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A spatial approach to understanding drug dynamics using mass spectrometry imaging

Drug Target Review

By integrating MSI with histopathology, clinical chemistry and DMPK data, researchers can develop mechanistic hypotheses of toxicity, improving decision making and reducing unnecessary follow-up studies. For good laboratory practice (GLP) studies, project teams may consider freezing select tissue blocks for MSI under a non-GLP protocol.

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Women in Stem with Dr Emily Leproust

Drug Target Review

I started my journey in chemistry – first as an undergraduate and then in my PhD programme at the University of Houston, where I focused on organic chemistry and nucleic acids chemistry. Researchers were able to use our synthetic RNA controls as a reference to verify and validate assays.

DNA 116
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Making the Centrifuge

Codon

Many discoveries — from microscopy to organic chemistry — came from German scientists working in a period of increasing industrialization, economic growth, and military mobility. Left: The laboratory, built within a castle kitchen in Tübingen, where Miescher discovered DNA.

DNA 57
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A Brief History of GFP

Codon

Credit: Photo by Claudia Mills, Friday Harbor Laboratory from Tsien’s Nobel Lecture. First, Hirata was so impressed with his young student that he granted him a PhD in organic chemistry in 1960. University of Washington, Friday Harbor Laboratories, 1961. The jellyfish Aequorea victoria. More good news soon followed.

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