough that could revolutionise medical and material engineering, scientists have developed a first-of-its-kind molecular device that controls the release of multiple small molecules using force.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Vertex to buy kidney disease drugmaker Alpine for $4.9B

BioPharma Drive: Drug Pricing

The deal, which company CEO Reshma Kewalramani described as “just the right fit,” is the largest acquistion in Vertex’s 35-year history.

Disease 120
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First tumour agnostic HER2 directed ADC gets US approval

Drug Discovery World

Daiichi Sankyo and AstraZeneca’s Enhertu (fam-trastuzumab deruxtecan-nxki) has been approved in the US for the treatment of adult patients with unresectable or metastatic HER2 positive (immunohistochemistry [IHC] 3+) solid tumours. Enhertu has been granted accelerated approval to treat patients who have received prior systemic treatment and have no satisfactory alternative treatment options.

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Spike in Measles Cases Could Threaten Elimination Status in U.S.: CDC

Drugs.com

FRIDAY, April 12, 2024 -- More than 100 measles cases have already been reported in the United States this year, a significant increase over previous years that threatens the country's attempts to eliminate the illness, federal health officials.

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Inherited predisposition for higher muscle strength may protect against common morbidities

Science Daily: Pharmacology News

A study showed that a genetic predisposition for higher muscle strength predicts a longer lifespan and a lower risk for developing common diseases. This is a highly comprehensive international study on hereditary muscle strength and its relationship to morbidity. The genome and health data of more than 340,000 Finns was used in the research.

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Three Principles for Writing Effective Analytics Documentation

Perficient: Drug Development

Documentation is a crucial part of your analytics implementation. From your Solution Design Reference document to your internal wiki for all resources, making sure that you can write and edit your documentation is key to ensuring a cohesive and thorough understanding of your implementation. With effective documentation, you can: Prevent knowledge gaps among team members and assist in onboarding efforts.

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FDA green light for trial of allogeneic regulatory T cell therapy

Drug Discovery World

The US Food and Drug Administration (FDA) has accepted an Investigational New Drug (IND) application for Tr1X’s TRX103 for the prevention of Graft versus Host Disease (GvHD) in patients undergoing HLA-mismatched haematopoietic stem cell transplantation (HSCT). The company plans to initiate a Phase I study of the investigational allogeneic off-the-shelf Tr1 Treg therapy for this indication in the second quarter of 2024.

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Household Radon Can Lead to Lung Cancer -- Has Your Home Been Tested?

Drugs.com

THURSDAY, April 11, 2024 -- Kentucky resident Chasity Harney embraced a thoroughly healthy lifestyle -- eating right, exercising and never touching tobacco.So, her 2018 diagnosis of advanced lung cancer, which came at the age of 40, was a complete.

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Bonobos are more aggressive than previously thought

Science Daily: Pharmacology News

Chimpanzees and bonobos are often thought to reflect two different sides of human nature -- the conflict-ready chimpanzee versus the peaceful bonobo -- but a new study shows that, within their own communities, male bonobos are more frequently aggressive than male chimpanzees. For both species, more aggressive males had more mating opportunities.

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Innovative Financing Models for Repurposing Generic Drugs

Drug Patent Watch

A paper presented at the 2nd International Conference on Systems Medicine, AI, and Drug Repurposing proposes a novel approach to overcoming the financial barriers associated with repurposing generic drugs through… Source

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Study casts doubt on benefit of ‘accelerated approval’ cancer drugs

Drug Discovery World

Forty-one percent of cancer drugs granted accelerated approval from 2013 to 2017 did not demonstrate clinical benefit in confirmatory trials, according to a study in the Journal of the American Medical Association ( JAMA). The paper ‘Clinical Benefit and Regulatory Outcomes of Cancer Drugs Receiving Accelerated Approval’ reviewed 46 drugs granted approval under the US Food and Drug Administration’s (FDA) accelerated approval pathway.

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Gene Discovery May Lead to Better Alzheimer's Treatments

Drugs.com

THURSDAY, April 11, 2024 -- The discovery of a gene variant that rids the brain of toxic plaques linked to Alzheimer's might lead to new treatments for the disease, researchers report.The variant arises naturally in people who don't seem to get.

Treatment 111
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Breakthrough promises secure quantum computing at home

Science Daily: Pharmacology News

The full power of next-generation quantum computing could soon be harnessed by millions of individuals and companies, thanks to a breakthrough guaranteeing security and privacy. This advance promises to unlock the transformative potential of cloud-based quantum computing.

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Azure SQL Server Performance Check Automation

Perficient: Drug Development

On Operational projects that involves heavy data processing on a daily basis, there’s a need to monitor the DB performance. Over a period of time, the workload grows causing potential issues. While there are best practices to handle the processing by adopting DBA strategies (indexing, partitioning, collecting STATS, reorganizing tables/indexes, purging data, allocating bandwidth separately for ETL/DWH users, Peak time optimization, effective DEV query Re-writes etc.,), it is necessary to be awar

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GSK’s endometrial cancer therapy approved in Scotland

Drug Discovery World

The Scottish Medicines Consortium (SMC) has accepted GSK’s dostarlimab as a treatment for adult patients with endometrial cancer when used in combination with platinum-containing chemotherapy. Specifically, dostarlimab will be used for patients with mismatch repair deficient (dMMR)/microsatellite instability-high (MSI-H) primary advanced or recurrent endometrial cancer and who are candidates for systemic therapy.

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Wegovy Helps Those With Both Diabetes, Heart Failure: Study

Drugs.com

TUESDAY, April 9, 2024 -- For people struggling with both diabetes and a common type of heart failure, the weight-loss drug Wegovy may do more for their health than help them shed pounds, new research suggests.In the study, published Saturday in.

Research 111
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New drug prevents flu-related inflammation and lung damage

Science Daily: Pharmacology News

Findings show a newly created drug can prevent runaway inflammation while still allowing the immune system to handle the virus, even when given late into infection.

Virus 122
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Women want to participate in clinical trials. Lack of flexibility is still a problem.

BioPharma Drive: Drug Pricing

Underrepresentation of women in clinical trials affects the resulting drugs that become available later. Even small changes could boost participation.

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AMR: Steps in the right direction

Drug Discovery World

News that the UK is supporting two new initiatives to help further the development of antimicrobials alongside other solutions to tackle resistant infections is welcome news for a sector that has, in recent years, struggled to attract the funding and attention it deserves. The Pathways to Antimicrobial Clinical Efficacy (PACE) initiative and another project being led by The Infection Innovation Consortium: iiCON will serve as important stepping stones for companies looking towards support fo

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Therapeutic Vaccine Prevents Pancreatic Cancer's Recurrence in 3-Year Trial

Drugs.com

MONDAY, April 8, 2024 -- A pancreatic cancer vaccine has continued to protect a small group of patients from their cancer coming back, three years after receiving the jab, a new study says.Eight patients have not had their pancreatic cancer recur.

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Pregnancy accelerates biological aging in a healthy, young adult population

Science Daily: Pharmacology News

Pregnancy may carry a cost, reports a new study. The research shows that women who reported having been pregnant looked biologically older than women who had never been pregnant, and women who had been pregnant more often looked biologically older than those who reported fewer pregnancies.

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