Sat.Dec 09, 2023 - Fri.Dec 15, 2023

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The Inflation Reduction Act Is Not Impacting Pharma R&D – Yet

Forbes: Drug Truths

Entitled "Pharmaceutical innovation and the Inflation Reduction Act: What can we learn from the first half of 2023", this policy brief examines whether "the IRA has ha.

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‘No tolerance for failure’: An oral history of the first CRISPR medicine

BioPharma Drive: Drug Pricing

A new sickle cell disease therapy developed by CRISPR Therapeutics and Vertex Pharmaceuticals is now approved in the U.S. and U.K. This is the story of how it came to be.

Therapies 357
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How a drought led to the rise of skateboarding in 1970s California

Science Daily: Pharmacology News

Why did professional skateboarding arise in southern California in the 1970s? Was it a coincidence, or was it a perfect storm of multiple factors? It's fairly well-known that a drought in southern California in the mid-1970s led to a ban on filling backyard swimming pools, and these empty pools became playgrounds for freestyle skateboarders in the greater Los Angeles area.

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Too Few Americans Are Getting Vaccinated for Flu, COVID & RSV, CDC Warns

Drugs.com

FRIDAY, Dec. 15, 2023 -- Low vaccination rates for the flu, RSV and COVID-19 are putting Americans at higher risk for severe illness and hospitalization this winter, a new government alert warned Thursday.There is an “urgent need” to boost.

Vaccine 290
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Recorded Webinar: FAIR (meta)-Data & Assay Annotation

Collaborative Drug

Explore key insights from the Pistoia Alliance's FAIR Data & Assay Annotation webinar. Discover the latest in bioassay data management and standardization.

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What happens in the brain while daydreaming?

Science Daily: Pharmacology News

During quiet waking, brain activity in mice suggests the animals are daydreaming about a recent image. Having daydreams about a recently viewed image predicted how the brain would respond to the image in the future. The findings provide a clue that daydreams may play a role in brain plasticity.

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Using CBD & Other Hemp Products? You're Not Alone, Study Finds

Drugs.com

THURSDAY, Dec. 14, 2023 -- The market for cannabidiol (CBD) and other products derived from the hemp plant is now wide open in the United States, but that could bring danger to consumers, the authors of a new report warn.Many people may not.

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Recorded Webinar: Unlocking Potential Hits with an Advanced Deep Learning Methodology

Collaborative Drug

Discover breakthroughs in drug discovery with our recorded webinar. Susana Tomasio of CDD explores deep learning for similarity search in ChEMBL.

Drugs 263
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ASH23: CAR-T for autoimmune disease, real-world questions and sickle cell’s social media mentions

BioPharma Drive: Drug Pricing

Study results disclosed at the American Society of Hematology meeting Saturday suggested potential for cell therapy in lupus and pointed out drug trial limitations.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Scientists unveil complete cell map of a whole mammalian brain

Science Daily: Pharmacology News

Researchers have created a complete cell atlas of a whole mammalian brain. This atlas serves as a map for the mouse brain, describing the type, location, and molecular information of more than 32 million cells and providing information on connectivity between these cells.

Research 320
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Brain Serotonin Levels May Play Role in Alzheimer's Onset

Drugs.com

MONDAY, Dec. 11, 2023 -- Loss of the “happiness” brain hormone serotonin might play a role in the decline of brain function as a person ages, a new study reports.People with mild cognitive impairment (MCI) had up to 25% lower levels of.

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The Government’s Continued Assault On Drug Pricing Could Hurt The Health Of Americans

Forbes: Drug Truths

These renewed attacks on biopharma continue to erode its reputation, thereby handicapping the industry’s ability to develop new cures and to confront any new pandemic. That will negatively impact us all.

Drugs 217
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Apellis eye drug likely to be rejected in Europe, company says

BioPharma Drive: Drug Pricing

According to Apellis executives, reviewers in Europe are skeptical of the benefits of its geographic atrophy medicine, Syfovre, and appear poised to recommend against approval at a meeting next month.

Drugs 318
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Diverse gut bacteria communities protect against harmful pathogens by nutrient blocking

Science Daily: Pharmacology News

New study demonstrates that diverse communities of resident bacteria can protect the human gut from disease-causing microorganisms. However, this protective effect is lost when only single species of gut bacteria are present. The researchers found that protective communities block the growth of harmful pathogens by consuming nutrients that the pathogen needs.

Disease 317
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Avoiding 'Wine Teeth' at Those Holiday Parties

Drugs.com

MONDAY, Dec. 11, 2023 -- The holidays are all about parties, and parties are all about drinking wine. But if you're a red wine lover, how do you avoid stained teeth?“When you drink red wine, you’re encountering a triple threat to your teeth’s.

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Defining the Cell Surface Cysteinome Using Two-Step Enrichment Proteomics

Covalent Modifiers

Tianyang Yan, Lisa M. Boatner, Liujuan Cui, Peter J. Tontonoz, and Keriann M. Backus JACS Au 2023 DOI: 10.1021/jacsau.3c00707 The plasma membrane proteome is a rich resource of functionally important and therapeutically relevant protein targets. Distinguished by high hydrophobicity, heavy glycosylation, disulfide-rich sequences, and low overall abundance, the cell surface proteome remains undersampled in established proteomic pipelines, including our own cysteine chemoproteomics platforms.

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FTC, in unusual move, leads Sanofi to terminate a drug research deal

BioPharma Drive: Drug Pricing

Just before clearing Pfizer’s buyout of Seagen, the regulator threatened to block Sanofi’s licensing deal with Maze Therapeutics, a challenge the biotech called ‘‘unprecedented.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Twenty-year study confirms California forests are healthier when burned -- or thinned

Science Daily: Pharmacology News

A 20-year experiment in the Sierra Nevada confirms that different forest management techniques -- prescribed burning, restoration thinning or a combination of both -- are effective at reducing the risk of catastrophic wildfire in California. These treatments also improve forest health, making trees more resilient to stressors like drought and bark beetles, and they do not negatively impact plant or wildlife biodiversity within individual tree stands, the research found.

Treatment 308
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Most Americans Lose Sleep Due to 'Digital Distractions.' Experts Offer Tips to Help

Drugs.com

SATURDAY, Dec. 9, 2023 -- It has likely happened to everyone at some point: You are poised to go to sleep, but instead a "digital distraction" keeps you up hours later than you had planned."Bedtime procrastination is a common problem, as people.

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Exendin?4: A potential therapeutic strategy for Alzheimer's disease and Parkinson's disease

Chemical Biology and Drug Design

The figure depicts the neuroprotective role of exendin-4 in Alzheimer's disease and Parkinson's disease. Abstract Neurodegenerative disorders, which affect millions worldwide, are marked by a steady decline of neurons that are selectively susceptible. Due to the complex pathological processes underlying neurodegeneration, at present, there is no viable therapy available for neurodegenerative disorders.

Disease 189
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Humira leads ICER’s latest list of ‘unsupported’ price hikes

BioPharma Drive: Drug Pricing

AbbVie’s blockbuster medicine topped a list of treatments that, combined, elevated U.S. healthcare spending by $1.3 billion in 2022, according to the price watchdog’s latest yearly report.

Treatment 301
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Extremely rare bird captured on film

Science Daily: Pharmacology News

A striking and extremely rare half-female, half-male bird has been spotted by a zoologist.

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Half of Diabetes Patients on Ozempic, Mounjaro Stop Using the Meds

Drugs.com

TUESDAY, Dec. 12, 2023 -- Many Americans battling diabetes are turning to a new class of injected drugs that includes blockbusters like Ozempic (semaglutide) and Mounjaro (tirzepatide).But a new study finds half of patients who use these "second.

Drugs 255
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Profiling nuclear cysteine ligandability and effects on nuclear localization using proximity labeling-coupled chemoproteomics

Covalent Modifiers

Qianni Peng, Eranthie Weerapana Cell Chemical Biology , 2023 DOI: [link] The nucleus controls cell growth and division through coordinated interactions between nuclear proteins and chromatin. Mutations that impair nuclear protein association with chromatin are implicated in numerous diseases. Covalent ligands are a promising strategy to pharmacologically target nuclear proteins, such as transcription factors, which lack ordered small-molecule binding pockets.

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ASH23: Pharma branding, Editas’ high bar and clinical trial diversity

BioPharma Drive: Drug Pricing

Editas had the tall task Monday of convincing ASH attendees its gene therapy for sickle cell disease could improve on Casgevy and Lyfgenia.

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Coevolution helps Santa's reindeer feast after flight

Science Daily: Pharmacology News

A new study suggests that it's not Rudolph's red nose that helps reindeer find food during snowy Arctic winters, but instead a unique adaptation of their eyes to their favorite food. Reindeer may have developed their unique ability to see in the ultraviolet spectrum so they can more easily spot their primary food, the algae-fungus fusion known as lichens -- which absorb UV -- in the winter landscape.

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FDA Seizes 1.5 Million Illegal Vaping Products, Including Elf Bar

Drugs.com

FRIDAY, Dec. 15, 2023 -- Federal agents have seized more than 1.4 million illegal vaping products being smuggled into the United States from China. A three-day operation at Los Angeles International Airport resulted in the seizure of 41 shipments.

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Electrophile Scanning Reveals Reactivity Hotspots for the Design of Covalent Peptide Binders

Covalent Modifiers

Nathalie M. Grob, Clint Remarcik, Simon L. Rössler, Jeffrey Y. K. Wong, John C. K. Wang, Jason Tao, Corey L. Smith, Andrei Loas, Stephen L. Buchwald, Dan L. Eaton, Magdalena Preciado López, and Bradley L. Pentelute ACS Chemical Biology 2023 DOI: 10.1021/acschembio.3c00538 Protein–protein interactions (PPIs) are intriguing targets in drug discovery and development.

Drugs 154
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Pfizer to deepen cost cuts as latest sales forecasts miss expectations

BioPharma Drive: Drug Pricing

The company is now expecting to save $4 billion by the end of 2024, with a majority of the spending cuts coming from drug research and development.