Sat.Mar 15, 2025 - Fri.Mar 21, 2025

article thumbnail

Genetic study reveals hidden chapter in human evolution

Science Daily: Pharmacology News

Modern humans descended from not one, but at least two ancestral populations that drifted apart and later reconnected, long before modern humans spread across the globe.

283
283
article thumbnail

Comprehensive Characterization of Bruton’s Tyrosine KinaseInhibitor Specificity, Potency, and Biological Effects: Insights into Covalent and Noncovalent Mechanistic Signatures

Covalent Modifiers

Antonia C. Darragh, Andrew M. Hanna, Justin H. Lipner, Alastair J. King, Nicole B. Servant, and Mirza Jahic ACS Pharmacol. Transl. Sci. 2025 [link] Uncovering a drugs mechanism of action and possible adverse effects are critical components in drug discovery and development. Moreover, it provides evidence for why some drugs prove more effective than others and how to design better drugs altogether.

FDA 100
Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

article thumbnail

The Issue with Reissue: PTE Edition

FDA Law Blog: Biosimilars

By Sara W. Koblitz Integral to the careful balance Congress struck when passing the Hatch-Waxman Amendments, the patent term extension (PTE) is intended to restore patent life that was consumed during regulatory review of an FDA-regulated product. Even though the PTE provisions established in the Drug Price Competition and Patent Restoration Act are forty-plus years old, courts are still grappling with questions about how to best implement the Patent Term Extension.

article thumbnail

Non‐Hydroxamate Inhibitors of IspC Enzyme in the MEP Pathway: Structural Insights and Drug Development Potential

Chemical Biology and Drug Design

The review provides a comprehensive analysis of non-hydroxamate inhibitors for IspC, an enzyme crucial in the MEP pathway, highlighting its structural diversity and improved drug development potential. It details the design strategies for lipophilic and bisubstrate non-hydroxamate inhibitors, emphasizing their enhanced metal-ion coordination and increased inhibitory potency against IspC.

article thumbnail

Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

article thumbnail

Implementing an Accordion with JavaScript: A Simple Guide

Perficient: Drug Development

An accordion is a UI element that displays content in a compact, space-saving way. It lets users expand or collapse sections, making it a great choice for FAQ sections, menus, or any content that can be organized into collapsible panels. In this guide, well walk you through how to implement a simple accordion with HTML, CSS, and JavaScript. What is an Accordion?

52
article thumbnail

Drug Discovery Informatics for Big Pharma: Key Webinar Insights

Collaborative Drug

The pharmaceutical R&D landscape continues to evolve rapidly with advances in computational technologies and artificial intelligence. Our recent Q1 2025 scientific webinar brought together industry veterans Dr. Chris Waller and Dr. Dimitris Agrafiotis to discuss the current state and future directions of drug discovery informatics in large pharmaceutical organizations led by CDD's Founder and CEO, Dr.

Drugs 256

More Trending

article thumbnail

The future of mental health treatment: Zelquistinel’s role

Drug Target Review

Neuropsychiatric treatment is on the verge of a major transformation. Neuropsychiatric disorders, affecting millions worldwide, disrupt the brain’s intricate processes of mood regulation, cognition and behaviour. Historically, treatment options have been limited, with patients relying on daily medications that have minimal efficacy and troublesome side effects.

article thumbnail

Enhancing Business Efficiency with AI: An Introduction to Copilot Agents

Perficient: Drug Development

Introduction to Copilot Agents In today’s fast-paced digital landscape, efficiency and productivity are paramount. Customizing AI to meet your business needs is key to maintaining a competitive edge. Enter Copilot Agents specialized intelligent AI assistants designed to streamline workflows by automating repetitive tasks, providing actionable insights, and seamlessly integrating with your existing tools and data sources.

article thumbnail

The impact of biosimilars on biologic drug life cycle management

Drug Patent Watch

The Biosimilar Revolution: How It's Changing the Game for Biologic Drug Manufacturers As the pharmaceutical industry continues to evolve, one trend is gaining significant attention: the rise of biosimilars. For those who may be new to this concept, biosimilars are biologic drugs that are highly similar to existing biologic medicines, but at a lower cost.

article thumbnail

The Roles of Degrons in Targeted Protein Degradation | BMG LABTECH

BMG Labtech

What is a degron? At the most fundamental level you can think of a degron as a sequence of amino acids or a structural motif that can facilitate the degradation of protein substrates. Researchers are interested in degrons because they provide insight into the way targeted protein degradation takes place naturally in human or other cells or how it can be engineered by new technologies like degron tags.

article thumbnail

From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

article thumbnail

Bring Your Own Device (BYOD) Clinical Trials: How They Transform Decentralized Data Capture

Crucial Data Solutions

What Is BYOD in Clinical Trials? Bring Your Own Device (BYOD) is changing the way clinical trials collect and manage. The post Bring Your Own Device (BYOD) Clinical Trials: How They Transform Decentralized Data Capture appeared first on Crucial Data Solutions.

article thumbnail

TypeScript Type Manipulation with keyof, typeof, and Mapped Types

Perficient: Drug Development

TypeScript offers powerful type manipulation capabilities that allow developers to create more flexible and maintainable code. Three key features that enable this are keyof, typeof, and Mapped Types. Let’s explore each of them with examples. keyof : Thekeyofoperator takes an object type and produces a string or numeric literal union of its keys.

52
article thumbnail

How to Implement a Successful Generic Drug Launch Strategy

Drug Patent Watch

Unlock the Secrets to a Successful Generic Drug Launch Are you a pharmaceutical executive looking to bring a generic version of a popular medication to market? Or perhaps you're a healthcare professional interested in understanding the intricacies of generic drug launches? Whatever your role, a successful generic drug launch requires careful planning, strategic execution, and a deep understanding of the regulatory landscape.

article thumbnail

Firearms Rarely Used For Protection Against Crime

Drugs.com

WEDNESDAY, March 19, 2025 -- People often say they own a gun to protect themselves and their families.But firearms owners rarely use their weapon in self-defense, a new study says.An overwhelming majority of gun owners -- 92% -- say theyve never u.

289
289
article thumbnail

How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

article thumbnail

New eye drops slow vision loss in animals

Science Daily: Pharmacology News

Researchers have developed eye drops that extend vision in animal models of a group of inherited diseases that lead to progressive vision loss in humans, known as retinitis pigmentosa.

Disease 276
article thumbnail

Perficient Achieves Databricks Elite Partner Status

Perficient: Drug Development

Perficient is excited to announce that we have achieved Elite level partner status within the Databricks partner network. This top-tier recognition highlights the outstanding efforts of our talented Databricks strategists, architects, industry leaders, and engineers. Its a testament to our data and AI expertise and unwavering commitment to delivering transformative results for our clients.

article thumbnail

Managing Drug Patent Litigation Costs

Drug Patent Watch

The Hidden Costs of Drug Patent Litigation: How to Stay Ahead of the Game As a pharmaceutical professional, you're no stranger to the complexities of drug patent litigation. The stakes are high, and the costs can be astronomical. But what if I told you that there's a way to manage these costs and stay ahead of the game? In today's fast-paced pharmaceutical landscape, patent litigation is an inevitable reality.

Drugs 92
article thumbnail

First Patient Cured of Sickle Cell Anemia

Drugs.com

MONDAY, March 17, 2025 -- For 21 years, Sebastien Beauzile lived with the chronic pain of sickle cell anemia. Now, thanks to a groundbreaking genetic treatment, he is the first person in New York to be cured of the disease. "Sickle cell was like.

Treatment 290
article thumbnail

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

article thumbnail

Anti-amyloid drug shows signs of preventing Alzheimer's dementia

Science Daily: Pharmacology News

An experimental drug appears to reduce the risk of Alzheimer's-related dementia in people destined to develop the disease in their 30s, 40s or 50s, according to the results of a new study. The findings suggest -- for the first time in a clinical trial -- that early treatment to remove amyloid plaques from the brain many years before symptoms arise can delay the onset of Alzheimer's dementia.

article thumbnail

Plop.js – A micro-generator framework: Template Creation (Part-2)

Perficient: Drug Development

Continuing Our Plop.js Journey from last blog In our previous discussion, we explored an introduction to Plop.js and its installation in a Next.js project. Additionally, we looked at a basic skeleton of plopfile.js. Understanding the Components of plopfile.js As we saw earlier, the plopfile.js consists of key elements that define the generator. Lets break them down again for clarity: The setGenerator creates a generator of the plop.

article thumbnail

Drug Patent Expirations: Unlocking Strategic Investment Opportunities

Drug Patent Watch

Unlocking Strategic Investment Opportunities in the Pharmaceutical Industry As we navigate the ever-evolving landscape of the pharmaceutical industry, one thing remains constant: the expiration of patents on blockbuster medications. These expirations can have a significant impact on the market, creating opportunities for strategic investment and growth.

article thumbnail

RFK Jr. Suggests Letting Bird Flu Spread

Drugs.com

WEDNESDAY, March 19, 2025 -- A controversial proposal from U.S Secretary of Health and Human Services Robert F. Kennedy Jr. to let bird flu naturally spread through poultry farms is raising alarms among scientists -- who say the move could be.

279
279
article thumbnail

Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

article thumbnail

Stoke CEO exits; Medicare drug price talks advance

BioPharma Drive: Drug Pricing

Ed Kaye, Stoke’s longtime leader, will be replaced by former Vertex executive Ian Smith. Elsewhere, all 12 drugmakers targeted for second round of Medicare price talks agreed to participate.

Drugs 264
article thumbnail

Plop.js – A micro-generator framework: Introduction and Installation (Part-1)

Perficient: Drug Development

We all may have come across this situation countless times in our projectscopying and pasting files just to create a new component, page, or service. Unfortunately, this slows us down and hampers our productivity by introducing errors into the workflow. However, there’s a solution! Plop.js is the answer to this problem, as it automates these tasks and allows us to focus on writing great code.

article thumbnail

Strategies for effective biosimilar regulatory agency interactions

Drug Patent Watch

Navigating the Complex World of Biosimilar Regulatory Agency Interactions As a biosimilar developer, you know that getting your product to market can be a long and arduous process. One of the most critical components of this journey is interacting with regulatory agencies. But how can you ensure that these interactions are effective and set your product up for success?

article thumbnail

Not Much Works To Soothe Low Back Pain, Study Says

Drugs.com

FRIDAY, March 21, 2025 -- There are a ton of suggestions out there for soothing an aching lower back -- acupuncture, heat, cannabinoids, muscle relaxants, TENS electrical pulses, dry cupping, opioids, massage and more.But not much actually eases.

263
263
article thumbnail

Orca Bio to seek approval of T cell transplant after positive trial data

BioPharma Drive: Drug Pricing

Study results showed Orca’s treatment, a purified mix of donor-derived T cells and stem cells, was safer than standard transplant in treating certain blood cancers.

Trials 261
article thumbnail

New DESI results strengthen hints that dark energy may evolve

Science Daily: Pharmacology News

The Dark Energy Spectroscopic Instrument used millions of galaxies and quasars to build the largest 3D map of our universe to date. Combining their data with other experiments shows signs that the impact of dark energy may be weakening over time -- and the standard model of how the universe works may need an update.

252
252
article thumbnail

Developing a Comprehensive Drug Patent Strategy

Drug Patent Watch

Navigating the Complex World of Drug Patents: A Comprehensive Strategy is Key As a pharmaceutical professional, you know that developing new medications is a costly and time-consuming process. But what happens when your product's patent is about to expire, or you're facing competition from generic manufacturers? A well-crafted drug patent strategy can make all the difference in protecting your intellectual property and maintaining market share.

Drugs 40
article thumbnail

Scientists Develop Rapid Bird Flu Detector for Airborne Test

Drugs.com

SATURDAY, March 15, 2025 -- Scientists have created a handheld sensor that can quickly detect bird flu (H5N1) in the air, potentially stopping outbreaks before they spread.Research published recently in the journal ACS Sensors noted the sensor is.

264
264
article thumbnail

CDD Vault Update (March #2 2025):  Macromolecule Atomistic Rendering, AI Datasets, Import Inventory Locations, Larger Inventory Boxes, Dark Mode

Collaborative Drug

CDD Update March #2 2025 Full Atom Layout of Macromolecules New Dataset for AI Similarity Searching Import Inventory Locations by Unique Box Names:

250
250
article thumbnail

NGS is changing GxP compliance. Will you adapt?

BioPharma Drive: Drug Pricing

Discover NGS for GxP compliance with full audit trails, operational control and robust data security.