Sat.Apr 06, 2024 - Fri.Apr 12, 2024

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Will Biopharma Companies Shun Vaccine R&D In A New Pandemic?

Forbes: Drug Truths

Only biopharma could have combated Covid-19; no other industry has the capacity to do so. When the world was in crisis, this industry responded. If need be, it will again, despite the financial consequences.

Vaccine 214
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Parkinson's Disease: New theory on the disease's origins and spread

Science Daily: Pharmacology News

New hypothesis paper builds on a growing scientific consensus that Parkinson's disease route to the brain starts in either the nose or the gut and proposes that environmental toxicants are the likely source.

Disease 145
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Psychiatry drugs finally have pharma’s attention. Can they keep it?

BioPharma Drive: Drug Pricing

Recent biotech company acquisitions have put emerging schizophrenia treatments in focus. But many development hurdles still stand in the way of new medicines for the brain.

Treatment 137
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Chlamydia Vaccine Shows Promise in Early Trial

Drugs.com

FRIDAY, April 12, 2024 -- A chlamydia vaccine has triggered immune responses in an early trial, raising hopes that one day it might help curb the spread of the sexually transmitted infection (STI).There is currently no vaccine for chlamydia, which.

Vaccine 116
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Using Internal Traffic Control Plans to Prevent Construction Worker Injuries and Fatalities in Work Zones

NIOSH Science Blog: Drugs

Struck-by injuries are the leading cause of nonfatal injuries and second most common cause of fatalities among construction workers. From 2011 to 2022, there were 1,462 fatal occupational injuries that occurred at road construction sites.[1] Of these, 68% (n=1,000) were among workers in the construction industry (See figure) followed by workers in transportation and warehousing (11%; n=168) and professional and business services (9%; n=132) industries.

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New postpartum depression drugs are here. Diagnosis, treatment hurdles still stand in the way.

BioPharma Drive: Drug Pricing

The first medicine approved for PPD, Sage’s Zulresso, never gained traction. The company is in the midst of launching its second, but long-standing challenges could slow uptake.

Treatment 128
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Many Cancer Drugs Still Unproven 5 Years After Accelerated Approval

Drugs.com

MONDAY, April 8, 2024 -- New research questions the effectiveness of the U.S. Food and Drug Administration's accelerated drug approval program after finding that many cancer drugs remain unproven five years later.The study, published Sunday in the.

Drugs 116
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#ScienceSaturday: April 6, 2024

KIF1A

#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. KIF1A-Related Research Genetic Alterations in a Large Population of Italian Patients Affected by Neurodevelopmental Disorders We often talk about genetic disorders in the context of mutations that change a protein̵

DNA 111
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After being insulted, writing down your feelings on paper then getting rid of it reduces anger

Science Daily: Pharmacology News

Researchers have discovered a simple, but effective, strategy to help people reduce their feelings of anger. Disposing of a piece of paper containing your written thoughts on the cause of your anger can effectively neutralize it. This process is like a Japanese tradition called hakidashisara, in which people write their negative thoughts on a plate then destroy it.

Science 142
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Vertex to buy kidney disease drugmaker Alpine for $4.9B

BioPharma Drive: Drug Pricing

The deal, which company CEO Reshma Kewalramani described as “just the right fit,” is the largest acquistion in Vertex’s 35-year history.

Disease 125
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Spike in Measles Cases Could Threaten Elimination Status in U.S.: CDC

Drugs.com

FRIDAY, April 12, 2024 -- More than 100 measles cases have already been reported in the United States this year, a significant increase over previous years that threatens the country's attempts to eliminate the illness, federal health officials.

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Three Principles for Writing Effective Analytics Documentation

Perficient: Drug Development

Documentation is a crucial part of your analytics implementation. From your Solution Design Reference document to your internal wiki for all resources, making sure that you can write and edit your documentation is key to ensuring a cohesive and thorough understanding of your implementation. With effective documentation, you can: Prevent knowledge gaps among team members and assist in onboarding efforts.

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Revolutionary molecular device unleashes potential for targeted drug delivery and self-healing materials

Science Daily: Pharmacology News

In a new breakthrough that could revolutionise medical and material engineering, scientists have developed a first-of-its-kind molecular device that controls the release of multiple small molecules using force.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Novartis pauses some trials of cancer drug Kisqali to fix manufacturing

BioPharma Drive: Drug Pricing

The company said the pause is necessary to meet regulatory limits on nitrosamine, but added it will not affect commercial supply nor regulatory review of the drug in early breast cancer.

Trials 117
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Household Radon Can Lead to Lung Cancer -- Has Your Home Been Tested?

Drugs.com

THURSDAY, April 11, 2024 -- Kentucky resident Chasity Harney embraced a thoroughly healthy lifestyle -- eating right, exercising and never touching tobacco.So, her 2018 diagnosis of advanced lung cancer, which came at the age of 40, was a complete.

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Optimising CRIPSR gene editing of hard-to-transfect cells

Drug Target Review

Delivery of ribonucleoprotein (RNP) into cells is an essential factor for successful CRISPR gene editing. However, this is difficult to guarantee using traditional CRISPR gene editing methods, especially in hard-to-transfect cells. The standard CRISPR technique involves gathering a group of cells and then electroporating them, using short high-voltage pulses to overcome the barrier of their cell membranes.

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New drug prevents flu-related inflammation and lung damage

Science Daily: Pharmacology News

Findings show a newly created drug can prevent runaway inflammation while still allowing the immune system to handle the virus, even when given late into infection.

Virus 136
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Women want to participate in clinical trials. Lack of flexibility is still a problem.

BioPharma Drive: Drug Pricing

Underrepresentation of women in clinical trials affects the resulting drugs that become available later. Even small changes could boost participation.

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Gene Discovery May Lead to Better Alzheimer's Treatments

Drugs.com

THURSDAY, April 11, 2024 -- The discovery of a gene variant that rids the brain of toxic plaques linked to Alzheimer's might lead to new treatments for the disease, researchers report.The variant arises naturally in people who don't seem to get.

Treatment 111
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Innovative Financing Models for Repurposing Generic Drugs

Drug Patent Watch

A paper presented at the 2nd International Conference on Systems Medicine, AI, and Drug Repurposing proposes a novel approach to overcoming the financial barriers associated with repurposing generic drugs through… Source

Drugs 105
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Breakthrough promises secure quantum computing at home

Science Daily: Pharmacology News

The full power of next-generation quantum computing could soon be harnessed by millions of individuals and companies, thanks to a breakthrough guaranteeing security and privacy. This advance promises to unlock the transformative potential of cloud-based quantum computing.

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Pfizer, with new study results, seeks to bring RSV shot to adults aged 18-59

BioPharma Drive: Drug Pricing

The company plans to submit the trial data to regulators in a bid to win approval of its vaccine Abrysvo in adults as young as 18 years old.

Vaccine 109
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Wegovy Helps Those With Both Diabetes, Heart Failure: Study

Drugs.com

TUESDAY, April 9, 2024 -- For people struggling with both diabetes and a common type of heart failure, the weight-loss drug Wegovy may do more for their health than help them shed pounds, new research suggests.In the study, published Saturday in.

Research 111
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Azure SQL Server Performance Check Automation

Perficient: Drug Development

On Operational projects that involves heavy data processing on a daily basis, there’s a need to monitor the DB performance. Over a period of time, the workload grows causing potential issues. While there are best practices to handle the processing by adopting DBA strategies (indexing, partitioning, collecting STATS, reorganizing tables/indexes, purging data, allocating bandwidth separately for ETL/DWH users, Peak time optimization, effective DEV query Re-writes etc.,), it is necessary to be awar

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Engineers design soft and flexible 'skeletons' for muscle-powered robots

Science Daily: Pharmacology News

Engineers designed modular, spring-like devices to maximize the work of live muscle fibers so they can be harnessed to power biohybrid robots.

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How Patient Engagement Can Reduce Brand Launch Risks

Drug Channels

Today’s guest post comes from Jessica Lens, Chief Patient Experience Officer at CareMetx. Jessica discusses the challenges of patient nonadherence. She then outlines how manufacturers can build adherence into their patient services program to increase patient engagement. To learn more about enhancing patient engagement and adherence, download CareMetx's new report: Driving Brand Success: Minimize Risk and Capture Missed Value from Patient Engagement and Adherence.

Drugs 98
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Therapeutic Vaccine Prevents Pancreatic Cancer's Recurrence in 3-Year Trial

Drugs.com

MONDAY, April 8, 2024 -- A pancreatic cancer vaccine has continued to protect a small group of patients from their cancer coming back, three years after receiving the jab, a new study says.Eight patients have not had their pancreatic cancer recur.

Vaccine 111
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Optimising CRISPR gene editing of hard-to-transfect cells

Drug Target Review

Delivery of ribonucleoprotein (RNP) into cells is an essential factor for successful CRISPR gene editing. However, this is difficult to guarantee using traditional CRISPR gene editing methods, especially in hard-to-transfect cells. The standard CRISPR technique involves gathering a group of cells and then electroporating them, using short high-voltage pulses to overcome the barrier of their cell membranes.

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Inherited predisposition for higher muscle strength may protect against common morbidities

Science Daily: Pharmacology News

A study showed that a genetic predisposition for higher muscle strength predicts a longer lifespan and a lower risk for developing common diseases. This is a highly comprehensive international study on hereditary muscle strength and its relationship to morbidity. The genome and health data of more than 340,000 Finns was used in the research.

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The Top Pharmacy Benefit Managers of 2023: Market Share and Trends for the Biggest Companies—And What’s Ahead

Drug Channels

Three is still the magic number for pharmacy benefit managers (PBMs). For 2023, nearly 80% of all equivalent prescription claims were processed by three companies: the Caremark business of CVS Health, the Express Scripts business of Cigna, and the Optum Rx business of UnitedHealth Group. Read on for Drug Channels Institute’s (DCI’s) latest market share figures, along with a preview of the industry changes that will shift these shares over the next few years.