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By integrating MSI with histopathology, clinical chemistry and DMPK data, researchers can develop mechanistic hypotheses of toxicity, improving decision making and reducing unnecessary follow-up studies. For good laboratory practice (GLP) studies, project teams may consider freezing select tissue blocks for MSI under a non-GLP protocol.
I started my journey in chemistry – first as an undergraduate and then in my PhD programme at the University of Houston, where I focused on organicchemistry and nucleic acids chemistry. Researchers were able to use our synthetic RNA controls as a reference to verify and validate assays.
Many discoveries — from microscopy to organicchemistry — came from German scientists working in a period of increasing industrialization, economic growth, and military mobility. Left: The laboratory, built within a castle kitchen in Tübingen, where Miescher discovered DNA.
Credit: Photo by Claudia Mills, Friday Harbor Laboratory from Tsien’s Nobel Lecture. First, Hirata was so impressed with his young student that he granted him a PhD in organicchemistry in 1960. University of Washington, Friday Harbor Laboratories, 1961. The jellyfish Aequorea victoria. More good news soon followed.
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