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CAR-NK cells: promising for cancer therapy

Drug Target Review

They recognise ‘cell stress molecules’ on the surface of infected, old, injured and cancerous cells without the need for complex pre-stimulation signals of the adaptive immune system (eg, T cells). NK cells can be readily extracted from umbilical cord blood or peripheral blood of adult donors.

Therapies 118
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Time for change: non-human primates in drug research

Drug Target Review

European Directive 2010/63/EU on the protection of animals used for scientific purposes. Throughout her experience in academic research, she gained distinct knowledge and expertise in both disease modelling and biobank building and in the differentiation of iPSCs into cardiac and neuronal cell types. USDA (2020).

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Advanced 3D cell-based technologies

Drug Target Review

The chips can be modelled with primary cells, IPS derived stem cells or patient derived cells and potentiates to unlock molecular mechanisms that drive the disease pathophysiology, holding a greater promise. From 3D cell culture to organs-on-chips. Trends in Cell Biology. 2011;21(12):745-54.

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2025 Merkin Prize in Biomedical Technology awarded to pioneers of CAR T-cell therapy

Broad Institute

The $400,000 prize, to be shared among the four winners, recognizes their role in creating and advancing a technology that has reshaped how physicians treat leukemia, lymphoma, and multiple myeloma, and is now showing promise in treating autoimmune and infectious diseases. A single dose of the engineered cells wiped out signs of disease.

Therapies 119
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TACACICLIB, AUR-102, AURIGENE

New Drug Approvals

The present invention is directed to methods of preparation of compound of formula (I) that is useful for inhibiting Cyclin-dependent kinase 7 (CDK7) and for treating diseases or disorders mediated thereby. Recent genetic and biochemical studies have confirmed the importance of CDK7 for cell cycle progression (Larochelle.

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Discovering an Antimalarial Drug in Mao’s China

Codon

“Cumulatively the deadliest of the human infectious diseases,” malaria has been documented throughout recorded history. In this light, scouring old Chinese remedies for new treatments for a disease specifically troublesome during war was entirely intuitive for Chinese biomedical scientists like Tu Youyou in the mid-20th century.

Drugs 141
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The Codon Guide to Synthetic Biology

Codon

Nature Reviews Genetics (2010). Link Is the cell really a machine? , Journal of Theoretical Biology (2019). Link The second wave of synthetic biology: from modules to systems , by Purnick P.E.M. & Nature Reviews Molecular Cell Biology (2009). Nature Reviews Molecular Cell Biology (2014).

DNA 98