This site uses cookies to improve your experience. To help us insure we adhere to various privacy regulations, please select your country/region of residence. If you do not select a country, we will assume you are from the United States. Select your Cookie Settings or view our Privacy Policy and Terms of Use.
Cookie Settings
Cookies and similar technologies are used on this website for proper function of the website, for tracking performance analytics and for marketing purposes. We and some of our third-party providers may use cookie data for various purposes. Please review the cookie settings below and choose your preference.
Used for the proper function of the website
Used for monitoring website traffic and interactions
Cookie Settings
Cookies and similar technologies are used on this website for proper function of the website, for tracking performance analytics and for marketing purposes. We and some of our third-party providers may use cookie data for various purposes. Please review the cookie settings below and choose your preference.
Strictly Necessary: Used for the proper function of the website
Performance/Analytics: Used for monitoring website traffic and interactions
Modern humans descended from not one, but at least two ancestral populations that drifted apart and later reconnected, long before modern humans spread across the globe.
Antonia C. Darragh, Andrew M. Hanna, Justin H. Lipner, Alastair J. King, Nicole B. Servant, and Mirza Jahic ACS Pharmacol. Transl. Sci. 2025 [link] Uncovering a drugs mechanism of action and possible adverse effects are critical components in drug discovery and development. Moreover, it provides evidence for why some drugs prove more effective than others and how to design better drugs altogether.
By Sara W. Koblitz Integral to the careful balance Congress struck when passing the Hatch-Waxman Amendments, the patent term extension (PTE) is intended to restore patent life that was consumed during regulatory review of an FDA-regulated product. Even though the PTE provisions established in the Drug Price Competition and Patent Restoration Act are forty-plus years old, courts are still grappling with questions about how to best implement the Patent Term Extension.
The review provides a comprehensive analysis of non-hydroxamate inhibitors for IspC, an enzyme crucial in the MEP pathway, highlighting its structural diversity and improved drug development potential. It details the design strategies for lipophilic and bisubstrate non-hydroxamate inhibitors, emphasizing their enhanced metal-ion coordination and increased inhibitory potency against IspC.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
An accordion is a UI element that displays content in a compact, space-saving way. It lets users expand or collapse sections, making it a great choice for FAQ sections, menus, or any content that can be organized into collapsible panels. In this guide, well walk you through how to implement a simple accordion with HTML, CSS, and JavaScript. What is an Accordion?
The pharmaceutical R&D landscape continues to evolve rapidly with advances in computational technologies and artificial intelligence. Our recent Q1 2025 scientific webinar brought together industry veterans Dr. Chris Waller and Dr. Dimitris Agrafiotis to discuss the current state and future directions of drug discovery informatics in large pharmaceutical organizations led by CDD's Founder and CEO, Dr.
Acute Myeloid Leukemia (AML) is one of the most aggressive forms of blood cancer, characterized by the rapid growth of abnormal white blood cells in the bone marrow and blood. It has a high mortality rate, with a five-year survival rate of approximately 30% for adults. Despite advancements in oncology, AML treatment remains challenging due to its genetic complexity, high relapse rates, and resistance to standard therapies.
Signup to get articles personalized to your interests!
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Acute Myeloid Leukemia (AML) is one of the most aggressive forms of blood cancer, characterized by the rapid growth of abnormal white blood cells in the bone marrow and blood. It has a high mortality rate, with a five-year survival rate of approximately 30% for adults. Despite advancements in oncology, AML treatment remains challenging due to its genetic complexity, high relapse rates, and resistance to standard therapies.
Neuropsychiatric treatment is on the verge of a major transformation. Neuropsychiatric disorders, affecting millions worldwide, disrupt the brain’s intricate processes of mood regulation, cognition and behaviour. Historically, treatment options have been limited, with patients relying on daily medications that have minimal efficacy and troublesome side effects.
Introduction to Copilot Agents In today’s fast-paced digital landscape, efficiency and productivity are paramount. Customizing AI to meet your business needs is key to maintaining a competitive edge. Enter Copilot Agents specialized intelligent AI assistants designed to streamline workflows by automating repetitive tasks, providing actionable insights, and seamlessly integrating with your existing tools and data sources.
The Biosimilar Revolution: How It's Changing the Game for Biologic Drug Manufacturers As the pharmaceutical industry continues to evolve, one trend is gaining significant attention: the rise of biosimilars. For those who may be new to this concept, biosimilars are biologic drugs that are highly similar to existing biologic medicines, but at a lower cost.
What is a degron? At the most fundamental level you can think of a degron as a sequence of amino acids or a structural motif that can facilitate the degradation of protein substrates. Researchers are interested in degrons because they provide insight into the way targeted protein degradation takes place naturally in human or other cells or how it can be engineered by new technologies like degron tags.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
What Is BYOD in Clinical Trials? Bring Your Own Device (BYOD) is changing the way clinical trials collect and manage. The post Bring Your Own Device (BYOD) Clinical Trials: How They Transform Decentralized Data Capture appeared first on Crucial Data Solutions.
TypeScript offers powerful type manipulation capabilities that allow developers to create more flexible and maintainable code. Three key features that enable this are keyof, typeof, and Mapped Types. Let’s explore each of them with examples. keyof : Thekeyofoperator takes an object type and produces a string or numeric literal union of its keys.
Unlock the Secrets to a Successful Generic Drug Launch Are you a pharmaceutical executive looking to bring a generic version of a popular medication to market? Or perhaps you're a healthcare professional interested in understanding the intricacies of generic drug launches? Whatever your role, a successful generic drug launch requires careful planning, strategic execution, and a deep understanding of the regulatory landscape.
WEDNESDAY, March 19, 2025 -- People often say they own a gun to protect themselves and their families.But firearms owners rarely use their weapon in self-defense, a new study says.An overwhelming majority of gun owners -- 92% -- say theyve never u.
Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Researchers have developed eye drops that extend vision in animal models of a group of inherited diseases that lead to progressive vision loss in humans, known as retinitis pigmentosa.
Perficient is excited to announce that we have achieved Elite level partner status within the Databricks partner network. This top-tier recognition highlights the outstanding efforts of our talented Databricks strategists, architects, industry leaders, and engineers. Its a testament to our data and AI expertise and unwavering commitment to delivering transformative results for our clients.
The Hidden Costs of Drug Patent Litigation: How to Stay Ahead of the Game As a pharmaceutical professional, you're no stranger to the complexities of drug patent litigation. The stakes are high, and the costs can be astronomical. But what if I told you that there's a way to manage these costs and stay ahead of the game? In today's fast-paced pharmaceutical landscape, patent litigation is an inevitable reality.
MONDAY, March 17, 2025 -- For 21 years, Sebastien Beauzile lived with the chronic pain of sickle cell anemia. Now, thanks to a groundbreaking genetic treatment, he is the first person in New York to be cured of the disease. "Sickle cell was like.
Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
An experimental drug appears to reduce the risk of Alzheimer's-related dementia in people destined to develop the disease in their 30s, 40s or 50s, according to the results of a new study. The findings suggest -- for the first time in a clinical trial -- that early treatment to remove amyloid plaques from the brain many years before symptoms arise can delay the onset of Alzheimer's dementia.
Continuing Our Plop.js Journey from last blog In our previous discussion, we explored an introduction to Plop.js and its installation in a Next.js project. Additionally, we looked at a basic skeleton of plopfile.js. Understanding the Components of plopfile.js As we saw earlier, the plopfile.js consists of key elements that define the generator. Lets break them down again for clarity: The setGenerator creates a generator of the plop.
Unlocking Strategic Investment Opportunities in the Pharmaceutical Industry As we navigate the ever-evolving landscape of the pharmaceutical industry, one thing remains constant: the expiration of patents on blockbuster medications. These expirations can have a significant impact on the market, creating opportunities for strategic investment and growth.
WEDNESDAY, March 19, 2025 -- A controversial proposal from U.S Secretary of Health and Human Services Robert F. Kennedy Jr. to let bird flu naturally spread through poultry farms is raising alarms among scientists -- who say the move could be.
Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Ed Kaye, Stoke’s longtime leader, will be replaced by former Vertex executive Ian Smith. Elsewhere, all 12 drugmakers targeted for second round of Medicare price talks agreed to participate.
We all may have come across this situation countless times in our projectscopying and pasting files just to create a new component, page, or service. Unfortunately, this slows us down and hampers our productivity by introducing errors into the workflow. However, there’s a solution! Plop.js is the answer to this problem, as it automates these tasks and allows us to focus on writing great code.
Navigating the Complex World of Biosimilar Regulatory Agency Interactions As a biosimilar developer, you know that getting your product to market can be a long and arduous process. One of the most critical components of this journey is interacting with regulatory agencies. But how can you ensure that these interactions are effective and set your product up for success?
FRIDAY, March 21, 2025 -- There are a ton of suggestions out there for soothing an aching lower back -- acupuncture, heat, cannabinoids, muscle relaxants, TENS electrical pulses, dry cupping, opioids, massage and more.But not much actually eases.
Study results showed Orca’s treatment, a purified mix of donor-derived T cells and stem cells, was safer than standard transplant in treating certain blood cancers.
The Dark Energy Spectroscopic Instrument used millions of galaxies and quasars to build the largest 3D map of our universe to date. Combining their data with other experiments shows signs that the impact of dark energy may be weakening over time -- and the standard model of how the universe works may need an update.
Navigating the Complex World of Drug Patents: A Comprehensive Strategy is Key As a pharmaceutical professional, you know that developing new medications is a costly and time-consuming process. But what happens when your product's patent is about to expire, or you're facing competition from generic manufacturers? A well-crafted drug patent strategy can make all the difference in protecting your intellectual property and maintaining market share.
SATURDAY, March 15, 2025 -- Scientists have created a handheld sensor that can quickly detect bird flu (H5N1) in the air, potentially stopping outbreaks before they spread.Research published recently in the journal ACS Sensors noted the sensor is.
We organize all of the trending information in your field so you don't have to. Join 15,000+ users and stay up to date on the latest articles your peers are reading.
You know about us, now we want to get to know you!
Let's personalize your content
Let's get even more personalized
We recognize your account from another site in our network, please click 'Send Email' below to continue with verifying your account and setting a password.
Let's personalize your content